A7L3B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: A7L3B_HUMAN
• UniProt AC: Q96GX2
• Protein Name: Ataxin-7-like protein 3B
• Gene Name: ATXN7L3B
• Organism: Homo sapiens (Human).
• Sequence Length: 97
• Subcellular Localization: Cytoplasm .
• Protein Description: By binding to ENY2, interferes with the nuclear functions of the deubiquitinase (DUB) module of the SAGA complex which consists of ENY2, ATXN7, ATXN7L3 and the histone deubiquitinating component USP22. Affects USP22 DUB activity toward histones indirectly by changing the subcellular distribution of ENY2 and altering ENY2 availability for ATXN7L3 interaction. Regulates H2B monoubiquitination (H2Bub1) levels through cytoplasmic sequestration of ENY2 resulting in loss of nuclear ENY2-ATXN7L3 association which destabilizes ATXN7L3. Affects protein expression levels of ENY2 and ATXN7L3..
• Protein Sequence: MEEISLANLDTNKLEAIAQEIYVDLIEDSCLGFCFEVHRAVKCGYFYLEFAETGSVKDFGIQPVEDKGACRLPLCSLPGEPGNGPDQQLQRSPPEFQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MEEISLANLDTN ---CCCEECCCCCHH	25.39	26074081
11	Phosphorylation	ISLANLDTNKLEAIA EECCCCCHHHHHHHH	37.10	26074081
45	Phosphorylation	HRAVKCGYFYLEFAE HHHHHCCEEEEEEEE	9.87	-
47	Phosphorylation	AVKCGYFYLEFAETG HHHCCEEEEEEEECC	9.24	-
67	Acetylation	GIQPVEDKGACRLPL CCCCCCCCCCEECEE	34.60	23749302
67	Ubiquitination	GIQPVEDKGACRLPL CCCCCCCCCCEECEE	34.60	33845483
76	Phosphorylation	ACRLPLCSLPGEPGN CEECEECCCCCCCCC	45.33	20068231
92	Phosphorylation	PDQQLQRSPPEFQ-- CCHHHHCCCCCCC--	31.67	23401153

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of A7L3B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of A7L3B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of A7L3B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ENY2_HUMAN	ENY2	physical	27601583
UBP22_HUMAN	USP22	physical	27601583
TAF6L_HUMAN	TAF6L	physical	27601583
TAF10_HUMAN	TAF10	physical	27601583
TADA3_HUMAN	TADA3	physical	27601583

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.