TIG_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TIG_DROME
• UniProt AC: Q9VMD9
• Protein Name: Tiggrin {ECO:0000312|EMBL:AAF52380.2}
• Gene Name: Tig {ECO:0000312|EMBL:AAF52380.2, ECO:0000312|FlyBase:FBgn0011722}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 2188
• Subcellular Localization: Secreted, extracellular space, extracellular matrix . Localizes to the basal surface of the dorsoventral cell layer interface during pupal wing development.
• Protein Description: Functions as a ligand for integrin alpha-PS2/beta-PS. Required in larvae for proper muscle structure and function. Involved in the regulation of cell adhesion during wing development..
• Protein Sequence: MRALGGITLLLAVAICQGYETYQRSSFRSSSSSSYGGGQTVPQLNSFASAHFNEVRELANQLKQKFNVLSQGSTNFAYTSPWSASILDLSGKSTLQLDQLSSEISRQLVQDMREGITNYHTIAQPNFFEAKAAELLERYSGAESASLQQTVGLGPYQPVDLSGFDEVKNYAYPAEVKVIDGKTYVVHRNCTEATKLSDYGSSGQLNSGFLGHQQTSLPLSSTTTTITRKKTIHDWVRENMEPSVVGYNSVVKLDGQLRNSALNQMVPLSPGSNVVIHRFNKTITTNPDGTSSVGGSEWQQRWQDGKLVYDHQQPFGQSTIPRDEQWKREERERLFWYLTTPQRLDDWQQQQEERLLGVVQRYQVSLPVLKEFHRRELARYEALLGQYQSRVQDTSSWQRQERGRLDWLIHQNGFTVQDIERWQNENARKLAEAARQHGISQNQLQQFQREELQRLYVHFNQVNESLAPQVPSVPQTTYNYQSSSSLTEDNTKEQQRLEELIRQHNATIAALQNSIKTDQQRLKNLSIKYQGDMQSQTQWLRGEVARIGDLIKEQNEQVSKITAWQSSERSRLENILLQHRGSVEEVQQRINMDRNYLQNLATKYQVSVEELEKWQKEELERLQVRGQQQLEEHIKDWQISVSSNLRDIATQNKLTIDEFQNYIINDRSHLEEMARLYKVKVEEIEQWIKSELKKFQSEGLLKGVEQELIQWQQKERERLQAIVQQNSLTVEQLEVRIKNDQDHFFKLADKYKINVEDIQDWLKKELLRLQSEGLVKAETLKEWQQQERAQISLLVQQNKYSLDEFERKMLADRARLQELSNTYNVKVSEIEQWIKSEGDRLQHEGQLRMESQLNNWQKIERQRLLDLINKNNLSIEEIESKISKDQTHLYSLAQQHQVRVEEIEQWIRQQIQKLQDQGLIEMQKLKNWQLEWRGNLTNMVQDRDFTVEEFHKWLLKDREQLQSLAMQHNVQIEEIEQFVKKEEQRFIGMGLLKPSEKLTNWQEVERLHLKNLAQQQYKSTEQLEARLRQDRELLERLARQYSVQVEEIESWMKQELARMRDEGQLQIDNLTSWQLAERERLEALIKQNKQWSAEELRAELEKDREHMQTMAFQYHTSVEEIEKWLQSEIERLKQQGKLNIEQLTAWQRTEQQRILSLLQQHSNITLEQFQAKVHNDRRFLMNLAEQHHVHIEEVDNYVKQVIEDLRKNGQFEIEQLQTWQRVERDYIKSLISEYKNSLSTAEYEEKLLADRAHLKHLADQYRINVEQIEEWMIAELKRLRGSTEETLKSLSAWQVSELERLQNLVKQQNHLTFVEFEMELNQERDRLQKLANQYSVNVVEIEEWLRQQLINLRTTGQAKVENLSKWQVEEQQRLIEMLLKKQQEMPYEQVERELTQDHARLQSLSQTHHVDIDHVDHWLREELRRLQSSGLVQIEQQTQWQQKISNGFNNWLEQQRNGASYQDFVDFLKRDKQRMDGIATDYHVTVEQVEKWVQKEAARLSLIGVIERPENNLKYEDISNIWVGDQTDSWKNELVTRLRSVTRQRPFTRQEFESYLIRNKPIFEQIARQYHVTIEDIHLWLDQSAKNEGLVTTEWQAKERLHIDNLINQQLRKQQRWTIEELELRLNNDQKHLQDAVAQYHVTVEELKVWYKDELNRLLEQRRIDRGSGISWQNIESQRIYLAIVNNPGISRQALENRLFRDVHVRASQYQITVEELRQFILSQLRRFSDMGLIVDNGRQANNWHDQERKRLREVVKGVVITEQELLDFISQDTSFQTQLAQSYQVGLEQLAPVQRIFIGNLAREQLLEQRRLNHLTTWQQRERDRLYEFIGNQNMTQTELKTWQIQDSKLLAEFAKRYEISVQQLSDWQKKELARINQLARYYGMSQSDLQQFREGELRQLAYINHRQLLSAAEAQKWEKRHQWTLSRLQSRYGKFGQELVAWRRTLYLLSQGLIDLPADSGSNGGYVVDAGSTNATAVYKPIFSKDRGDQPPHTYDESFVEGDEPGLEGETARPRPPNPAPIVSTPKPPLPYSRGGPSGGFEYRRQDYTFNVPVGSASASASGGPTGSSASASASLGKWNRASGDEPLQQEVDLGQQQQIEELGWNEKLEDLGQQTQVEDTDWNQQAEDLGQQQQVQVEDDLHFDQTQGHSSSSNSRSQPLQQATKVEVEATSEPSFWEKLKEKLG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
269	Phosphorylation	LNQMVPLSPGSNVVI HHCCCCCCCCCCEEE		22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TIG_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TIG_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TIG_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.