dbPTM

SMG1_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SMG1_DROME
UniProt AC	Q70PP2
Protein Name	Serine/threonine-protein kinase Smg1
Gene Name	nonC
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	3218
Subcellular Localization	Cytoplasm.
Protein Description	Serine/threonine protein kinase involved in mRNA surveillance. Recognizes the substrate consensus sequence [ST]-Q. Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons, probably by phosphorylating Upf1..
Protein Sequence	MKNAIHPENCNGAGTEEEASSAFHAEIDRVLLNNNGNHGDSSNEGGGGNGSGRGGATGSGNIAGLGGSESMWSPGGGKSHDVAQAFANALLLRNMNHVVGKGQPVVQNHRKAYQCKGDTINPMANGEDLRLSKIIRRLINENNPTVSLELCSKLDQAVRTPINMGYMTCSFVWILDNMLTLYKQCPPPVLEECSKTLGLIGFINRKSYPIYEEFIVKNYKSSKRMQKYMIMALRATLSCDTKCELHMYADKIMLLLKDFLENAESADIFIVVSNTLVQFAASYAETFECHFTDVVDIVIGWQLEAGQPTDLKTHCAQVLEQLTPFFSKQIDFSYGLLDQFVEDITTLEEGEPANTAERVGAFVGAFNTLLKCLARMQIFVGMPTCECIVKMAVDHLIKIMPTLHLNTEALVNINELICICLLNNFTGLDPILLEQVLLDQVKRMISLTELQRQSVLYLLLCTVRRLRARLTPSLVHFIFQSNPYMTKVRLRSPGETSYKLLLRTCQETLLIRNVPLLQQAYKYLVDDIDACLEKLLITAPRSKARKASVLLVFHLSALAALAKQTSSIIGMYACKPSILELLLTNCRAHELKFWSKYPAAQQAIFGLLVVHCQANHNFRTNSSLLRDQELSAENTSPTANSFASILRFLDSVLGQAHQLAPQNLRVLLQWIQMLLRECREKIDLLMEQENFRGICRNIAATASKLVPLESAACIQTVLDYGLERLEKYPKLLILYRDTALQQLQMLSTNYHAPYFQIYAQLPLHLTLTGGESSMPGMASRRVSVWQQRISQYSAVRDNVFRDFFDRVQKPEQDSLIHCLRELFVRSCQVAPQDERQMNLSQCTKRCQRLAIAWLQFEAARYCVDQRLRTTVGKPQETFLGFEAIIMRHARLLSGCAKEIERSALDDLSLEELLSMQSNLSLLLGFLDALEKLIYNAAEGSAFALRPPEKQVAAFFRLNNPTCQSWFNRIRIGVVIIAMHVQQPELVIRYAQQILVNSKTQDPTYSQAIVYMAWSLVSCQEADSLRGLRLWARGKSCKSYKWLKYAADQAAGKRESALAGYRTILAEKELQSELEPHTRQFVVSQMMQCLQDLGQWSQLVELKQQQMTRPEDRELNPFLQRSNVEVNALERLLAKSEESCSSMDALGGVFQQLSLWPSNWDESVSSSGLSERASFSSIHMRQRTEDIVLHKLLEDRCVPDQAKNLLDTQWRDSLLNPSFDQRSCKELTLLRHIVQGVSGGQELSLLPVSSGRCQNRSKFISSAILMRCLAWTQLLRQHCAPGSWETLCLDAAAAAREEGNLQLAETLLTQFFGQPIGEIAALFSLEQGVQTDNPEMLRGYSELVKCLHLQQQQSQTHSGDLSSSIDVCAALCLNIQKSNNQPAAGADLLLNLADWIAVRTCNGLTTNQSPVLIQLLDQLPECPLTCDSSQPLAIPQAERMVARLVHSCLQQRPNYAEALIAYGNWCYRWGKKVADSCCVLTQADATAISQALDIPQPLESEKLDELLQALSTEQPPANCVEVCPDAARARDDEAAKNRLRRLTFLADKTPEALDAILQIWRRAIANTYDYYKDAARSYFQYLSFKSGSGPEKPEGEGVVSQRERLHVDDSNLVTTTLRLLRLIVKHASGLQEVLEQGLHTTPIAPWKVIIPQLFSRLNHHEPYVRKSVCDLLCRLAKSRPQLVIFPAVVGANREQQDATAPPATARPTTEDACCYGYLLGELSKQAPEAVQHVKLMVKELRRVCLLWDEYWIHSLAHIYNTYVSRVSALATDFRPDDHEGKNNRFNVWRPQLLADLEALVAVTSRPPETTYERSFRKRFDAPIRLTVDALRHRRYPEAWDKLKQLYHILQSNMIRGSGSTLKMQSISPVLCGIGRMRISMPGLDAHGPDGDQVYIESVESSVCVLPTKTKPKKVAFYGSNGQRYTFLFKGMEDLHLDERIMQFLSISNAIMACRSDAPGNGCYRAHHYSVIPLGPQSGLISWVDGVTPVFALYKKWQQRRSQVAGNAGAGAVANVPRRFTDLFYNKLSPLLAKHNMQVSDPRRQWPISVLLQVLDELSQETPNDLLARELWCQAGNAAEWRQSVRRFVRCMSVMSMIGYVIGLGDRHLDNVLINLGSGDIVHIDYNVCFEKGRTLRIPEKVPFRLTQNLVQAMGITGIEGPFRLGCEYVLKVMRKERETLLTLLEAFVYDPLVDWTTNDDAQALRRSLNAKLQESADGGGAGGLGVGDLKYHKKDKNKGKPLDSDVKRQPFLSKLGMLQKYWSTNKTELMPQLEEMEQEVGNLQAAQAKQVVAEEELVKLNQRSALIAEIKSLGTAIESHSFNTASLRNAVRRGHSEALALLSTERLPDFGRVQCILRSYGQCLQLYHLLDLQGQLVKLQMESNSENAREFSALTEALQLSGLDSMRSQLNELLGRMDMVAQKSSKHLQEYAGVMNFYPEQSHRQNLFVRFHDSFATYIQNGYTADSTTNTNSPSSSIICKADVVGVAEAMEYSWERLGCQLHEASKLYAANQAQALTLGAPTTALLSMIVQSGCSQLLLKASLVRTLDRAGGAFAAYEQVALASHDDGLLHHQLLFIHLVRTMLQGVLVMTKEEDQHLAQLESLLSALSHLKKMFEYDLPANLYRLLLLQPNLGKLSALCHLSASSLAQLFLEATMENGHKPPDQFPVERRFLLTLQPVYDQFLLASTSLDSLVSSMQSMLEDVHDVQTQQIMELGLMRSCHTELNDECFFGLVSEALESSRTCDVREMARPMLGFIHRLQVEKLAGLLPILTRNFYTAVGPQCLPTASCGDPAQADHLCESLFISLQSDGALLQQQAEIALLSQQVDLHTLAASAQYWAYSEALGSQLRCGPHIVSRPKLTAAIGECWLELDQKLTALQQLQAGLESQLSQLQTQRSNWNRNHIDNLLRMEQCNKQRTMSHVALLQKMTDGAGAVARLEQNAIVVGEEGQALVDHLEQWLAAHGQWQASSSRISAVEQSMVELLDPEGAIDHYWLENVQGLLEEQTCKVHREIAAIEGEQQSKHRFICTLLKETLRLLENMPRFHVQSLCSEAQAQGQGKMEYANVQLLSDHLREGQGLMQSLYMRLQELRKDICSDRRVLQPSMLQNWRHQLEMILTLAKQEVNEFFKGLEDFMQHAGETDSYEIFTHAKGSGNVHEQKRNAYGVSVWKKIRMKLEGRDPDSNQRSTVAEQVDYVIREACNPENLAVLYEGWTPWV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
70	Phosphorylation	AGLGGSESMWSPGGG CCCCCCCCCCCCCCC	27.52	12881430
2027	Phosphorylation	DLFYNKLSPLLAKHN HHHHHHHHHHHHHCC	18.34	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SMG1_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SMG1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SMG1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of SMG1_DROME !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SMG1_DROME

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-70, AND MASSSPECTROMETRY.	18327897 [Abstract]