HMEN_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HMEN_DROME
• UniProt AC: P02836
• Protein Name: Segmentation polarity homeobox protein engrailed
• Gene Name: en
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 552
• Subcellular Localization: Nucleus .
• Protein Description: This protein specifies the body segmentation pattern. It is required for the development of the central nervous system. Transcriptional regulator that represses activated promoters. Wg signaling operates by inactivating the SGG repression of EN autoactivation..
• Protein Sequence: MALEDRCSPQSAPSPITLQMQHLHHQQQQQQQQQQQMQHLHQLQQLQQLHQQQLAAGVFHHPAMAFDAAAAAAAAAAAAAAHAHAAALQQRLSGSGSPASCSTPASSTPLTIKEEESDSVIGDMSFHNQTHTTNEEEEAEEDDDIDVDVDDTSAGGRLPPPAHQQQSTAKPSLAFSISNILSDRFGDVQKPGKSMENQASIFRPFEASRSQTATPSAFTRVDLLEFSRQQQAAAAAATAAMMLERANFLNCFNPAAYPRIHEEIVQSRLRRSAANAVIPPPMSSKMSDANPEKSALGSLCKAVSQIGQPAAPTMTQPPLSSSASSLASPPPASNASTISSTSSVATSSSSSSSGCSSAASSLNSSPSSRLGASGSGVNASSPQPQPIPPPSAVSRDSGMESSDDTRSETGSTTTEGGKNEMWPAWVYCTRYSDRPSSGPRYRRPKQPKDKTNDEKRPRTAFSSEQLARLKREFNENRYLTERRRQQLSSELGLNEAQIKIWFQNKRAKIKKSTGSKNPLALQLMAQGLYNHTTVPLTKEEEELEMRMNGQIP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
394	Phosphorylation	IPPPSAVSRDSGMES CCCCCCCCCCCCCCC	30.04	7744743
397	Phosphorylation	PSAVSRDSGMESSDD CCCCCCCCCCCCCCC	38.64	7744743
401	Phosphorylation	SRDSGMESSDDTRSE CCCCCCCCCCCCCCC	30.12	7744743
402	Phosphorylation	RDSGMESSDDTRSET CCCCCCCCCCCCCCC	26.63	7744743

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
394	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
394	S	Phosphorylation	Kinase	CKII_GROUP	-	PhosphoELM
397	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
397	S	Phosphorylation	Kinase	CKII_GROUP	-	PhosphoELM
401	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
401	S	Phosphorylation	Kinase	CKII_GROUP	-	PhosphoELM
402	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
402	S	Phosphorylation	Kinase	CKII_GROUP	-	PhosphoELM

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HMEN_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HMEN_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EXD_DROME	exd	genetic	12506004
HMIN_DROME	inv	genetic	9108369
ERF1_DROME	eRF1	genetic	14573473
HTH_DROME	hth	genetic	12506004
GROU_DROME	gro	physical	11311161
GROU_DROME	gro	physical	16762837
GROU_DROME	gro	physical	9367988
GROU_DROME	gro	physical	9566899
CLASP_DROME	chb	physical	25242320

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.