P5CR2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: P5CR2_MOUSE
• UniProt AC: Q922Q4
• Protein Name: Pyrroline-5-carboxylate reductase 2
• Gene Name: Pycr2
• Organism: Mus musculus (Mouse).
• Sequence Length: 320
• Subcellular Localization: Cytoplasm . Mitochondrion .
• Protein Description: Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+). Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH (By similarity). Involved in cellular response to oxidative stress (By similarity)..
• Protein Sequence: MSVGFIGAGQLACALARGFTAAGVLSAHKIIASSPDMDLPTVSALRRMGVNLTRSNKDTVRHSDVLFLAVKPHIIPFILDEIGADVQERHIVVSCAAGVTISSVEKKLMAFQPAPKVIRCMTNTPVVVREGATVYATGTHALVEDGKLLEQLMSSVGFCTEVEEDLIDAITGLSGSGPAYAFMALDALADGGVKMGVPRRLAVRLGAQALLGAAKMLLDSEDHPGQLKDNVCSPGGATIHALHFLESGGFRSLLINAVEASCIRTRELQSMADQEKVSPAALKKTLLDRVKLESPTVSTLAPPSSGKLLTRNPAQGSKKE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSVGFIGAG ------CCCCCCCHH	30.83	-
233	Phosphorylation	QLKDNVCSPGGATIH CCCCCEECCCCHHEH	23.46	-
262	S-nitrosocysteine	INAVEASCIRTRELQ HHHHHHHHHCHHHHH	2.92	-
262	Glutathionylation	INAVEASCIRTRELQ HHHHHHHHHCHHHHH	2.92	24333276
262	S-nitrosylation	INAVEASCIRTRELQ HHHHHHHHHCHHHHH	2.92	20925432
278	Phosphorylation	MADQEKVSPAALKKT HHCHHCCCHHHHHHH	21.64	20139300
294	Phosphorylation	LDRVKLESPTVSTLA HHHHCCCCCCCCCCC	35.99	29514104
298	Phosphorylation	KLESPTVSTLAPPSS CCCCCCCCCCCCCCC	21.85	25293948
299	Phosphorylation	LESPTVSTLAPPSSG CCCCCCCCCCCCCCC	23.70	25293948
304	Phosphorylation	VSTLAPPSSGKLLTR CCCCCCCCCCCCCCC	51.14	25293948
305	Phosphorylation	STLAPPSSGKLLTRN CCCCCCCCCCCCCCC	45.80	25293948
307	Acetylation	LAPPSSGKLLTRNPA CCCCCCCCCCCCCCC	42.12	23236377
317	Phosphorylation	TRNPAQGSKKE---- CCCCCCCCCCC----	28.60	25338131

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of P5CR2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of P5CR2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of P5CR2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of P5CR2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.