GLI1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GLI1_MOUSE
• UniProt AC: P47806
• Protein Name: Zinc finger protein GLI1
• Gene Name: Gli1
• Organism: Mus musculus (Mouse).
• Sequence Length: 1111
• Subcellular Localization: Cytoplasm . Nucleus . Tethered in the cytoplasm by binding to SUFU. Activation and translocation to the nucleus is promoted by interaction with STK36. Phosphorylation by ULK3 may promote nuclear localization. Translocation to the nucleus is promoted
• Protein Description: Acts as a transcriptional activator. Binds to the DNA consensus sequence 5'-GACCACCCA-3'. May regulate the transcription of specific genes during normal development. May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling. Plays a role in cell proliferation and differentiation via its role in SHH signaling..
• Protein Sequence: MFNPMTPPQVNSYSEPCCLRPLHSQGVPSMGTEGLSGLPFCHQANFMSGSQGYGAARETSSCTEGSLFPPPPPPRSSVKLTKKRALSISPLSDASLDLQTVIRTSPSSLVAFINSRCTSPGGSYGHLSIGTMSPSLGFPPQMSHQKGTSPPYGVQPCVPHDSTRGSMMLHPQSRGPRATCQLKSELDMMVGKCPEDPLEGDMSSPNSTGTQDHLLGMLDGREDLEREEKPEPESVYETDCRWDGCSQEFDSQEQLVHHINSEHIHGERKEFVCHWGGCSRELRPFKAQYMLVVHMRRHTGEKPHKCTFEGCRKSYSRLENLKTHLRSHTGEKPYMCEQEGCSKAFSNASDRAKHQNRTHSNEKPYVCKLPGCTKRYTDPSSLRKHVKTVHGPDAHVTKRHRGDGPLPRAQPLSTVEPKREREGGSGREESRLTVPESAMPQQSPGAQSSCSSDHSPAGSAANTDSGVEMAGNAGGSTEDLSSLDEGPCVSATGLSTLRRLENLRLDQLHQLRPIGSRGLKLPSLTHAGAPVSRRLGPPVSLDRRSSSSSSMSSAYTVSRRSSLASPFPPGTPPENGASSLPGLTPAQHYMLRARYASARGSGTPPTAAHSLDRMGGLSVPPWRSRTEYPGYNPNAGVTRRASDPARAADHPAPARVQRFKSLGCVHTPPSVATGRNFDPHHPTSVYSPQPPSITENVAMDTRGLQEEPEVGTSVMGNGLNPYMDFSSTDTLGYGGPEGTAAEPYEARGPGSLPLGPGPPTNYGPGHCAQQVSYPDPTPENWGEFPSHAGVYPSNKAPGAAYSQCPRLEHYGQVQVKPEQGCPVGSDSTGLAPCLNAHPSEGSPGPQPLFSHHPQLPQPQYPQSGPYPQPPHGYLSTEPRLGLNFNPSSSHSTGQLKAQLVCNYVQSQQELLWEGRNRGGLPNQELPYQSPKFLGGSQVSQSPAKTPAAAAAAYGSGFAPASANHKSGSYPAPSPCHETFTVGVNRPSHRPAAPPRLLPPLSPCYGPLKVGDTNPSCGHPEVGRLGAGPALYPPPEGQVCNALDSLDLDNTQLDFVAILDEAQGLSPPLSHEQGDSSKNTPSPSGPPNMAVGNMSVLLGSLPGETQFLNSSA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
79	Phosphoglycerylation	PPPRSSVKLTKKRAL CCCCCCCCCCCCCEE	53.00	-
92	Phosphorylation	ALSISPLSDASLDLQ EECCCCCCCCCCCHH	34.22	26643407
95	Phosphorylation	ISPLSDASLDLQTVI CCCCCCCCCCHHHHH	27.66	26643407
100	Phosphorylation	DASLDLQTVIRTSPS CCCCCHHHHHCCCHH	25.79	26643407
104	Phosphorylation	DLQTVIRTSPSSLVA CHHHHHCCCHHHHHH	33.59	22006019
135	Phosphorylation	SIGTMSPSLGFPPQM EEECCCHHHCCCCCC	33.54	-
323	Phosphorylation	SRLENLKTHLRSHTG HHHHHHHHHHHHHCC	29.34	-
413	Phosphorylation	LPRAQPLSTVEPKRE CCCCCCCCCCCCCCC	36.77	23984901
414	Phosphorylation	PRAQPLSTVEPKRER CCCCCCCCCCCCCCC	36.25	23984901
520	Acetylation	PIGSRGLKLPSLTHA CCCCCCCCCCCCCCC	62.26	62154801
929	Phosphorylation	NQELPYQSPKFLGGS CCCCCCCCCCCCCCC	24.98	22006019
941	Phosphorylation	GGSQVSQSPAKTPAA CCCCCCCCCCCCHHH	21.22	22006019
1001	Phosphorylation	PRLLPPLSPCYGPLK CCCCCCCCCCCCCCC	20.78	22006019
1081	Phosphorylation	DSSKNTPSPSGPPNM CCCCCCCCCCCCCCC	29.65	22006019
1083	Phosphorylation	SKNTPSPSGPPNMAV CCCCCCCCCCCCCEE	69.17	22006019

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
481	S	Phosphorylation	Kinase	PLK1	P53350	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
520	K	Acetylation	Acetylation at Lys-520 down-regulates transcriptional activity.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GLI1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SUFU_MOUSE	Sufu	physical	21076395
SNF5_MOUSE	Smarcb1	physical	21076395
SMRC2_MOUSE	Smarcc2	physical	21076395
SMCE1_MOUSE	Smarce1	physical	21076395
SUFU_MOUSE	Sufu	physical	10531011

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.