INT13_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: INT13_MOUSE
• UniProt AC: Q8QZV7
• Protein Name: Integrator complex subunit 13 {ECO:0000312|MGI:MGI:1918427}
• Gene Name: IntS13 {ECO:0000312|MGI:MGI:1918427}
• Organism: Mus musculus (Mouse).
• Sequence Length: 732
• Subcellular Localization: Nucleus . Cytoplasm . Nuclear location is required for recruitment of dynein motors to nuclear envelope at G2/M.
• Protein Description: Crucial regulator of the mitotic cell cycle and development. At prophase, required for dynein anchoring to the nuclear envelope important for proper centrosome-nucleus coupling. At G2/M phase, may be required for proper spindle formation and execution of cytokinesis. Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing..
• Protein Sequence: MKIFSESHKTVFVVDHCPYMAESCRQHVEFDMLVKNRTQGIIPLAPISKSLWTCSVESSMEYCRIMYDIFPFKKLVNFIVSDSGAHVLNSWTQEDQNLQELMAALATVGPPNPRADPECCSILHGLVAAVETLCKITEYQHEARTLLMENAERVGNRGRIICITNAKSDSHVRMLEDCVQETIHEHNKLAANSDHLMQIQKCELVLIHTYPVGEDSLVSDRPKKELSPVLTSEVHSVRAGRHLATKLNVLVQQHFDLASTTITNIPMKEEQHANTSANYDVELLHHKDAHVDFLRSGDSHSGSSSREGPFKETVTLKWCTPRTNSIELHYCTGAYRISPVDVNSRPSSCLTNFLLNGRSVLLEQPRKSGSKVISHMLSSHGGEIFLHVLSSSRSILEDPPSISEGCGGRVTDYRITDFGEFMRENRLTPFLDPRYKIDASLEIPLERAKDQLEKHTRYWPMIISQTTIFNMQAVVPLAGVIVKESLTEEDVLNCQKTIYNLVDMERKNDPLPVSTVGTRGKGPKRDEQYRIMWNELETLVRAHISNSEKHQRVLECLMACRSKPPEEEERKKRGRKREDREDKSEQAGKEHGTEKARPDADRLKGILERGKEELAEAEVIKDSPDSPEPPNKKPLVETDETPHMEKSKGPVSLLSLWSNRINTANSRKHQEFAGRLNSVNNRAELYQHLKEENGEEVGLTGGPRTAIPFLKCPRSPVVNRMETTENGKASRQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
368	Phosphorylation	LLEQPRKSGSKVISH EEECCCCCCCHHHHH		24719451
370	Phosphorylation	EQPRKSGSKVISHML ECCCCCCCHHHHHHH		25338131
623	Phosphorylation	EAEVIKDSPDSPEPP HCEECCCCCCCCCCC		28973931
626	Phosphorylation	VIKDSPDSPEPPNKK ECCCCCCCCCCCCCC		25521595
678	Phosphorylation	EFAGRLNSVNNRAEL HHHHHHHHHCCHHHH		24719451
715	Phosphorylation	PFLKCPRSPVVNRME CCCCCCCCCCCCCEE		25266776

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of INT13_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of INT13_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of INT13_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of INT13_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.