MCM7_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MCM7_MOUSE
• UniProt AC: Q61881
• Protein Name: DNA replication licensing factor MCM7
• Gene Name: Mcm7
• Organism: Mus musculus (Mouse).
• Sequence Length: 719
• Subcellular Localization: Nucleus.
• Protein Description: Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced damage..
• Protein Sequence: MALKDYAIEKEKVKKFLQEFYYENELGKKQFKYGTQLVHLAHREQVALYVDLDDIAEDDPELVDSICENAKRYSRLFGDVVQELLPEYKEKEVVNKDVLDVYIEHRLMMEQRSRDPGAVRNPQNQYPSELMRRFELYFRGPSSSKPRVIREVRADSVGKLLTVRGIVTRVSEVKPRMVVATYTCDQCGAETYQPIQSPTFMPLIMCPSQECQTNRSGGRLYLQTRGSKFVKFQEMKIQEHSDQVPVGNIPRSITVVLEGENTRIAQPGDHVSVTGIFLPVLRTGFQQMAQGLLSETYLEAHWIVKMTKSDDDVSGAGELSSEELKQIAEEDFYEKLAASIAPEIYGHEDVKKALLLLLVGGVDQSPQGMKIRGNIHICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYGRYNPRRSLEQNVQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSRQPPAQFEPLDMKLMRRYIAMCHERQPTVPESLADYITAAYVEMRREARASKDATYTSARTLLAILRLSTALARLRMVDIVEKEDVNEAIRLMEMSKDSLLGEKGQTARTQRPADVIFATIRELVSRGRSVHFSEAEQRCISRGFTPAQFQAALDEYEELNVWQVNTSRTRITFV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MALKDYAIE ------CCHHHHHHH	24.26	-
6	Phosphorylation	--MALKDYAIEKEKV --CCHHHHHHHHHHH	14.11	25293948
28	Acetylation	YYENELGKKQFKYGT HHHCCCCCCCCCCCC	56.90	23236377
28	Ubiquitination	YYENELGKKQFKYGT HHHCCCCCCCCCCCC	56.90	-
32	Ubiquitination	ELGKKQFKYGTQLVH CCCCCCCCCCCHHHH	40.03	-
156	Phosphorylation	IREVRADSVGKLLTV EEEEECCCHHHHEEE	31.61	24453211
314	Phosphorylation	TKSDDDVSGAGELSS CCCCCCCCCCCCCCH	29.89	26643407
320	Phosphorylation	VSGAGELSSEELKQI CCCCCCCCHHHHHHH	31.25	23429704
321	Phosphorylation	SGAGELSSEELKQIA CCCCCCCHHHHHHHH	47.95	27566939
365	Phosphorylation	LVGGVDQSPQGMKIR HHCCCCCCCCCCEEC	18.09	29514104
388	Phosphorylation	GDPGVAKSQLLSYID CCCCCCHHHHHHHHH	19.14	-
410	Phosphorylation	YTTGRGSSGVGLTAA CCCCCCCCCCCCCEE	40.08	24759943
466	Phosphorylation	HEVMEQQTISIAKAG HHHHHHHCHHHHHHC	19.18	-
468	Phosphorylation	VMEQQTISIAKAGIL HHHHHCHHHHHHCHH	21.63	-
492	Phosphorylation	LAAANPAYGRYNPRR HHHHCCCCCCCCCCC	11.91	-
500	Phosphorylation	GRYNPRRSLEQNVQL CCCCCCCCHHHHCCC	37.22	26824392
513	Phosphorylation	QLPAALLSRFDLLWL CCCHHHHHHCCEEHH	31.58	25159016
562	Phosphorylation	DMKLMRRYIAMCHER CHHHHHHHHHHHHCC	5.22	26239621
648	Ubiquitination	KDSLLGEKGQTARTQ HHHHCCCCCCCCCCC	55.29	-
674	Phosphorylation	ELVSRGRSVHFSEAE HHHHCCCCCCCCHHH	23.83	30387612
678	Phosphorylation	RGRSVHFSEAEQRCI CCCCCCCCHHHHHHH	22.48	28066266

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MCM7_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MCM7_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MCM7_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of MCM7_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.