SMO_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SMO_MOUSE
• UniProt AC: P56726
• Protein Name: Smoothened homolog
• Gene Name: Smo
• Organism: Mus musculus (Mouse).
• Sequence Length: 793
• Subcellular Localization: Membrane; Multi-pass membrane protein. Cell projection, cilium .
• Protein Description: G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO) (By similarity). Required for the accumulation of KIF7, GLI2 and GLI3 in the cilia. Interacts with DLG5 at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation. [PubMed: 25644602]
• Protein Sequence: MAAGRPVRGPELAPRRLLQLLLLVLLGGPGRGAALSGNVTGPGPHSASGSSRRDVPVTSPPPPLLSHCGRAAHCEPLRYNVCLGSALPYGATTTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWAVIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDHFPEGCPNEVQNIKFNSSGQCEAPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRADGTMRFGEPTSSETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLCQANVTIGLPTKKPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRTWCRLTGHSDDEPKRIKKSKMIAKAFSKRRELLQNPGQELSFSMHTVSHDGPVAGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDVSVTPVATPVPPEEQANMWLVEAEISPELEKRLGRKKKRRKRKKEVCPLRPAPELHHSAPVPATSAVPRLPQLPRQKCLVAANAWGTGESCRQGAWTLVSNPFCPEPSPHQDPFLPGASAPRVWAQGRLQGLGSIHSRTNLMEAEILDADSDF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
38	N-linked_Glycosylation	RGAALSGNVTGPGPH CCCHHCCCCCCCCCC	25.46	-
40	Phosphorylation	AALSGNVTGPGPHSA CHHCCCCCCCCCCCC	41.48	-
48	Phosphorylation	GPGPHSASGSSRRDV CCCCCCCCCCCCCCC	42.07	-
50	Phosphorylation	GPHSASGSSRRDVPV CCCCCCCCCCCCCCC	20.41	-
51	Phosphorylation	PHSASGSSRRDVPVT CCCCCCCCCCCCCCC	34.56	-
192	N-linked_Glycosylation	EVQNIKFNSSGQCEA CCEEEEECCCCCEEC	30.20	-
497	N-linked_Glycosylation	DYVLCQANVTIGLPT HHEEEEEEEEECCCC	12.94	-
518	Phosphorylation	CEIKNRPSLLVEKIN CCCCCCHHHHHHHHH	30.97	21189417
774	Phosphorylation	GRLQGLGSIHSRTNL CCCCCCCCCCCCCCC	23.36	26824392
777	Phosphorylation	QGLGSIHSRTNLMEA CCCCCCCCCCCCEEE	38.85	26824392
791	Phosphorylation	AEILDADSDF----- EEECCCCCCC-----	42.51	25619855

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SMO_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SMO_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SMO_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CATC_HUMAN	CTSC	physical	26496610
AP2S1_HUMAN	AP2S1	physical	26496610
PDE4D_HUMAN	PDE4D	physical	26496610
RL10_HUMAN	RPL10	physical	26496610
MOGS_HUMAN	MOGS	physical	26496610
TLK2_HUMAN	TLK2	physical	26496610
CE164_HUMAN	CEP164	physical	26496610
PANX1_HUMAN	PANX1	physical	26496610
VPS4A_HUMAN	VPS4A	physical	26496610
ENY2_HUMAN	ENY2	physical	26496610
DERL1_HUMAN	DERL1	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.