NOI_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NOI_DROME
• UniProt AC: O46106
• Protein Name: Splicing factor 3A subunit 3
• Gene Name: noi
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 503
• Subcellular Localization: Nucleus. Excluded from the nucleoli.
• Protein Description: Probable subunit of a splicing factor complex required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA (By similarity). Involved in male fertility..
• Protein Sequence: METLLEQQRRLHEERERLVKLMVDEHATKKPGEKERIHSEHRLKYLMELHHNSTSQLRDLYEDKDNERKAEIAALSGPNEFNEFYARLKQIKQFYKSHPAEVSVPLSVEFDEMIRVYNNPDDMSALVEFTDEEGGGRYLDLNECYELYLNLRSVEKLDYITYLMSFDHVFDIPRERKNREYRIYIETLNDYLHHFILRIQPLLDLEGELLKVELDFQRQWLMGTFPGFSIKETESALANTGAHLDLSAFSSWEELASLGLDRLKSALVALGLKCGGTLEERAQRLFSTKGKSTLDPALMAKKPSAKTASAQSREHERHKEIAQLEALLYKYADLLSEQRAATKENVQRKQARTGGERDDSDVEASESDNEDDPDADDVPYNPKNLPLGWDGKPIPYWLYKLHGLNISYNCEICGNFTYKGPKAFQRHFAEWRHAHGMRCLGIPNTAHFANVTQIEDAITLWEKLKSQKQSERWVADQEEEFEDSLGNVVNRKTFEDLKRQGLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
353	Phosphorylation	VQRKQARTGGERDDS HHHHHHHHCCCCCHH	53.18	23607784
360	Phosphorylation	TGGERDDSDVEASES HCCCCCHHHCCCCCC	48.09	19429919
365	Phosphorylation	DDSDVEASESDNEDD CHHHCCCCCCCCCCC	24.91	19429919
367	Phosphorylation	SDVEASESDNEDDPD HHCCCCCCCCCCCCC	43.15	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NOI_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NOI_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NOI_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CRN_DROME	crn	physical	14605208
RNK_DROME	CG40127	physical	14605208
TAD2B_DROME	Ada2b	physical	14605208

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-360; SER-365 ANDSER-367, AND MASS SPECTROMETRY.
PubMed: 18327897