PRDX5_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PRDX5_MOUSE
• UniProt AC: P99029
• Protein Name: Peroxiredoxin-5, mitochondrial
• Gene Name: Prdx5
• Organism: Mus musculus (Mouse).
• Sequence Length: 210
• Subcellular Localization: Isoform Mitochondrial: Mitochondrion .; Isoform Cytoplasmic+peroxisomal: Cytoplasm . Peroxisome matrix .
• Protein Description: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events..
• Protein Sequence: MLQLGLRVLGCKASSVLRASTCLAGRAGRKEAGWECGGARSFSSSAVTMAPIKVGDAIPSVEVFEGEPGKKVNLAELFKGKKGVLFGVPGAFTPGCSKTHLPGFVEQAGALKAKGAQVVACLSVNDVFVIEEWGRAHQAEGKVRLLADPTGAFGKATDLLLDDSLVSLFGNRRLKRFSMVIDNGIVKALNVEPDGTGLTCSLAPNILSQL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12 (in isoform 2)	Phosphorylation	-	49.89	30352176
22 (in isoform 2)	Acetylation	-	1.96	-
31 (in isoform 2)	Acetylation	-	51.56	-
44	Phosphorylation	GGARSFSSSAVTMAP CCCCCCCCCCEEECC	21.95	28059163
45	Phosphorylation	GARSFSSSAVTMAPI CCCCCCCCCEEECCE	26.09	28059163
53	Acetylation	AVTMAPIKVGDAIPS CEEECCEECCCCCCE	38.82	23576753
53	Malonylation	AVTMAPIKVGDAIPS CEEECCEECCCCCCE	38.82	26320211
64 (in isoform 2)	Acetylation	-	6.72	-
70	Succinylation	VFEGEPGKKVNLAEL EECCCCCCEEEHHHH	65.35	-
70	Succinylation	VFEGEPGKKVNLAEL EECCCCCCEEEHHHH	65.35	23806337
70	Malonylation	VFEGEPGKKVNLAEL EECCCCCCEEEHHHH	65.35	26320211
70	Ubiquitination	VFEGEPGKKVNLAEL EECCCCCCEEEHHHH	65.35	27667366
70	Acetylation	VFEGEPGKKVNLAEL EECCCCCCEEEHHHH	65.35	23576753
71	Ubiquitination	FEGEPGKKVNLAELF ECCCCCCEEEHHHHH	42.12	27667366
71	Acetylation	FEGEPGKKVNLAELF ECCCCCCEEEHHHHH	42.12	23576753
71	Succinylation	FEGEPGKKVNLAELF ECCCCCCEEEHHHHH	42.12	26388266
79	Acetylation	VNLAELFKGKKGVLF EEHHHHHCCCCEEEE	80.56	23576753
79	Succinylation	VNLAELFKGKKGVLF EEHHHHHCCCCEEEE	80.56	23806337
79	Succinylation	VNLAELFKGKKGVLF EEHHHHHCCCCEEEE	80.56	-
79	Ubiquitination	VNLAELFKGKKGVLF EEHHHHHCCCCEEEE	80.56	-
81	Succinylation	LAELFKGKKGVLFGV HHHHHCCCCEEEEEC	47.12	26388266
81	Acetylation	LAELFKGKKGVLFGV HHHHHCCCCEEEEEC	47.12	24062335
82	Acetylation	AELFKGKKGVLFGVP HHHHCCCCEEEEECC	64.02	24062335
93	Phosphorylation	FGVPGAFTPGCSKTH EECCCCCCCCCCCCC	20.45	22817900
94 (in isoform 2)	Acetylation	-	35.03	-
96	S-palmitoylation	PGAFTPGCSKTHLPG CCCCCCCCCCCCCCC	3.87	28526873
96	Glutathionylation	PGAFTPGCSKTHLPG CCCCCCCCCCCCCCC	3.87	24333276
96	S-nitrosocysteine	PGAFTPGCSKTHLPG CCCCCCCCCCCCCCC	3.87	-
96	S-nitrosylation	PGAFTPGCSKTHLPG CCCCCCCCCCCCCCC	3.87	24895380
97	Phosphorylation	GAFTPGCSKTHLPGF CCCCCCCCCCCCCCH	46.64	29472430
98	Ubiquitination	AFTPGCSKTHLPGFV CCCCCCCCCCCCCHH	44.00	-
98	Acetylation	AFTPGCSKTHLPGFV CCCCCCCCCCCCCHH	44.00	23806337
98	Succinylation	AFTPGCSKTHLPGFV CCCCCCCCCCCCCHH	44.00	23806337
112	Malonylation	VEQAGALKAKGAQVV HHHHCCCCCCCCEEE	47.74	26320211
112	Succinylation	VEQAGALKAKGAQVV HHHHCCCCCCCCEEE	47.74	23806337
112	Succinylation	VEQAGALKAKGAQVV HHHHCCCCCCCCEEE	47.74	-
112	Acetylation	VEQAGALKAKGAQVV HHHHCCCCCCCCEEE	47.74	23864654
112	Ubiquitination	VEQAGALKAKGAQVV HHHHCCCCCCCCEEE	47.74	-
142	Acetylation	RAHQAEGKVRLLADP HHHCCCCCEEEEECC	18.71	23806337
142	Succinylation	RAHQAEGKVRLLADP HHHCCCCCEEEEECC	18.71	23806337
155	Acetylation	DPTGAFGKATDLLLD CCCCCCCHHHHHHHC	41.48	24062335
155	Succinylation	DPTGAFGKATDLLLD CCCCCCCHHHHHHHC	41.48	26388266
164	Phosphorylation	TDLLLDDSLVSLFGN HHHHHCHHHHHHHCC	30.27	21183079
167	Phosphorylation	LLDDSLVSLFGNRRL HHCHHHHHHHCCCCH	24.23	22324799
178	Phosphorylation	NRRLKRFSMVIDNGI CCCHHHEEEEEECCC	19.03	26239621
200	S-nitrosocysteine	PDGTGLTCSLAPNIL CCCCCEEEECCHHHH	3.64	-
200	S-nitrosylation	PDGTGLTCSLAPNIL CCCCCEEEECCHHHH	3.64	24895380
201	Phosphorylation	DGTGLTCSLAPNILS CCCCEEEECCHHHHH	23.49	24719451
208	Phosphorylation	SLAPNILSQL----- ECCHHHHHCC-----	26.16	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PRDX5_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PRDX5_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PRDX5_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PRDX5_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.