dbPTM

INT7_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	INT7_MOUSE
UniProt AC	Q7TQK1
Protein Name	Integrator complex subunit 7
Gene Name	Ints7
Organism	Mus musculus (Mouse).
Sequence Length	966
Subcellular Localization	Nucleus . Chromosome . Cytoplasm . Localizes to sites of DNA damage in a H2AX-independent manner.
Protein Description	Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Plays a role in DNA damage response (DDR) signaling during the S phase. May be not involved in the recruitment of cytoplasmic dynein to the nuclear envelope by different components of the INT complex..
Protein Sequence	MASNSTKSFLADAGYGEQELDANSALMELDKGLRSGKLGEQCEAVVRFPRLFQKYPFPILINSAFLKLADVFRVGNNFLRLCVLKVTQQSEKHLEKILNVDEFVKRVFSVIHSNDPVARAITLRMLGSLASIIPERKNAHHSIRQSLDSHDNVEVEAAVFAAANFSAQSKDFAVGICNKISEMIQGLATPVDLKLKLIPILQHMHHDALLASSARQLLQQLVTSYPSTKMVIVSLHTFTLLAASSLVDTPKQIQLLLQYLKNDPRKAVKRLAVQDLKLLASKTPHTWSKENIQALCECALHTPYDSLKLGMLSVLSTLSGTIAIKHYFSVVPGNVGSSPRSSDLVKLAQECCYHSNRGIAAHGVRVLTNITVSCQEKDLLSLEQDAVFGLESLLVLCSQDDSPGAQSTVKSALSCMVKLAKGRPHLSRSVVDTLLTQLHSSQDAARILMCHCLAAIAMQLPVLGDGMLGDLVELYKVIGRSATDKQQELLVSLATVIFVASQKALSAEVKAVIKQQLESVSSGWTVYRIARQASRMGNHDMARELYQSLLTQVASEHFYFWLNSLKEFSHAEQCLTGLQEDSFSSALSCIAESLKFYHKGIASLTAASTPLNPLSFQCEFVKLRIDLLQAFSQLICTCNSLKTSPPPAIATTIAMTLGNDLQRCGRISNQMKQSMEEFRSLASRYRDLYQASFDADSATLRNVELQQQSCLLIAHAIEALVLDPESASFQEYGSTGAAHADSEYERRMMSVYSRVLEEVESLNRKYAPVSYMHTACLCNAIIALLKVPLSFQRYFFQKLQSTSIKLALSPSPRSPAEPIAVQNNQQLALKVEGVVQHGSKPGLFRRVQSVCLNVSSTLQSKSGQDYKIPIDSMTNEMEQRVEPHNDYFSTQFLLNFAVLGTHSITVESSVRDANGIVWKTGPRTTMFVKSLEDPYSQQIRLQQQAQQPLQPQPLPQPQPRSAYTRF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
105	Ubiquitination	LNVDEFVKRVFSVIH CCHHHHHHHHHHHHH	48.44	22790023
237	Phosphorylation	MVIVSLHTFTLLAAS EEEEEHHHHHHHHHH	24.49	-
329	Phosphorylation	IAIKHYFSVVPGNVG EEEEEEEEECCCCCC	18.29	29472430
337	Phosphorylation	VVPGNVGSSPRSSDL ECCCCCCCCCCCHHH	32.65	29472430
338	Phosphorylation	VPGNVGSSPRSSDLV CCCCCCCCCCCHHHH	20.57	29472430
525	Phosphorylation	ESVSSGWTVYRIARQ HHCCCCCHHHHHHHH	15.93	17622165
527	Phosphorylation	VSSGWTVYRIARQAS CCCCCHHHHHHHHHH	6.74	17622165
546	Phosphorylation	HDMARELYQSLLTQV HHHHHHHHHHHHHHH	7.42	30635358
548	Phosphorylation	MARELYQSLLTQVAS HHHHHHHHHHHHHHH	16.28	30635358
551	Phosphorylation	ELYQSLLTQVASEHF HHHHHHHHHHHHHHH	26.70	30635358
555	Phosphorylation	SLLTQVASEHFYFWL HHHHHHHHHHHHHHH	32.52	30635358
559	Phosphorylation	QVASEHFYFWLNSLK HHHHHHHHHHHHHHH	8.85	30635358
564	Phosphorylation	HFYFWLNSLKEFSHA HHHHHHHHHHHCCCH	38.35	30635358
809	Phosphorylation	TSIKLALSPSPRSPA CCEEEECCCCCCCCC	20.09	26824392
811	Phosphorylation	IKLALSPSPRSPAEP EEEECCCCCCCCCCC	29.57	26643407
814	Phosphorylation	ALSPSPRSPAEPIAV ECCCCCCCCCCCEEE	31.67	29233185
867	Ubiquitination	SKSGQDYKIPIDSMT CCCCCCCEEECHHHC	50.74	22790023
929	Ubiquitination	PRTTMFVKSLEDPYS CCCEEEEECCCCHHH	37.75	22790023
935	Phosphorylation	VKSLEDPYSQQIRLQ EECCCCHHHHHHHHH	31.28	22817900
936	Phosphorylation	KSLEDPYSQQIRLQQ ECCCCHHHHHHHHHH	22.46	25367039

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of INT7_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of INT7_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of INT7_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of INT7_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of INT7_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A differential phosphoproteomic analysis of retinoic acid-treated P19cells."; Smith J.C., Duchesne M.A., Tozzi P., Ethier M., Figeys D.; J. Proteome Res. 6:3174-3186(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-525 AND TYR-527, ANDMASS SPECTROMETRY.	17622165 [Abstract]