ENY2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ENY2_HUMAN
• UniProt AC: Q9NPA8
• Protein Name: Transcription and mRNA export factor ENY2 {ECO:0000255|HAMAP-Rule:MF_03046}
• Gene Name: ENY2 {ECO:0000255|HAMAP-Rule:MF_03046}
• Organism: Homo sapiens (Human).
• Sequence Length: 101
• Subcellular Localization: Nucleus, nucleoplasm . Nucleus, nuclear pore complex .
• Protein Description: Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery..
• Protein Sequence: MVVSKMNKDAQMRAAINQKLIETGERERLKELLRAKLIECGWKDQLKAHCKEVIKEKGLEHVTVDDLVAEITPKGRALVPDSVKKELLQRIRTFLAQHASL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1 (in isoform 2)	Acetylation	-	6.40	22814378
4	Phosphorylation	----MVVSKMNKDAQ ----CCCCCCCHHHH	18.12	20068231
5	Acetylation	---MVVSKMNKDAQM ---CCCCCCCHHHHH	34.58	25953088
8	Acetylation	MVVSKMNKDAQMRAA CCCCCCCHHHHHHHH	51.44	25953088
8	Ubiquitination	MVVSKMNKDAQMRAA CCCCCCCHHHHHHHH	51.44	-
19	Ubiquitination	MRAAINQKLIETGER HHHHHHHHHHHHCHH	47.12	21890473
19	Acetylation	MRAAINQKLIETGER HHHHHHHHHHHHCHH	47.12	25953088
30	Ubiquitination	TGERERLKELLRAKL HCHHHHHHHHHHHHH	53.16	-
36	Ubiquitination	LKELLRAKLIECGWK HHHHHHHHHHHCCCH	43.49	-
36	Acetylation	LKELLRAKLIECGWK HHHHHHHHHHHCCCH	43.49	25953088
40	S-nitrosocysteine	LRAKLIECGWKDQLK HHHHHHHCCCHHHHH	6.63	-
40	Glutathionylation	LRAKLIECGWKDQLK HHHHHHHCCCHHHHH	6.63	22555962
40	S-nitrosylation	LRAKLIECGWKDQLK HHHHHHHCCCHHHHH	6.63	19483679
43	Ubiquitination	KLIECGWKDQLKAHC HHHHCCCHHHHHHHH	22.38	-
43	Acetylation	KLIECGWKDQLKAHC HHHHCCCHHHHHHHH	22.38	23954790
57	Ubiquitination	CKEVIKEKGLEHVTV HHHHHHHCCCCCCCH	64.89	-
72	Phosphorylation	DDLVAEITPKGRALV HHHHHHCCCCCCCCC	15.51	-
74	Ubiquitination	LVAEITPKGRALVPD HHHHCCCCCCCCCCH	52.99	21890473
74	Sumoylation	LVAEITPKGRALVPD HHHHCCCCCCCCCCH	52.99	28112733
82	Phosphorylation	GRALVPDSVKKELLQ CCCCCCHHHHHHHHH	29.75	20068231
84	2-Hydroxyisobutyrylation	ALVPDSVKKELLQRI CCCCHHHHHHHHHHH	44.47	-
85	Ubiquitination	LVPDSVKKELLQRIR CCCHHHHHHHHHHHH	51.98	-
100	Phosphorylation	TFLAQHASL------ HHHHHHHCC------	32.27	30108239

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ENY2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ENY2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ENY2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GANP_HUMAN	MCM3AP	physical	16169070
TRRAP_HUMAN	TRRAP	physical	18206972
KAT2A_HUMAN	KAT2A	physical	18206972
TAF10_HUMAN	TAF10	physical	18206972
UBP22_HUMAN	USP22	physical	18206972
AT7L3_HUMAN	ATXN7L3	physical	18206972
A4_HUMAN	APP	physical	21832049
H2AX_HUMAN	H2AFX	physical	26344197
A7L3B_HUMAN	ATXN7L3B	physical	27601583
AT7L3_HUMAN	ATXN7L3	physical	27601583

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.