TWST1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TWST1_MOUSE
• UniProt AC: P26687
• Protein Name: Twist-related protein 1
• Gene Name: Twist1
• Organism: Mus musculus (Mouse).
• Sequence Length: 206
• Subcellular Localization: Nucleus.
• Protein Description: Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-ARNTL/BMAL1 heterodimer..
• Protein Sequence: MMQDVSSSPVSPADDSLSNSEEEPDRQQPASGKRGARKRRSSRRSAGGSAGPGGATGGGIGGGDEPGSPAQGKRGKKSAGGGGGGGAGGGGGGGGGSSSGGGSPQSYEELQTQRVMANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDELDSKMASCSYVAHERLSYAFSVWRMEGAWSMSASH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MMQDVSSSPVSPADD CCCCCCCCCCCCCCC	23.09	25338131
11	Phosphorylation	DVSSSPVSPADDSLS CCCCCCCCCCCCCCC	20.11	25338131
18	Phosphorylation	SPADDSLSNSEEEPD CCCCCCCCCCCCCCC	42.11	25338131
20	Phosphorylation	ADDSLSNSEEEPDRQ CCCCCCCCCCCCCCC	42.90	25338131
34	Methylation	QQPASGKRGARKRRS CCCCCCHHHHHHHHH	47.75	81418805
41	Phosphorylation	RGARKRRSSRRSAGG HHHHHHHHCCCCCCC	32.03	25338131
42	Phosphorylation	GARKRRSSRRSAGGS HHHHHHHCCCCCCCC	29.87	20400976
45	Phosphorylation	KRRSSRRSAGGSAGP HHHHCCCCCCCCCCC	30.10	25619855
49	Phosphorylation	SRRSAGGSAGPGGAT CCCCCCCCCCCCCCC	29.18	25619855
56	Phosphorylation	SAGPGGATGGGIGGG CCCCCCCCCCCCCCC	39.37	25619855
68	Phosphorylation	GGGDEPGSPAQGKRG CCCCCCCCCCCCCCC	27.98	25619855
78	Phosphorylation	QGKRGKKSAGGGGGG CCCCCCCCCCCCCCC	35.31	-
98	Phosphorylation	GGGGGGSSSGGGSPQ CCCCCCCCCCCCCCC	35.96	26160508
99	Phosphorylation	GGGGGSSSGGGSPQS CCCCCCCCCCCCCCC	43.06	26160508
103	Phosphorylation	GSSSGGGSPQSYEEL CCCCCCCCCCCHHHH	24.04	26160508
106	Phosphorylation	SGGGSPQSYEELQTQ CCCCCCCCHHHHHHH	37.58	26160508
107	Phosphorylation	GGGSPQSYEELQTQR CCCCCCCHHHHHHHH	14.26	26160508
112	Phosphorylation	QSYEELQTQRVMANV CCHHHHHHHHHHHHH	30.85	-
125	Phosphorylation	NVRERQRTQSLNEAF HHHHHHHHHHHHHHH	17.74	-
127	Phosphorylation	RERQRTQSLNEAFAA HHHHHHHHHHHHHHH	32.33	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TWST1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TWST1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TWST1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ESPB1_HUMAN	ELSPBP1	physical	19950203
P53_MOUSE	Trp53	physical	22975381

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.