dbPTM

CNO10_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CNO10_DROME
UniProt AC	Q9V3G6
Protein Name	CCR4-NOT transcription complex subunit 10
Gene Name	Not10
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	635
Subcellular Localization	Cytoplasm. Nucleus.
Protein Description	Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is not required for association of CNOT7 to the CCR4-NOT complex (By similarity)..
Protein Sequence	MDSAESPTKTQAGEDENYSLLCQAHEQFNNSEFDRCLELLQELETRGESSGPVLRHNRAVVSYYKTGCTQHSVLLKELEALTADADAPGDVSSGLSLKQGAAAATVARYNRAVIYYHRHMFGTALEKLAPLVARLEALEKAMAALVATLQLQLLLATNQLNRAEAFLDYLQYKLNLVATAPSSNAAEEAAVVGTAPPSAATNSSVVASPGGAAVEGAVPGLGGSLQLLQLITLVLNRKPVVIQEDGTPEYAALKAQQYYIMKDFQMAAKQLMRINNECTQAGTITPQLSTCIANNMGVIHLRVRHYAIAAKFFQNALNFDQQLARNLRQSTLQTMSSARSCEILYNLGVAMLHLRRPKEAFQCFLVPVKQFHSNPRLWLRMAEACIMEHEAKLVEEERQSQSETPSTKPYAPQSAGVPEPTLEFAVLCLRSALTLTQHYKTRFHMAAVSSEDVEAPEPKDPTQESWRHPQDNNFCNPSKPVSLESLENMMAAIYAAHSFVSLRLGDHVTALEMSEKLLACERLSDAHKLLGHMYAGEALMLMDKASEARDHLDPTFVGTLNAFDFETRDWQLKSVDAAQNVVRYNLAVAMALQNDLPQAKALLANLTHSLVANKALALRRFMDLKMGPVPGGTPS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
45	Phosphorylation	ELLQELETRGESSGP HHHHHHHHCCCCCCC		17372656

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CNO10_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CNO10_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CNO10_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ACT1_DROME	Act5C	physical	14605208
RL18_DROME	RpL18	physical	14605208
CNO10_DROME	Not10	physical	23303381

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CNO10_DROME

Related Literatures of Post-Translational Modification