dbPTM

RBM39_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RBM39_MOUSE
UniProt AC	Q8VH51
Protein Name	RNA-binding protein 39
Gene Name	Rbm39
Organism	Mus musculus (Mouse).
Sequence Length	530
Subcellular Localization	Nucleus .
Protein Description	Transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1. May be involved in pre-mRNA splicing process..
Protein Sequence	MADDIDIEAMLEAPYKKDENKLNSANGHEERSKKRKKSKSRSRSHERKRSKSKERKRSRDRERKKSKSRERKRSRSKERRRSRSRSRDRRFRGRYRSPYSGPKFNSAIRGKIGLPHSIKLSRRRSRSKSPFRKDKSPVREPIDNLTPEERDARTVFCMQLAARIRPRDLEEFFSTVGKVRDVRMISDRNSRRSKGIAYVEFVDVSSVPLAIGLTGQRVLGVPIIVQASQAEKNRAAAMANNLQKGSAGPMRLYVGSLHFNITEDMLRGIFEPFGRIESIQLMMDSETGRSKGYGFITFSDSECAKKALEQLNGFELAGRPMKVGHVTERTDASSASSFLDSDELERTGIDLGTTGRLQLMARLAEGTGLQIPPAAQQALQMSGSLAFGAVAEFSFVIDLQTRLSQQTEASALAAAASVQPLATQCFQLSNMFNPQTEEEVGWDTEIKDDVIEECNKHGGVIHIYVDKNSAQGNVYVKCPSIAAAIAAVNALHGRWFAGKMITAAYVPLPTYHNLFPDSMTATQLLVPSRR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MADDIDIEA ------CCCCCCHHH	24.15	-
24	Phosphorylation	KDENKLNSANGHEER CCCCCCCCCCCCHHH	33.28	27841257
40	Phosphorylation	KKRKKSKSRSRSHER HHHHHHHHHHHHHHH	42.45	19367708
42	Phosphorylation	RKKSKSRSRSHERKR HHHHHHHHHHHHHHH	45.27	19367708
44	Phosphorylation	KSKSRSRSHERKRSK HHHHHHHHHHHHHHH	30.83	19367708
95	Phosphorylation	DRRFRGRYRSPYSGP HHHHHCCCCCCCCCC	20.47	27087446
97	Phosphorylation	RFRGRYRSPYSGPKF HHHCCCCCCCCCCCH	21.18	27087446
99	Phosphorylation	RGRYRSPYSGPKFNS HCCCCCCCCCCCHHH	27.75	23984901
100	Phosphorylation	GRYRSPYSGPKFNSA CCCCCCCCCCCHHHH	52.59	25521595
106	Phosphorylation	YSGPKFNSAIRGKIG CCCCCHHHHHHCCCC	28.36	29514104
109	Methylation	PKFNSAIRGKIGLPH CCHHHHHHCCCCCCC	39.82	12019205
117	Phosphorylation	GKIGLPHSIKLSRRR CCCCCCCCHHHHCCC	21.34	26824392
121	Phosphorylation	LPHSIKLSRRRSRSK CCCCHHHHCCCCCCC	20.81	26824392
125	Phosphorylation	IKLSRRRSRSKSPFR HHHHCCCCCCCCCCC	38.81	23684622
127	Phosphorylation	LSRRRSRSKSPFRKD HHCCCCCCCCCCCCC	38.44	23684622
129	Phosphorylation	RRRSRSKSPFRKDKS CCCCCCCCCCCCCCC	30.43	23684622
136	Phosphorylation	SPFRKDKSPVREPID CCCCCCCCCCCCCCC	38.47	24925903
146	Phosphorylation	REPIDNLTPEERDAR CCCCCCCCHHHHHHH	34.60	24925903
174	Phosphorylation	RDLEEFFSTVGKVRD CCHHHHHHHCCCHHE	27.75	29550500
175	Phosphorylation	DLEEFFSTVGKVRDV CHHHHHHHCCCHHEE	28.28	29550500
178	Ubiquitination	EFFSTVGKVRDVRMI HHHHHCCCHHEEEEE	29.75	22790023
232	Ubiquitination	VQASQAEKNRAAAMA EECHHHHHHHHHHHH	55.54	22790023
306	Ubiquitination	SDSECAKKALEQLNG CCHHHHHHHHHHCCC	39.41	22790023
330	Phosphorylation	VGHVTERTDASSASS CCCCEECCCCCHHHH	29.68	25619855
333	Phosphorylation	VTERTDASSASSFLD CEECCCCCHHHHHCC	29.28	25619855
334	Phosphorylation	TERTDASSASSFLDS EECCCCCHHHHHCCH	33.61	22942356
336	Phosphorylation	RTDASSASSFLDSDE CCCCCHHHHHCCHHH	24.46	25521595
337	Phosphorylation	TDASSASSFLDSDEL CCCCHHHHHCCHHHH	29.55	25521595
341	Phosphorylation	SASSFLDSDELERTG HHHHHCCHHHHHHHC	34.82	27149854
347	Phosphorylation	DSDELERTGIDLGTT CHHHHHHHCCCCCHH	29.16	19854140
353	Phosphorylation	RTGIDLGTTGRLQLM HHCCCCCHHHHHHHH	33.12	22942356
354	Phosphorylation	TGIDLGTTGRLQLMA HCCCCCHHHHHHHHH	20.64	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RBM39_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RBM39_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RBM39_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
NCOA6_HUMAN	NCOA6	physical	11704680

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RBM39_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry."; Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.; Mol. Cell. Proteomics 8:904-912(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-97 AND SER-136, AND MASSSPECTROMETRY.	19131326 [Abstract]
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-97 AND SER-136, AND MASSSPECTROMETRY.	19367708 [Abstract]
"Comprehensive identification of phosphorylation sites in postsynapticdensity preparations."; Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,Burlingame A.L.; Mol. Cell. Proteomics 5:914-922(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-136, AND MASSSPECTROMETRY.	16452087 [Abstract]
"Identification of phosphoproteins and their phosphorylation sites inthe WEHI-231 B lymphoma cell line."; Shu H., Chen S., Bi Q., Mumby M., Brekken D.L.; Mol. Cell. Proteomics 3:279-286(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-136 AND SER-337, ANDMASS SPECTROMETRY.	14729942 [Abstract]