dbPTM

NPL4_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NPL4_DROME
UniProt AC	Q9VBP9
Protein Name	Nuclear protein localization protein 4 homolog
Gene Name	Npl4
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	652
Subcellular Localization
Protein Description	May be part of a complex that binds ubiquitinated proteins and that is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome..
Protein Sequence	MACAPLLLEQFIYKKRNFAYAFVRHRLFVLCKQSLIRVQSAEGIKRIEISPKSNLKHLYDSVQNALKVDGFGLFKERNFLTELQASGSQLVGTSLRHGDMVYLKQMAGTSSRRTSTTVLDSQAFKTSTISNPNSARPSFNVIEDDVDQALSKADGTIKRERDSKLCHHNANGRCVHCSALEPYDESYLKEHNIKHLSFHSYIRKQTSGMDQGKYFVFDDINCRIKPGCREHPPWPKGICSKCQPSAITLNRQTYRHVDNVMFENTKIVERFLNYWRTTGHQRMGYLYGTYEQHTDVPLGIRAKVAAIYEPPQESTRDSINIQPDEFADDVDAVASALGLKKIGWIFTDLITDDASIGTVKQIRGIESHFITAQECITAGELQNRHPNPCKYASNGVFGSKFVTICVTGDKTKQVHMEGYAVSAQCMALVRDNCLIPTKDAPELGYVRESTDKQYVPDVFYKEKDLYGNEVQRLARPLPVEYLLVDVPASTPLQPIYTFTEYDKRQPFPIENRYIDGHLQDFNALSCYLSAWGEEEFLEAISDFHLLVYLYKMDMLPLRQHMGPLLEAVRTKNPNQAAQFKVVDVWKLLESLIQASSGGSGGTTSYPSGGASASAGASGSEAMDLDANTWTCNHCTFINRGELTSCEICSLPR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
111	Phosphorylation	KQMAGTSSRRTSTTV EECCCCCCCCCCCEE	26.14	22817900
114	Phosphorylation	AGTSSRRTSTTVLDS CCCCCCCCCCEEECC	29.34	19429919
115	Phosphorylation	GTSSRRTSTTVLDSQ CCCCCCCCCEEECCC	21.92	19429919
116	Phosphorylation	TSSRRTSTTVLDSQA CCCCCCCCEEECCCC	21.95	19429919
117	Phosphorylation	SSRRTSTTVLDSQAF CCCCCCCEEECCCCC	20.88	28490779
124	Ubiquitination	TVLDSQAFKTSTISN EEECCCCCCCCCCCC	7.41	31113955
130	Phosphorylation	AFKTSTISNPNSARP CCCCCCCCCCCCCCC	46.45	27794539
134	Phosphorylation	STISNPNSARPSFNV CCCCCCCCCCCCEEE	27.23	21082442
138	Phosphorylation	NPNSARPSFNVIEDD CCCCCCCCEEEECCC	24.73	22817900
152	Ubiquitination	DVDQALSKADGTIKR CHHHHHHHCCCCEEE	51.88	31113955

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NPL4_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NPL4_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NPL4_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
UFD1_DROME	Ufd1-like	physical	14605208
TERA_DROME	TER94	physical	23747190

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NPL4_DROME

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-114; SER-115 ANDTHR-117, AND MASS SPECTROMETRY.	18327897 [Abstract]
"An integrated chemical, mass spectrometric and computational strategyfor (quantitative) phosphoproteomics: application to Drosophilamelanogaster Kc167 cells."; Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D.,Juenger M.A., Eng J.K., Aebersold R., Tao W.A.; Mol. Biosyst. 3:275-286(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-115 AND SER-138, ANDMASS SPECTROMETRY.	17372656 [Abstract]