PAX3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PAX3_MOUSE
• UniProt AC: P24610
• Protein Name: Paired box protein Pax-3
• Gene Name: Pax3
• Organism: Mus musculus (Mouse).
• Sequence Length: 479
• Subcellular Localization: Nucleus .
• Protein Description: Transcription factor that may regulate cell proliferation, migration and apoptosis. Involved in neural development and myogenesis. Transcriptional activator of MITF, acting synergistically with SOX10 (By similarity)..
• Protein Sequence: MTTLAGAVPRMMRPGPGQNYPRSGFPLEVSTPLGQGRVNQLGGVFINGRPLPNHIRHKIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRPGAIGGSKPKQVTTPDVEKKIEEYKRENPGMFSWEIRDKLLKDAVCDRNTVPSVSSISRILRSKFGKGEEEEADLERKEAEESEKKAKHSIDGILSERASAPQSDEGSDIDSEPDLPLKRKQRRSRTTFTAEQLEELERAFERTHYPDIYTREELAQRAKLTEARVQVWFSNRRARWRKQAGANQLMAFNHLIPGGFPPTAMPTLPTYQLSETSYQPTSIPQAVSDPSSTVHRPQPLPPSTVHQSTIPSNADSSSAYCLPSTRHGFSSYTDSFVPPSGPSNPMNPTIGNGLSPQVMGLLTNHGGVPHQPQTDYALSPLTGGLEPTTTVSASCSQRLEHMKNVDSLPTSQPYCPPTYSTAGYSMDPVTGYQYGQYGQSKPWTF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTTLAGAVP ------CCCHHCCCC	30.43	28576409
3	Phosphorylation	-----MTTLAGAVPR -----CCCHHCCCCC	17.20	25159016
20	Phosphorylation	RPGPGQNYPRSGFPL CCCCCCCCCCCCCCC	7.67	25159016
23	Phosphorylation	PGQNYPRSGFPLEVS CCCCCCCCCCCCEEE	40.04	25159016
197	Phosphorylation	GILSERASAPQSDEG HHHHCCCCCCCCCCC	46.86	29550500
201	Phosphorylation	ERASAPQSDEGSDID CCCCCCCCCCCCCCC	36.25	21440083
205	Phosphorylation	APQSDEGSDIDSEPD CCCCCCCCCCCCCCC	29.37	21440083
209	Phosphorylation	DEGSDIDSEPDLPLK CCCCCCCCCCCCCCC	51.90	21440083

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
201	S	Phosphorylation	Kinase	GSK3B	P49841	PSP
205	S	Phosphorylation	Kinase	CK2A1	P68400	PSP
205	S	Phosphorylation	Kinase	CSNK2A1	Q60737	GPS
205	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
209	S	Phosphorylation	Kinase	CSNK2A1	Q60737	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PAX3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PAX3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HIRA_MOUSE	Hira	physical	9731536
CIB1_HUMAN	CIB1	physical	11997098
CIB1_HUMAN	CIB1	genetic	11997098
CBX3_HUMAN	CBX3	physical	16945326
CBX5_HUMAN	CBX5	physical	16945326
TIF1B_HUMAN	TRIM28	physical	16945326
TLE4_MOUSE	Tle4	physical	15729346
CTNB1_MOUSE	Ctnnb1	genetic	15729346
SIR1_MOUSE	Sirt1	physical	21169561
P53_MOUSE	Trp53	physical	22216266
MDM2_MOUSE	Mdm2	physical	22216266
LEF1_MOUSE	Lef1	physical	20006729
CTNB1_MOUSE	Ctnnb1	physical	20006729
WWTR1_MOUSE	Wwtr1	physical	16300735

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.