PHP_DROME - dbPTM
PHP_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PHP_DROME
UniProt AC P39769
Protein Name Polyhomeotic-proximal chromatin protein
Gene Name ph-p
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 1589
Subcellular Localization Nucleus.
Protein Description Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. Component of the PcG multiprotein PRC1 complex, a complex that acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-118', rendering chromatin heritably changed in its expressibility. Plays a role in regulating the expression of other pair-rule genes such as eve, ftz, and H..
Protein Sequence MDRRALKFMQKRADTESDTTTPVSTTASQGISASAILAGGTLPLKDNSNIREKPLHHNYNHNNNNSSQHSHSHQQQQQQQVGGKQLERPLKCLETLAQKAGITFDEKYDVASPPHPGIAQQQATSGTGPATGSGSVTPTSHRHGTPPTGRRQTHTPSTPNRPSAPSTPNTNCNSIARHTSLTLEKAQNPGQQVAATTTVPLQISPEQLQQFYASNPYAIQVKQEFPTHTTSGSGTELKHATNIMEVQQQLQLQQQLSEANGGGAASAGAGGAASPANSQQSQQQQHSTAISTMSPMQLAAATGGVGGDWTQGRTVQLMQPSTSFLYPQMIVSGNLLHPGGLGQQPIQVITAGKPFQGNGPQMLTTTTQNAKQMIGGQAGFAGGNYATCIPTNHNQSPQTVLFSPMNVISPQQQQNLLQSMAAAAQQQQLTQQQQQFNQQQQQQLTQQQQQLTAALAKVGVDAQGKLAQKVVQKVTTTSSAVQAATGPGSTGSTQTQQVQQVQQQQQQTTQTTQQCVQVSQSTLPVGVGGQSVQTAQLLNAGQAQQMQIPWFLQNAAGLQPFGPNQIILRNQPDGTQGMFIQQQPATQTLQTQQNQIIQCNVTQTPTKARTQLDALAPKQQQQQQQVGTTNQTQQQQLAVATAQLQQQQQQLTAAALQRPGAPVMPHNGTQVRPASSVSTQTAQNQSLLKAKMRNKQQPVRPALATLKTEIGQVAGQNKVVGHLTTVQQQQQATNLQQVVNAAGNKMVVMSTTGTPITLQNGQTLHAATAAGVDKQQQQLQLFQKQQILQQQQMLQQQIAAIQMQQQQAAVQAQQQQQQQVSQQQQVNAQQQQAVAQQQQAVAQAQQQQREQQQQVAQAQAQHQQALANATQQILQVAPNQFITSHQQQQQQQLHNQLIQQQLQQQAQAQVQAQVQAQAQQQQQQREQQQNIIQQIVVQQSGATSQQTSQQQQHHQSGQLQLSSVPFSVSSSTTPAGIATSSALQAALSASGAIFQTAKPGTCSSSSPTSSVVTITNQSSTPLVTSSTVASIQQAQTQSAQVHQHQQLISATIAGGTQQQPQGPPSLTPTTNPILAMTSMMNATVGHLSTAPPVTVSVTSTAVTSSPGQLVLLSTASSGGGGSIPATPTKETPSKGPTATLVPIGSPKTPVSGKDTCTTPKSSTPATVSASVEASSSTGEALSNGDASDRSSTPSKGATTPTSKQSNAAVQPPSSTTPNSVSGKEEPKLATCGSLTSATSTSTTTTITNGIGVARTTASTAVSTASTTTTSSGTFITSCTSTTTTTTSSISNGSKDLPKAMIKPNVLTHVIDGFIIQEANEPFPVTRQRYADKDVSDEPPKKKATMQEDIKLSGIASAPGSDMVACEQCGKMEHKAKLKRKRYCSPGCSRQAKNGIGGVGSGETNGLGTGGIVGVDAMALVDRLDEAMAEEKMQTEATPKLSESFPILGASTEVPPMSLPVQAAISAPSPLAMPLGSPLSVALPTLAPLSVVTSGAAPKSSEVNGTDRPPISSWSVDDVSNFIRELPGCQDYVDDFIQQEIDGQALLLLKEKHLVNAMGMKLGPALKIVAKVESIKEVPPPGEAKDPGAQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
133PhosphorylationGTGPATGSGSVTPTS
CCCCCCCCCCCCCCC		24.4421082442
145PhosphorylationPTSHRHGTPPTGRRQ
CCCCCCCCCCCCCCC		21.7021082442
180PhosphorylationNSIARHTSLTLEKAQ
HHHHHHHCEEHHHCC		17.1521082442
1145PhosphorylationATLVPIGSPKTPVSG
EEEEECCCCCCCCCC		24.7619429919
1148PhosphorylationVPIGSPKTPVSGKDT
EECCCCCCCCCCCCC		32.1022817900
1202PhosphorylationKGATTPTSKQSNAAV
CCCCCCCCCCCCCCC		29.8727626673
1223AcetylationTPNSVSGKEEPKLAT
CCCCCCCCCCCCCCE		51.9321791702
1457O-linked_GlycosylationSTEVPPMSLPVQAAI
CCCCCCCCCCCCCEE		34.9832510947
1465O-linked_GlycosylationLPVQAAISAPSPLAM
CCCCCEECCCCCCCC		29.4232510947
1511O-linked_GlycosylationGTDRPPISSWSVDDV
CCCCCCCCCCCHHHH		31.3732510947
1570AcetylationPALKIVAKVESIKEV
HHHHHEEEEECCCCC		35.3221791702
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PHP_DROME !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PHP_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PHP_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SIR4_DROMESirt4physical
14605208
PELI_DROMEPliphysical
14605208
RLA1_DROMERpLP1genetic
11732091
DECA_DROMEdppgenetic
27510973
SALM_DROMEsalmgenetic
7955568
SPITZ_DROMEspigenetic
11370860
MCM4_DROMEdpagenetic
11370860
FOJO_DROMEfjgenetic
11370860
BRM_DROMEbrmgenetic
27510973
E75BB_DROMEEip75Bgenetic
11370860
E75BC_DROMEEip75Bgenetic
11370860
E75BA_DROMEEip75Bgenetic
11370860
RUVB2_DROMEreptgenetic
16816423
PC_DROMEPcgenetic
8101825
CORTO_DROMEcortogenetic
9463384
TRX_DROMEtrxgenetic
11370860
TRX_DROMEtrxgenetic
11732091
UBCD1_DROMEeffgenetic
8101825
UBCD1_DROMEeffgenetic
11732091
HSP7D_DROMEHsc70-4genetic
11274417
HSP7D_DROMEHsc70-4genetic
14550797
LOLAL_DROMElolalgenetic
11370860
LOLAL_DROMElolalgenetic
12556479
DOM_DROMEdomgenetic
11262242
PHP_DROMEph-pphysical
9566890
ZEST_DROMEzphysical
11493925
TAF9_DROMEe(y)1physical
11493925
ESC_DROMEescphysical
11581156
SMBT_DROMESfmbtphysical
27151979
TOP2_DROMETop2physical
11172718
PSC_DROMEPscphysical
11493925
PSC_DROMEPscphysical
27151979
PSC_DROMEPscphysical
10412979
PSC_DROMEPscphysical
11493924
PSC_DROMEPscphysical
11583617
PSC_DROMEPscphysical
15280237
PSC_DROMEPscphysical
18923078
PSC_DROMEPscphysical
25415640
PSC_DROMEPscphysical
25468754
PSC_DROMEPscphysical
9372908
PSC_DROMEPscphysical
9566890
TAF4_DROMETaf4physical
11493925
RUVB2_DROMEreptphysical
11493925
TAF6_DROMETaf6physical
11493925
PC_DROMEPcphysical
11493925
PC_DROMEPcphysical
27151979
PC_DROMEPcphysical
10412979
PC_DROMEPcphysical
11493924
PC_DROMEPcphysical
11581156
PC_DROMEPcphysical
11583617
PC_DROMEPcphysical
1353445
PC_DROMEPcphysical
15280237
PC_DROMEPcphysical
18923078
PC_DROMEPcphysical
25415640
PC_DROMEPcphysical
25468754
PC_DROMEPcphysical
9372908
TAF1_DROMETaf1physical
11493925
SCM_DROMEScmphysical
10412979
SCM_DROMEScmphysical
15280237
SCM_DROMEScmphysical
15905166
SCM_DROMEScmphysical
27151979
HSP7D_DROMEHsc70-4physical
11493925
RING1_DROMEScephysical
11493925
RING1_DROMEScephysical
27151979
RING1_DROMEScephysical
11583617
RING1_DROMEScephysical
15280237
RING1_DROMEScephysical
18923078
RING1_DROMEScephysical
25415640
RING1_DROMEScephysical
25468754
TAF5_DROMETaf5physical
11493925
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PHP_DROME

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1145 AND THR-1148, ANDMASS SPECTROMETRY.

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