dbPTM

NU160_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NU160_MOUSE
UniProt AC	Q9Z0W3
Protein Name	Nuclear pore complex protein Nup160
Gene Name	Nup160
Organism	Mus musculus (Mouse).
Sequence Length	1402
Subcellular Localization	Nucleus, nuclear pore complex .
Protein Description	Involved in poly(A)+ RNA transport..
Protein Sequence	MAAAGSLERSFVELSGAERERPRHFREFTVCDIGTASAAFGTVKYSESAGGFYYVESGKLFSITRNRFIHWKTSGDTLELVEESLDLNLLNNAVRLKFQNYNILPGGVHVSETQNHVIILILTNQTVHRLILPHPSRMYRSELVTESQMQSIFTDIGKVDFRDPCNSQLIPSVPGLSPGSTTSAAWLSSDGEALFALPSASGGIFVLKLPPYDVPGIASVVELKQSSVMQRLLTGWMPTAIRGDHGPSDRALSLAVHCVEHDAFIFALCQDHKLRMWSYKDQMCLMVADMLEYVPVNKDLRLTAGTGHKLRLAYSPSMGLYLGIYMHAPKRGQFCVFQLVSTENNRYSLDHISSLFTSQETLVDFALTSTDIWALWHDAENQTIVKYINFEHNVAGQWNPVFMQPLPEEEIVIRDDQDPREMYLRSLFTPGHFINAALCKALQIFCRGTERNLDLSWNELKKEITLAVENELQGSVTEYEFSQDEFRTLQQEFWCKFYACVLQYQEALSHPLALHLNPVTNMVCLLKKGYLSFLVPSSLVDHLYLLPDEHLLTEDETTISDDADVARDVLCLIKCLRMIGESVTMDMAVLMETSCYNLQSPEKAAEHILEDLITIDVENVMEDICSKLQEIRNPVHAIGLLIREMDYETEVEMEKGFDPAQPLNVRMNLSQLYGSSTAGYIVCRGVYKIASTRFLICRDLLILQQLLTRLGDAVILGAGQLFQAQQDLLHRTAPLLLSYYLIKWASQCLATDVPVDTLESNLQHLSVLELTDSGALMANKLVSSPQTIMELFFQEVARKQIISHLFSQPKAPLSQTGLNWPEMITAVTGYLLQLLWPSNPGCLFLECLMGNCQYVQLQDYIQLLHPWCQVNVGSCRFMLGRCYLVTGEVQKALECFCQAASEVGKEEFLDRLIRSEDGEIVSTPKLQYYDKVLRLLDVVGLPELVIQLATSAITEAGDDWKSQATLRTCIFKHHLDLGHNSQAYEALTQIPDSSRQLDCLRQLVVVLCERSQLQDLVEFPYVNLHNEVVGIIESRARAVDLMTHNYYELLYAFHIYRHNYRKAGTVMFEYGMRLGREVRTLRGLEKQGNCYLAAINCLRLIRPEYAWIVQPASGAVSDRPGASPKRNHDGECTAAPTNRQIEILELEDLEKEYSLARIRLTLARHDPSVIAIAGSSSAKEMSALLVQAGLFDTAISLCQTFTLPLTPVFEGLAFKCIKLQFGGEAAQGEAWSWLATNQLSSVITTKESSATDEAWRLLSTYLERYKVQNNLYHHCVINKLLSHGVPLPNWLINSYKKVDAAELLRLYLNYDLLEEAVDLVSEYVDAVLGKGHQYFGIEFPLSATAPMVWLPYSSIDQLLQALGENSANSHNIILSQKILDKLEDYQQKVDKATRDLLYRRDL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	AAGSLERSFVELSGA CCCCCCHHHEECCCC	25.03	-
45	Phosphorylation	AAFGTVKYSESAGGF EECEEEEEECCCCCE	17.21	28285833
306	Phosphorylation	DLRLTAGTGHKLRLA CCEEECCCCCCEEEE	33.38	-
456	Phosphorylation	TERNLDLSWNELKKE CCCCCCCCHHHHHHH	27.76	22817900
465	Phosphorylation	NELKKEITLAVENEL HHHHHHHHHHHHHHH	15.12	-
574	Acetylation	RDVLCLIKCLRMIGE HHHHHHHHHHHHHCC	17.80	22826441
915	Phosphorylation	FLDRLIRSEDGEIVS HHHHHHHCCCCCEEC	32.80	-
931	Ubiquitination	PKLQYYDKVLRLLDV CCHHHHHHHHHHHHH	27.35	-
1105	Phosphorylation	LRLIRPEYAWIVQPA HHHHCCCEEEEEECC	15.21	25159016
1113	Phosphorylation	AWIVQPASGAVSDRP EEEEECCCCCCCCCC	33.69	25521595
1117	Phosphorylation	QPASGAVSDRPGASP ECCCCCCCCCCCCCC	27.63	24925903
1123	Phosphorylation	VSDRPGASPKRNHDG CCCCCCCCCCCCCCC	36.55	24925903
1161	Phosphorylation	SLARIRLTLARHDPS CHHHHHHHHHHCCCC	14.44	17203969
1260	Phosphorylation	EAWRLLSTYLERYKV HHHHHHHHHHHHHCC	31.90	28576409
1381	Acetylation	LSQKILDKLEDYQQK HCHHHHHHHHHHHHH	50.78	23806337
1381	Ubiquitination	LSQKILDKLEDYQQK HCHHHHHHHHHHHHH	50.78	-
1388	Ubiquitination	KLEDYQQKVDKATRD HHHHHHHHHHHHHHH	36.55	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NU160_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NU160_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NU160_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of NU160_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NU160_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry."; Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.; Mol. Cell. Proteomics 8:904-912(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1123, AND MASSSPECTROMETRY.	19131326 [Abstract]
"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry."; Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.; J. Proteome Res. 6:250-262(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1161, AND MASSSPECTROMETRY.	17203969 [Abstract]