NXF1_MOUSE - dbPTM
NXF1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NXF1_MOUSE
UniProt AC Q99JX7
Protein Name Nuclear RNA export factor 1
Gene Name Nxf1
Organism Mus musculus (Mouse).
Sequence Length 618
Subcellular Localization Nucleus, nucleoplasm . Nucleus speckle . Cytoplasm . Nucleus . Localized predominantly in the nucleoplasm and at both the nucleoplasmic and cytoplasmic faces of the nuclear pore complex. Shuttles between the nucleus and the cytoplasm. Travels to the
Protein Description Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex. ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export. Also involved in nuclear export of m6A-containing mRNAs: interaction between SRSF3 and YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export..
Protein Sequence MADEGKSYNEHDDRVSFPQRRKKGRGPFRWKCGEGNRRSGRGGSGVQSSRFEEDDGDVAMNDPQDGPRVRYNPYTNRPNRRGDGWHDRDRIHITVRRDRAPAERGGAGTSQDGTTKNWFKITIPYGRKYDKTWLLSMIQSKCSVPFNPIEFHYENTRAHFFVEDATTASALKGVNHKIQDRENRRISIIINASAPPYTVQNELKPEQIEQLKLIMSKRYDGNQQALDLKGLRSDPDLVAQNIDVVLNRRSCMAATLRIIEENIPELLSLNLSSNRLYKLDDMSSIVQKAPNLKTLNLSGNELKTERELDKIKGLKLEELWLDRNPMCDNFGDQSSYISAIRERFPKLLRLDGHELPPPISFDVEAPTMLPPCKGSYFGTENLKSLVLRFLQQYYVIYDSGDRQGLLYAYHDGACCSLSIPYNPQNPVRKNLAEYVKDSRNVKKLKEPTQRFRLLKHTRLNVVAFLNELPKTQHDVNAFVVDISAQTSTLLCFSVNGVFKEVDGKSRDSLRAFTRTFIAVPASNSGLCIVNDELFVRNASPEEIQRAFAMSAPTPSSSPVPTLSPEQQEMLQAFSTQSGMNLEWSQKCLQDNNWDYTRSAQAFTLLKAKGEIPEVAFMK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MADEGKSYN
------CCCCCCCCC		24.46-
41Asymmetric dimethylarginineEGNRRSGRGGSGVQS
CCCCCCCCCCCCCCC		47.77-
41MethylationEGNRRSGRGGSGVQS
CCCCCCCCCCCCCCC		47.7724129315
49PhosphorylationGGSGVQSSRFEEDDG
CCCCCCCCCCCCCCC		24.7327717184
50MethylationGSGVQSSRFEEDDGD
CCCCCCCCCCCCCCC		48.5230988691
74PhosphorylationPRVRYNPYTNRPNRR
CCEECCCCCCCCCCC		17.0129514104
94PhosphorylationDRDRIHITVRRDRAP
CCCCEEEEEECCCCC		8.1921454597
110PhosphorylationERGGAGTSQDGTTKN
HHCCCCCCCCCCCCC		25.9227841257
125NitrationWFKITIPYGRKYDKT
EEEEEEECCCCCCHH		26.2216800626
125NitrationWFKITIPYGRKYDKT
EEEEEEECCCCCCHH		26.2216800626
125Nitrated tyrosineWFKITIPYGRKYDKT
EEEEEEECCCCCCHH		26.22-
187PhosphorylationDRENRRISIIINASA
CCCCCEEEEEEECCC		13.1125266776
197PhosphorylationINASAPPYTVQNELK
EECCCCCCCCCCCCC		20.63-
250PhosphorylationDVVLNRRSCMAATLR
HHHHCHHHHHHHHHH		12.6624719451
283PhosphorylationLYKLDDMSSIVQKAP
EEEHHHHHHHHHHCC		24.7327841257
284PhosphorylationYKLDDMSSIVQKAPN
EEHHHHHHHHHHCCC		21.8227841257
294PhosphorylationQKAPNLKTLNLSGNE
HHCCCCCEECCCCCC		24.8425777480
298PhosphorylationNLKTLNLSGNELKTE
CCCEECCCCCCCCCH		38.2025777480
304PhosphorylationLSGNELKTERELDKI
CCCCCCCCHHHHHHC		53.5525777480
550PhosphorylationIQRAFAMSAPTPSSS
HHHHHHHCCCCCCCC		27.8925159016
553PhosphorylationAFAMSAPTPSSSPVP
HHHHCCCCCCCCCCC		35.2025159016
555PhosphorylationAMSAPTPSSSPVPTL
HHCCCCCCCCCCCCC		46.0225159016
556PhosphorylationMSAPTPSSSPVPTLS
HCCCCCCCCCCCCCC		39.6025159016
557PhosphorylationSAPTPSSSPVPTLSP
CCCCCCCCCCCCCCH		33.9625159016
561PhosphorylationPSSSPVPTLSPEQQE
CCCCCCCCCCHHHHH		39.8525159016
563PhosphorylationSSPVPTLSPEQQEML
CCCCCCCCHHHHHHH		28.9525159016
574PhosphorylationQEMLQAFSTQSGMNL
HHHHHHHHHCCCCCH		28.6625159016
575PhosphorylationEMLQAFSTQSGMNLE
HHHHHHHHCCCCCHH		21.9425159016
577PhosphorylationLQAFSTQSGMNLEWS
HHHHHHCCCCCHHHH		39.8525159016
584PhosphorylationSGMNLEWSQKCLQDN
CCCCHHHHHHHHHCC		15.4725777480
587S-nitrosocysteineNLEWSQKCLQDNNWD
CHHHHHHHHHCCCCC		2.98-
587S-nitrosylationNLEWSQKCLQDNNWD
CHHHHHHHHHCCCCC		2.9820925432
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NXF1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NXF1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NXF1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NUP62_MOUSENup62physical
15820316
NUPL2_HUMANNUPL2physical
15820316
MAP1A_MOUSEMap1aphysical
16014633
MAP1B_MOUSEMap1bphysical
16014633
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NXF1_MOUSE

loading...

Related Literatures of Post-Translational Modification
Nitration
ReferencePubMed
"Endogenously nitrated proteins in mouse brain: links toneurodegenerative disease.";
Sacksteder C.A., Qian W.-J., Knyushko T.V., Wang H., Chin M.H.,Lacan G., Melega W.P., Camp D.G. II, Smith R.D., Smith D.J.,Squier T.C., Bigelow D.J.;
Biochemistry 45:8009-8022(2006).
Cited for: NITRATION [LARGE SCALE ANALYSIS] AT TYR-125, AND MASS SPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory