M3KSL_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: M3KSL_DROME
• UniProt AC: Q95UN8
• Protein Name: Mitogen-activated protein kinase kinase kinase
• Gene Name: slpr {ECO:0000312|FlyBase:FBgn0030018}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1161
• Protein Description: Activates the JUN N-terminal pathway during dorsal closure..
• Protein Sequence: MPSQVSRGLDTTNMLPISEEQQLQQQQQQQQLEQLHHPQIPEIPIPDLEQVETQVGDGSLWTALYDYDAQGEDELTLRRGEIVVVLSTDSEVSGDVGWWTGKIGDKVGVFPKDFVTDEDPLQLNVSSAIGDIQPHEIEYNELDIKEVIGSGGFCKVHRGYYDGEEVAIKIAHQTGEDDMQRMRDNVLQEAKLFWALKHENIAALRGVCLNTKLCLVMEYARGGSLNRILAGKIPPDVLVNWAIQIARGMNYLHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLAREMYNTQRMSAAGTYAWMPPEVISVSTYSKFSDVWSYGVLLWELITGETPYKGFDPLSVAYGVAVNTLTLPIPKTCPETWGALMKSCWQTDPHKRPGFKEILKQLESIACSKFTLTPQESFHYMQECWRKEIAGVLHDLREKEKELRNKEEQLLRVQNEQREKANLLKIREQNLRERERVLIERELVMLQPVPSKRKHKKGKKNKPLQISLPTGFRHTITAVRDKAEQPGSPSFSGLRIVALTDGHKGKTWGPSTMHQRERSLLPSQLSGGQPEWPAQTSTHSSFSKSAPNLDKKQQQQNQQQVASLTPPPGLGILGGSGGAGGTPATPLLYPGIPIILTRPNNNNIGNCKAITTTITTTTTTTTNNNNNNNNSISANNNNQLNNISTINSNNNNNQTNLTSQPNTIIVLQNGRNNSNSSTTSQSPAKIYHRARSQEYGLDHPLAYQPPPLYLVTDDSSETDTVASPTGCFHFLKSGNSSAASGAVHLHRFGGSLGNSPAVGRKKHSLDSSSHHPPANGSNSFALPNQLTLPSEDNNTYDHAFYRDVIKKMSMASSERVNSKSSGDLTMYNSSTPLTARDCDDAEEAFEGGRFQRNFSGSQFPRHCFFTRQEEEGEAEDEDAVAAEVDTADADADDECQVPASQMRQNSTTSRKSSVTFQSVSFEEPDFVATPRTTARSDLYTSSASISFATYRSASPSLSSSSTTASASPSIASTEAVNGYHMQENSILNTRRMQDVQPHPDVIKLRAQEQRQQTKNQKKQRPKHITKSKSVEAPVEGQHHEHDDHNDPQHQHHSAGSSKIRALFNLFTRSRKKYSKLAEHNMVGGPEFCAIDPYQTDLAMGGSSRSLKRKGKKPQTQSCEQLERC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
300	Phosphorylation	LAREMYNTQRMSAAG HHHHHHHCCCCCCCC	10.48	-
304	Phosphorylation	MYNTQRMSAAGTYAW HHHCCCCCCCCCCCC	19.70	-
414	Phosphorylation	FTLTPQESFHYMQEC CCCCCHHHHHHHHHH	16.45	22817900
512	Phosphorylation	LPTGFRHTITAVRDK CCCCCCCEEEEEHHH	18.77	21082442
525	Phosphorylation	DKAEQPGSPSFSGLR HHCCCCCCCCCCCCE	24.85	22817900
544	Phosphorylation	TDGHKGKTWGPSTMH CCCCCCCCCCCCHHH	44.30	19429919
560	Phosphorylation	RERSLLPSQLSGGQP HHHHCCHHHHCCCCC	43.66	-
582	Phosphorylation	THSSFSKSAPNLDKK CCCCCCCCCCCCCHH	48.00	29892262
685	Phosphorylation	NNISTINSNNNNNQT CCCEEEECCCCCCCC	36.76	-
724	Phosphorylation	SQSPAKIYHRARSQE CCCHHHHHHHHHHHH	5.64	18281928
773	Phosphorylation	HFLKSGNSSAASGAV EEECCCCCCHHCCCE	25.53	-
788	Phosphorylation	HLHRFGGSLGNSPAV EEHHCCCCCCCCCCC	33.22	25749252
792	Phosphorylation	FGGSLGNSPAVGRKK CCCCCCCCCCCCCCC	16.67	29892262
801	Phosphorylation	AVGRKKHSLDSSSHH CCCCCCCCCCCCCCC	42.63	22817900
858	Phosphorylation	ERVNSKSSGDLTMYN CCCCCCCCCCCEECC	39.81	27626673
862	Phosphorylation	SKSSGDLTMYNSSTP CCCCCCCEECCCCCC	23.50	22817900
892	Phosphorylation	GRFQRNFSGSQFPRH CCCEECCCCCCCCCE	40.87	19429919
894	Phosphorylation	FQRNFSGSQFPRHCF CEECCCCCCCCCEEE	27.70	27626673
949	Phosphorylation	NSTTSRKSSVTFQSV CCCCCCCCCEEEEEE	29.00	21082442
950	Phosphorylation	STTSRKSSVTFQSVS CCCCCCCCEEEEEEE	28.36	21082442
993	Phosphorylation	TYRSASPSLSSSSTT EEECCCCCCCCCCCC	38.09	-
1152	Phosphorylation	RKGKKPQTQSCEQLE HCCCCCCCCCHHHHH	30.86	29892262
1154	Phosphorylation	GKKPQTQSCEQLERC CCCCCCCCHHHHHCC	24.02	25749252

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of M3KSL_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of M3KSL_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of M3KSL_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HEP_DROME	hep	genetic	19064708
POK_DROME	aop	genetic	16888342
JRA_DROME	Jra	genetic	11825878
M3K7_DROME	Tak1	genetic	16888342
M3K7_DROME	Tak1	genetic	24429281
JNK_DROME	bsk	genetic	16888342
FOSLD_DROME	kay	genetic	16888342
FOSLA_DROME	kay	genetic	16888342

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-525 AND THR-862, ANDMASS SPECTROMETRY.
PubMed: 18327897