GLI3_MOUSE - dbPTM
GLI3_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GLI3_MOUSE
UniProt AC Q61602
Protein Name Transcriptional activator GLI3
Gene Name Gli3
Organism Mus musculus (Mouse).
Sequence Length 1583
Subcellular Localization Nucleus . Cytoplasm . Cell projection, cilium . Translocation to the nucleus is promoted by interaction with ZIC1 (By similarity). GLI3FL is localized predominantly in the cytoplasm while GLI3R resides mainly in the nucleus. Ciliary accumulation requ
Protein Description Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in regulating the size of the zone of distal chondrocytes, in restricting the zone of PTHLH expression in distal cells and in activating chondrocyte proliferation. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'..
Protein Sequence MEAQAHSSTATERKKAENSIGKCPTRTDVSEKAVASSTTSNEDESPGQIYHRERRNAITMQPQSVQGLNKISEEPSTSSDERASLIKKEIHGSLPHLAEPSLPYRGTVFAMDPRNGYMEPHYHPPHLFPAFHPPVPIDARHHEGRYHYDPSPIPPLHVPSALSSSPTYPDLPFIRISPHRNPTAASESPFSPPHPYINPYMDYIRSLHSSPSLSMISAARGLSPTDAPHAGVSPAEYYHQMALLTGQRSPYADILPSAATAGAGAIHMEYLHAMDSTRFPSPRLSARPSRKRTLSISPLSDHSFDLQTMIRTSPNSLVTILNNSRSSSSASGSYGHLSASAISPALSFTYPSAPVSLHMHQQILSRQQSLGSAFGHSPPLIHPAPTFPTQRPIPGIPTVLNPVQVSSGPSESSQSKPTSESAVSSTGDPMHNKRSKIKPDEDLPSPGSRGQQEQPEGTTLVKEEADKDESKQEPEVIYETNCHWEGCTREFDTQDQLVHHINNDHIHGEKKEFVCRWLDCSREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCTKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHVTKKQRGDMHPRPPPPRDSGSHSQSRSPGRPTQGAFGEQKELSNTTSKREECLQVKTVKAEKPMTSQPSPGGQSSCSSQQSPISNYSNSGLELPLTDGGSVADLSAIDETPIMDSTISTATTALALQARRNPAGTKWMEHIKLERLKQVNGMFPRLNPILPSKAPAVSPLIGNGTQSNNNYSSGGPGTLLPSRSDLSGVDFTVLNTLNRRDSNTSTISSAYLSSRRSSGISPCFSSRRSSEASQAEGRPQNVSVADSYDPISTDASRRSSEASQGDGLPSLLSLTPVQQYRLKAKYAAATGGPPPTPLPHMERLSLKTKMALLGEGRDSGVTLPPVHPPRRCSDGGGHTYRGRHLMPHDALANSVRRASDPVRTVSENMSLARVQRFSSLNSFNPPNLPPSVEKRSLVLQNYTRQESSQPRYFQASPCPPSITENVALEALTMDADANLNDEDLLPDDVVQYLNSQNQTGYGQQLQSGISEDSKVAHEPEDLDLAGLPDSHVGQEYPALEQPCSEGSKTDLPIQWNEVSSGTSDLSSSKLKCGQQRPSAQQPRGFGLYNNMVVHPHNLWKVGTGPAGGYQTLGENSSTYNGPEHFAIHSGDGLGTNGNTFHEQPFKTQQYGSQLNRQPLTSSALDHACGTGIQGSKLKGNSLQENGGLLDFSLSVAPNELAGNTVNGMQTQDQMGQGYIAHQLLSGSMQHQGPSRPGQQVLGQVGATSHINIYQGTESCLPGTQDNSSQPSSMAAIRGYQPCASYGGNRRQAMPRGNLTLQQGQLSDMSQSSRVNSIKMEAQGQSQQLCSTVQNYSGQFYDQTMGFSQQDRKAGSFSLSDANCLLQGNGTENSELLSPGANQVTSTVDSFESHDLEGVQIDFDAIIDDGDHTSLMSGALSPSIIQNLSHSSSRLTTPRASLPFPSLSMGTTNMAIGDMSSLLTSLAEESKFLAVMQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MEAQAHSS
-------CCCCCCCC		42.17-
39PhosphorylationKAVASSTTSNEDESP
HHHHCCCCCCCCCCC		31.3525338131
40PhosphorylationAVASSTTSNEDESPG
HHHCCCCCCCCCCCC		38.0125338131
45PhosphorylationTTSNEDESPGQIYHR
CCCCCCCCCCCCCCH		46.8025338131
78PhosphorylationISEEPSTSSDERASL
HCCCCCCCHHHHHHH		39.8829514104
79PhosphorylationSEEPSTSSDERASLI
CCCCCCCHHHHHHHH		43.5128059163
93PhosphorylationIKKEIHGSLPHLAEP
HHHHHHCCCCCCCCC		25.2721659605
146PhosphorylationARHHEGRYHYDPSPI
CCCCCCCCCCCCCCC		18.6525777480
148PhosphorylationHHEGRYHYDPSPIPP
CCCCCCCCCCCCCCC		22.1825777480
151PhosphorylationGRYHYDPSPIPPLHV
CCCCCCCCCCCCCCC		32.3425777480
160PhosphorylationIPPLHVPSALSSSPT
CCCCCCCCCCCCCCC		40.5325777480
163PhosphorylationLHVPSALSSSPTYPD
CCCCCCCCCCCCCCC		28.6125777480
164PhosphorylationHVPSALSSSPTYPDL
CCCCCCCCCCCCCCC		40.9825777480
165PhosphorylationVPSALSSSPTYPDLP
CCCCCCCCCCCCCCC		20.2026824392
167PhosphorylationSALSSSPTYPDLPFI
CCCCCCCCCCCCCCE		50.0325777480
168PhosphorylationALSSSPTYPDLPFIR
CCCCCCCCCCCCCEE		9.7225777480
175MethylationYPDLPFIRISPHRNP
CCCCCCEEECCCCCC		24.5824129315
191PhosphorylationAASESPFSPPHPYIN
CCCCCCCCCCCCCCC		40.6925338131
223PhosphorylationISAARGLSPTDAPHA
HHHHCCCCCCCCCCC		28.6929514104
295PhosphorylationPSRKRTLSISPLSDH
CCCCCEEEECCCCCC		22.0229514104
312PhosphorylationDLQTMIRTSPNSLVT
CHHHHEECCCCCEEE		37.3025338131
445PhosphorylationKPDEDLPSPGSRGQQ
CCCCCCCCCCCCCCC		49.5527087446
448PhosphorylationEDLPSPGSRGQQEQP
CCCCCCCCCCCCCCC		36.3025619855
565PhosphorylationSRLENLKTHLRSHTG
HHHHHHHHHHHHHCC		29.34-
588PhosphorylationEGCNKAFSNASDRAK
CCCCHHHCCHHHHHH		36.02-
591PhosphorylationNKAFSNASDRAKHQN
CHHHCCHHHHHHHCC		31.70-
658PhosphorylationPPPRDSGSHSQSRSP
CCCCCCCCCCCCCCC		24.74-
660PhosphorylationPRDSGSHSQSRSPGR
CCCCCCCCCCCCCCC		31.3925338131
662PhosphorylationDSGSHSQSRSPGRPT
CCCCCCCCCCCCCCC		37.4327717184
664PhosphorylationGSHSQSRSPGRPTQG
CCCCCCCCCCCCCCC		36.6328507225
669PhosphorylationSRSPGRPTQGAFGEQ
CCCCCCCCCCCCCCC		37.9727149854
849PhosphorylationNTLNRRDSNTSTISS
ECCCCCCCCCCCCCH		39.9525168779
851PhosphorylationLNRRDSNTSTISSAY
CCCCCCCCCCCCHHH		31.0625168779
852PhosphorylationNRRDSNTSTISSAYL
CCCCCCCCCCCHHHH		28.1725168779
853PhosphorylationRRDSNTSTISSAYLS
CCCCCCCCCCHHHHH		23.8825168779
855PhosphorylationDSNTSTISSAYLSSR
CCCCCCCCHHHHHHC		14.7025168779
856PhosphorylationSNTSTISSAYLSSRR
CCCCCCCHHHHHHCC		19.6525168779
858PhosphorylationTSTISSAYLSSRRSS
CCCCCHHHHHHCCCC		14.7425168779
864PhosphorylationAYLSSRRSSGISPCF
HHHHHCCCCCCCCCC		31.6325619855
865PhosphorylationYLSSRRSSGISPCFS
HHHHCCCCCCCCCCC		38.0325619855
868PhosphorylationSRRSSGISPCFSSRR
HCCCCCCCCCCCCCC		21.0925619855
872PhosphorylationSGISPCFSSRRSSEA
CCCCCCCCCCCCHHH		29.6525619855
873PhosphorylationGISPCFSSRRSSEAS
CCCCCCCCCCCHHHH		16.0925619855
876PhosphorylationPCFSSRRSSEASQAE
CCCCCCCCHHHHHCC		31.2725338131
877PhosphorylationCFSSRRSSEASQAEG
CCCCCCCHHHHHCCC		35.0624453211
906PhosphorylationSTDASRRSSEASQGD
CCCHHHHHCCHHCCC		31.2726160508
907PhosphorylationTDASRRSSEASQGDG
CCHHHHHCCHHCCCC		35.0626160508
910PhosphorylationSRRSSEASQGDGLPS
HHHHCCHHCCCCCCC		30.5526160508
917PhosphorylationSQGDGLPSLLSLTPV
HCCCCCCCHHHCCHH		47.1626160508
920PhosphorylationDGLPSLLSLTPVQQY
CCCCCHHHCCHHHHH		35.1726160508
922PhosphorylationLPSLLSLTPVQQYRL
CCCHHHCCHHHHHHH		20.3125168779
927PhosphorylationSLTPVQQYRLKAKYA
HCCHHHHHHHHHHHH		10.7925168779
933PhosphorylationQYRLKAKYAAATGGP
HHHHHHHHHHHHCCC		13.3125168779
937PhosphorylationKAKYAAATGGPPPTP
HHHHHHHHCCCCCCC		37.6325168779
943PhosphorylationATGGPPPTPLPHMER
HHCCCCCCCCCHHHH		43.1425168779
952PhosphorylationLPHMERLSLKTKMAL
CCHHHHHCHHHHHHH		33.7625168779
955PhosphorylationMERLSLKTKMALLGE
HHHHCHHHHHHHHCC		31.2025168779
980PhosphorylationVHPPRRCSDGGGHTY
CCCCCCCCCCCCCCC		37.1629899451
1006PhosphorylationANSVRRASDPVRTVS
HHHHHHCCCCCCCCC		40.4129899451
1013PhosphorylationSDPVRTVSENMSLAR
CCCCCCCCCCCCHHH		23.7328066266
1017PhosphorylationRTVSENMSLARVQRF
CCCCCCCCHHHHHHH		30.3828066266
1029PhosphorylationQRFSSLNSFNPPNLP
HHHHCCCCCCCCCCC		31.52-
1259PhosphorylationFKTQQYGSQLNRQPL
CCHHHCCCCCCCCCC		26.9328066266
1523PhosphorylationGDHTSLMSGALSPSI
CCCHHHHCCCCCHHH		26.63-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
849SPhosphorylationKinasePKA-Uniprot
865SPhosphorylationKinasePKA-Uniprot
877SPhosphorylationKinasePKA-Uniprot
907SPhosphorylationKinasePKA-Uniprot
980SPhosphorylationKinasePKA-Uniprot
1006SPhosphorylationKinasePKA-Uniprot
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GLI3_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GLI3_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TWST1_MOUSETwist1genetic
12142027
SPOP_MOUSESpopphysical
20463034
SUFU_MOUSESufuphysical
20463034
SMO_MOUSESmogenetic
12435628
ZIC3_MOUSEZic3genetic
22234993
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GLI3_MOUSE

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Related Literatures of Post-Translational Modification

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