dbPTM

NOL6_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NOL6_DROME
UniProt AC	Q8IH00
Protein Name	Nucleolar protein 6 {ECO:0000250\|UniProtKB:Q9H6R4}
Gene Name	Mat89Ba {ECO:0000303\|PubMed:9799434}
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	1193
Subcellular Localization	Nucleus, nucleolus .
Protein Description
Protein Sequence	MRFVQGNIMPGKLVGSPKGAARTGTQAIAHAGDHSDLDEPKPKIAKSDPPSTAIPKKNNFKQREGTKNVKPPTLEEMKELRDTQNLFHSNLFKLQVKEMLEELQLKQKYTDFIENWLESFTAFTRQLKDGLMERTHLEVPMKLSEKPTGFVFSKPTREPYLIGAAATGTLLGPKIVVDVALEMPKESLHKEDYLNLRYDQKRALYLTYVTERMMESPDYAEDQFNFNYYANNPLKPVLELIPVTKQVNKHLQVRLFITAPLSSFKPGRFVPWNNNIRPSFYGDEWDEKDPLPSTQHYNANVLFDLTLSENQAQLDKAFKSRRNFQDGLLLLKVWLRQRQLDIGYSGFGAHILAAFIVYLNTQRILHQSSSSYQVARTVWNQLANTDWTKGISLSVAPIQTEELNKFAEHYDVCFIDFTGQHNLCANIPLYLYQRVREEAKLAVELLNDMKLNSFPLIFMQKCPLYSRVDNILKISNYSCINQMLTLHSHPRIKYDFANYGYPQLLHLLTELLKKGLAERVHSILPLETATAAWPVEKKAPVIGKYIQLGLILQPEHAYQVLNKGPAANDDHEGAEEFRRFWGEKSNLRRFQDGSITEAVVWGTAQDSPAKKRLIVRQIVLHLLEHHLQLDSKEVQYIGGELDQVYQLSPWFKVNKLKTKLPLGQDTDAEALSPHVIRCYDELARQLHGLNDLPLEIVSISGVSPIFRYCEPQPVLPQALLVENRILASSIQRVVIQLGQSGKWPTELGALRALKTAFLIEIGEKLEAQCRLHWVMSADGLLVLKQGYCFLIELAHNKELALLKQEVTERGITTYIDNAASRSLERQHYILPKVSGALHSLHQTYSAFGSTVLLAKRWLATQLLDDGLWPDMATELLVAHLFQQRYAPQSIAAPQTGFIRFLQLLSHSDFNGELFLLNFNNSWQEQQIADLEHNYRSNRQSYPPLAVATSYDMQHAGRLWTSDQSPSQRVLGHVTRLARHALEIIETSLMSKDLRFVRPAQLFRASNEGYDLVIQFKPDLVPNSLSYDLGSPFVSFSQPNFSLPRAGSDYIARIVGLLRSAYSDFAAFFYNPHGGKELGIVWRPPTEFAAKPFKVTELQACSPCGNKKVQVLKETLLEDFKLLLKDFYLRIATPEELKREQREHQKPMRYFDANKAEEESKPKPKKHRQRKGTGKKALPKRKRLIKSSTLKVLK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Phosphorylation	SPKGAARTGTQAIAH CCCCCCCCCCHHHHC	39.59	23607784
25	Phosphorylation	KGAARTGTQAIAHAG CCCCCCCCHHHHCCC	17.76	22668510
35	Phosphorylation	IAHAGDHSDLDEPKP HHCCCCCCCCCCCCC	44.61	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NOL6_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NOL6_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NOL6_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of NOL6_DROME !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NOL6_DROME

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-35, AND MASSSPECTROMETRY.	18327897 [Abstract]