ZFH2_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZFH2_DROME
• UniProt AC: P28167
• Protein Name: Zinc finger protein 2
• Gene Name: zfh2
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 3005
• Subcellular Localization: Nucleus .
• Protein Description: Involved in the development of the embryonic central nervous system..
• Protein Sequence: MSSFDVETFNGKIVYNLDGSAHIIATDNTNGGGSGSGQNCYGSTTNSLKNLSKDKGRGQEEKDIEHPSQYHREQSDNKRQEEAVDNRPGVESLGSACYKSSPKIHSFRVVSAQDANSTCQDQIRAFKIQKPILMCFICKLSFGNVKSFSLHANTEHRLNLEELDQQLLNREYSSAIIQRNMDEKPQISFLQPLANNDASADTNDTEKLQTATEGSDATLPSSPQPVFRNVSELEPENKQETEQNRLLNQDREQEPESDQHTSSSKMAAPSAYIPLSSPKVAGKLTVKFGSLNSATAKTNNLSKVSSTSSPPSTYASGEVLSPSTDNISNHKSTHCNQETEPPSSSSSEVEMKIGSMSTSPQTNDSDVPCSGFLQMQHMTTGGAYTPQVSSFHASLAALAANESNDNRVKLITEFLQQQLQQHQSSLFPSPCPDHPDLNGVDCKTCELLDIQQRSKSPSSSHHQFSQSLPQLQIQSQPQQTPHRSPCSNSVALPVSPSASSVASVGNASTATSSFTIGACSEHINGRPQGVDCARCEMLLNSARLNSGVQMSTRNSCKTLKCPQCNWHYKYQETLEIHMREKHPDGESACGYCLAGQQHPRLARGESYSCGYKPYRCEICNYSTTTKGNLSIHMQSDKHLNNMQELNSSQNMVAAAAAAAVTGKLLLSSSSPQVTAACPSNSGSGAGSGSSNIVGGTASLSGNATPSVTGANSSNANAGSNTNNAGTKPKPSFRCDICSYDTSVARNLRIHMTSEKHTHNMAVLQNNIKHIQAFNFLQQQQQSGTGNIASHSSGSFMPEVALADLAYNQALMIQLLHQQQQHQQSANTKLSPSSSPVSTPDQFSFSPKPIKLNHGTGAAMGIGMAMGMGMSHSNEVSCELSGDPHPLTKTDKWPMAFYSCLVCDCYSTNNLDDLNQHLLLDRSRQSSSASSEIMVIHNNNYICRLCNYKTNLKANFQLHSKTDKHLQKLNFINHIREGGPQNEYKMQYQQQQLAANVVQLKCNCCDFHTNSIQKLSLHTQQMRHDTMRMIFQHLLYIVQQSEMHNKSSGSAEDDPQCACPDEDQQLQLQSSKKLLLCQLCNFTAQNIHEMVQHVKGIRHLQVEQFICLQRRSENQEIPALNEVFKVTEWVMENEDVSLAPGLNLARTTTNDATTDASYAAASSAAVPAIPDVSMFSPTSPSSCATSCDKNLSQIVLPNVNNLGSGVPTTVFKCNLCEYFVQSKSEIAAHIETEHSCAESDEFITIPTNTAALQAFQTAVAAAALAAVHQRCAVINPPTQDTVDEDKDLDTNVSDGPVGIKQERLEQEVDRTTSMDVTKDLASQATDFGAPESPKVAETEVGVQCPLCLENHFREKQYLEDHLTSVHSVTRDGLSRLLLLVDQKALKKESTDIACPTDKAPYANTNALERAPTPIENTCNVSLIKSTSANPSQSVSLQGLSCQQCEASFKHEEQLLKHAQQNQHFSLQNGEYLCLAASHISRPCFMTFRTIPTMISHFQDLHMSLIISERHVYKYRCKQCSLAFKTQEKLTTHMLYHSMRDATKCSFCQRNFRSTQALQKHMEQAHAEDGTPSTRTNSPQTPMLSTEETHKHLLAESHAVEREVSGSDVSPIELETHLNKETRHLSPTPMSLDSQSHQKHLATFAALLKQQQCNSDAGGLHPEALSMSTGEMPPQLQGLQNLQHIQQHFGAVAAAAGLPINPVDMLNIMQFHHLMSLNFMNLAPPLVFGANAAGNAVSGPSALNNSITTSTATSASGLGDTHLTSGVSSIPVDSGKATAVPPQTQLNANANSQQLASNQKRARTRITDDQLKILRAHFDINNSPSEESIMEMSQKANLPMKVVKHWFRNTLFKERQRNKDSPYNFNNPPSTTLNLEEYERTGQAKVTPLNDTCSVAVTGPMTSSTISLPPSGNINLSSKENATSKVLAAGKANASGPVTFSATVPVSTPLSRPESTNSSGNISDYIGNNIFFGQLGSKEQILPYSLDGQIKSEPQDDMIGATDFAYQTKQHSSFSFLKQQQDLVDPPEQCLTNQNADTAQDQSLLAGSSLASNCQSQQQINIFETKSESGSSDVLSRPPSPNSGAAGNVYGSMNDLLNQQLENMGSNMGPPKKMQIVGKTFEKNVAPMVTSGSVSTQFESNSSNSSSSSSSTSGGKRANRTRFTDYQIKVLQEFFENNSYPKDSDLEYLSKLLLLSPRVIVVWFQNARQKQRKIYENQPNNTLFENEETKKQNINYACKKCNLVFQRYYELIRHQKNHCFKEENNKKSAKAQIAAAQIAQNLSSEDSNSSMDIHHVGICPPGSAVASHTLSTPGSAAPLPGQYTQHSFGALPSPQHLFAKSSSLTDFSPSTTPTPPQRERSNSLDQIQRPPKFDCDKCELNFNQLEKLREHQLLHLMNPGNICSDVGQNSNPEANFGPFGSILQSLQQAAAQQQQQHHQQPPTKKRKYSDCSSNADEMQSLSELEASQKKHEYLYKYFMQNETSQEVKQQFLMQQQQKKLEQGNECDFELDFLTNFYQQNELKKVSNYDFLLQYYRTHEEAKSSQQHTFSSSKKPTIEFLLQYYQLNESKKFFQLVASPQIIPDVPGYKPSLRIPKSTSDEAPYIGETSLEQATELQREKQDEQLRIDRPSEENDLSMNKNKVENINNNNINVDQSNLTETNGGVPSVETKEECTQESSLIAMDDENKYLCTRSKQKDDKEKSHYLHNLEDFLDATMIENNSQTLTFNDDEKACQKDELTQNSNAIEKRSSVSPVNVSSKQNKRLRTTILPEQLNFLYECYQSESNPSRKMLEEISKKVNLKKRVVQVWFQNSRAKDKKSRNQRHYAHISDDNSYDGSSGKEVYSDLRSNGITVDTDLETNLQDCQLCQVTQVNIRKHAFSVEHISKMKKLLEQTTELYAQSNGSGSEDNDSDREKRFYNLSKAFLLQHVVTNATSHAIHTARQDSDVIAEGNCILNYDTNGGDSKSHVQHNLPNEVVSEDARKIAGNQELMQQLFNRNHITVIGGK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
221	Phosphorylation	GSDATLPSSPQPVFR CCCCCCCCCCCCCCC	58.73	29892262
222	Phosphorylation	SDATLPSSPQPVFRN CCCCCCCCCCCCCCC	26.14	29892262
276	Phosphorylation	PSAYIPLSSPKVAGK CCCCCCCCCCCCCCE	38.96	29892262
277	Phosphorylation	SAYIPLSSPKVAGKL CCCCCCCCCCCCCEE	36.10	22817900
1299	Acetylation	SDGPVGIKQERLEQE CCCCCCCCHHHHHHH	39.93	21791702
1331	Phosphorylation	TDFGAPESPKVAETE CCCCCCCCCCCEECC	29.03	29892262
1337	Phosphorylation	ESPKVAETEVGVQCP CCCCCEECCCCCCCC	26.66	18327897
1411	Phosphorylation	NALERAPTPIENTCN CHHHCCCCCCCCCEE	35.59	22817900
1576	Phosphorylation	TPSTRTNSPQTPMLS CCCCCCCCCCCCCCC	20.12	29892262
1579	Phosphorylation	TRTNSPQTPMLSTEE CCCCCCCCCCCCCHH	17.66	29892262
1624	Phosphorylation	NKETRHLSPTPMSLD CCCCCCCCCCCCCCC	22.17	21082442
1839	Acetylation	QKANLPMKVVKHWFR HHCCCCHHHHHHHHH	41.77	21791702
2117	Acetylation	KKMQIVGKTFEKNVA HHCEEECCEECCCCC	38.86	21791702
2359	Phosphorylation	TPPQRERSNSLDQIQ CCCCHHCCCCHHHCC	26.47	21082442
2361	Phosphorylation	PQRERSNSLDQIQRP CCHHCCCCHHHCCCC	34.27	22817900
2447	Phosphorylation	PTKKRKYSDCSSNAD CCCCCCCCCCCCCHH	34.87	22817900
2450	Phosphorylation	KRKYSDCSSNADEMQ CCCCCCCCCCHHHHH	31.45	22817900
2451	Phosphorylation	RKYSDCSSNADEMQS CCCCCCCCCHHHHHH	42.22	22817900
2748	Phosphorylation	SNAIEKRSSVSPVNV CCHHHHHCCCCCCCC	46.27	29892262
2749	Phosphorylation	NAIEKRSSVSPVNVS CHHHHHCCCCCCCCC	30.55	22817900
2751	Phosphorylation	IEKRSSVSPVNVSSK HHHHCCCCCCCCCHH	25.69	25749252

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZFH2_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZFH2_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZFH2_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1337; SER-2361;SER-2450; SER-2451; SER-2749 AND SER-2751, AND MASS SPECTROMETRY.
PubMed: 18327897