RN19A_MOUSE - dbPTM
RN19A_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RN19A_MOUSE
UniProt AC P50636
Protein Name E3 ubiquitin-protein ligase RNF19A
Gene Name Rnf19a
Organism Mus musculus (Mouse).
Sequence Length 840
Subcellular Localization Membrane
Multi-pass membrane protein . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Expressed primarily in the XY body of pachytene spermatocytes and in the centrosome of somatic and germ cells in all phases of the cell cycl
Protein Description E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR..
Protein Sequence MQEQEISFIFKYNEGLCMNIDSDSILMSILDMSLHQQMGSDRDLQSSTSSVSLPSVKKAPKQRRISIGSLFRRKKDSKRKSRELNGGVDGIASIESIHSEMCADKNSIFSTNTSSDNGLTSISKQIGDFIECPLCLLRHSKDRFPDIMTCHHRSCVDCLRQYLRIEISESRVNISCPECTERFNPHDIRLILSDDVLMEKYEEFMLRRWLVADPDCRWCPAPDCGYAVIAFGCASCPKLTCGREGCGTEFCYHCKQIWHPNQTCDAARQERAQSLRLRTIRSSSISYSQESGAAADDIKPCPRCAAYIIKMNDGSCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKILWQLGTLVGAPVGIALIAGIAIPAMIIGIPVYVGRKIHNRYEGKDVSKHKRNLAIAGGVTLSVIVSPVVAAVTVGIGVPIMLAYVYGVVPISLCRSGGCGVSAGNGKGVRIEFDDENDINVGGTNAAIDTTSVAEARHNPSIGEGSVGGLTGSLSASGSHMDRIGTIRDNLSETASTMALAGASITGSLSGSAMVNCFNRLEVQADVQKERCSLSGESGTVSLGTVSDNASTKAMAGSILNSYIPLDREGNSMEVQVDIESKPFKFRHNSGSSSVDDSGATRGHTGGASSGLPEGKSSATKWSKEATGGKKSKSGKLRKKGNMKINETREDMDAQLLEQQSTNSSEFEAPSLSDSMPSVADSHSSHFSEFSCSDLESMRTSCSHGSSDCHARFTAVNTLPEVENDRLENSPHQCSSALLSKAASCSDVPQPSHAADEHGTSRSGGKPMVDLCFGDALRETNNNHSHQTADLKVAVQTEI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
46PhosphorylationGSDRDLQSSTSSVSL
CCCCCHHCCCCCCCC		42.7722817900
66PhosphorylationAPKQRRISIGSLFRR
CCCCCCCCHHHHHHC		21.0522942356
69PhosphorylationQRRISIGSLFRRKKD
CCCCCHHHHHHCCCC		23.7528833060
282PhosphorylationLRLRTIRSSSISYSQ
HCHHHHHHHCCCCCC		25.2925619855
283PhosphorylationRLRTIRSSSISYSQE
CHHHHHHHCCCCCCC		23.1125619855
284PhosphorylationLRTIRSSSISYSQES
HHHHHHHCCCCCCCC		19.4625619855
286PhosphorylationTIRSSSISYSQESGA
HHHHHCCCCCCCCCC		22.2225619855
288PhosphorylationRSSSISYSQESGAAA
HHHCCCCCCCCCCCC		22.2325619855
291PhosphorylationSISYSQESGAAADDI
CCCCCCCCCCCCCCC		26.5425619855
493PhosphorylationNAAIDTTSVAEARHN
CCCEECCCHHHHHCC		22.7925338131
502PhosphorylationAEARHNPSIGEGSVG
HHHHCCCCCCCCCCC		48.8425619855
507PhosphorylationNPSIGEGSVGGLTGS
CCCCCCCCCCHHHCE		17.1825619855
512PhosphorylationEGSVGGLTGSLSASG
CCCCCHHHCEEECCC		28.1825619855
514PhosphorylationSVGGLTGSLSASGSH
CCCHHHCEEECCCCC		17.5725619855
516PhosphorylationGGLTGSLSASGSHMD
CHHHCEEECCCCCHH		23.3025619855
518PhosphorylationLTGSLSASGSHMDRI
HHCEEECCCCCHHHH		37.1425619855
520PhosphorylationGSLSASGSHMDRIGT
CEEECCCCCHHHHEE		17.0925619855
574PhosphorylationDVQKERCSLSGESGT
EHHHHCEECCCCCCE		31.6229514104
599PhosphorylationSTKAMAGSILNSYIP
CCHHHHHHHHHCCCC		17.8622006019
631PhosphorylationPFKFRHNSGSSSVDD
CEEEECCCCCCCCCC		33.6530352176
633PhosphorylationKFRHNSGSSSVDDSG
EEECCCCCCCCCCCC		21.1826643407
634PhosphorylationFRHNSGSSSVDDSGA
EECCCCCCCCCCCCC		37.6026824392
635PhosphorylationRHNSGSSSVDDSGAT
ECCCCCCCCCCCCCC		31.1228066266
671AcetylationSKEATGGKKSKSGKL
CHHHHCCCCCCCCCC		56.046568405
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RN19A_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RN19A_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RN19A_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SUFU_MOUSESufuphysical
14611647
PIAS1_MOUSEPias1physical
14611647
TERA_MOUSEVcpphysical
15456787
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RN19A_MOUSE

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Related Literatures of Post-Translational Modification

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