HIRA_MOUSE - dbPTM
HIRA_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HIRA_MOUSE
UniProt AC Q61666
Protein Name Protein HIRA
Gene Name Hira
Organism Mus musculus (Mouse).
Sequence Length 1015
Subcellular Localization Nucleus. Nucleus, PML body. Primarily, though not exclusively, localized to the nucleus (By similarity). Localizes to PML bodies immediately prior to onset of senescence (By similarity). Localizes specifically to the male nucleus in fertilized eggs.
Protein Description Required for the periodic repression of histone gene transcription during the cell cycle (By similarity). Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit..
Protein Sequence MKLLKPTWVNHNGKPIFSVDIHPDGTKFATGGQGQDSGKVVIWNMSPVLQEDDEKDENIPKMLCQMDNHLACVNCVRWSNSGMYLASGGDDKLIMVWKRATYIGPSTVFGSSGKLANVEQWRCVSILRSHSGDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPEILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWRTLDWQLETSITKPFDECGGTTHVLRLSWSPDGHYLVSAHAMNNSGPTAQIIEREGWKTNMDFVGHRKAVTVVKFNPKIFKKKQKNGSSTKPSCPYCCCAVGSKDRSLSVWLTCLKRPLVVIHELFDKSIMDISWTLNGLGILVCSMDGSVAFLDFSQDELGDPLSEEEKSRIHQSTYGKSLAIMTEAQLSTAVIENPEMLKYQRRQQQQQLDQKNATTRETSSASSVTGVVNGESLEDIRKNLLKKQVETRTADGRRRITPLCIAQLDTGDFSTAFFNSIPLSSSLAGTMLSSPSGQQLLPLDSSTPSFGASKPCTEPVAATSARPTGESVSKDSMNATSTPAASSPSVLTTPSKIEPMKAFDSRFTERSKATPGAPSLTSVIPTAVERLKEQNLVKELRSRELESSSDSDEKVHLAKPSSLSKRKLELEVETVEKKKKGRPRKDSRLLPMSLSVQSPAALSTEKEAMCLSAPALALKLPIPGPQRAFTLQVSSDPSMYIEVENEVTTVGGIRLSRLKCNREGKEWETVLSSRVLTAAGSCDVVCVACEKRMLSVFSTCGRRLLPPILLPSPISTLHCTGPYVMALTAAATLSVWDVHRQVVVVKEESLHSILSGSDMTVSQILLTQHGIPVMNLSDGKAYCFNPSLSTWNLVSDKQDSLAQCADFRNSLPSQDAMLCSGPLAIIQGRTSNSGRQAARLFSVPHVVQQETTLAYLENQVAAALTLQSSHEYRHWLLLYARYLVNEGFEYRLREICKDLLGPVHCSTGSQWESTVVGLRKRELLKELLPVIGQNLRFQRLFTECQEQLDILRDK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
7 (in isoform 4)Phosphorylation-40.2230352176
7Phosphorylation-MKLLKPTWVNHNGK
-CCCCCCEEECCCCE		40.22-
46PhosphorylationKVVIWNMSPVLQEDD
CEEEEECCCCCCCCC		14.5127357545
111PhosphorylationGPSTVFGSSGKLANV
CCCHHCCCCCCCCCH		25.1822006019
114AcetylationTVFGSSGKLANVEQW
HHCCCCCCCCCHHHH		46.5022826441
424PhosphorylationNATTRETSSASSVTG
CCCHHHCCCCCCEEE		21.1025266776
524PhosphorylationCTEPVAATSARPTGE
CCCCCCCCCCCCCCC		17.1223375375
532PhosphorylationSARPTGESVSKDSMN
CCCCCCCCCCCCCCC		32.7930352176
534PhosphorylationRPTGESVSKDSMNAT
CCCCCCCCCCCCCCC		39.7727841257
537PhosphorylationGESVSKDSMNATSTP
CCCCCCCCCCCCCCC		20.0628576409
541PhosphorylationSKDSMNATSTPAASS
CCCCCCCCCCCCCCC		28.2929472430
542PhosphorylationKDSMNATSTPAASSP
CCCCCCCCCCCCCCC		29.9529472430
543PhosphorylationDSMNATSTPAASSPS
CCCCCCCCCCCCCCC		16.7629472430
547PhosphorylationATSTPAASSPSVLTT
CCCCCCCCCCCCCCC		44.9126239621
548PhosphorylationTSTPAASSPSVLTTP
CCCCCCCCCCCCCCC		19.2326239621
550PhosphorylationTPAASSPSVLTTPSK
CCCCCCCCCCCCCCC		31.5426239621
553PhosphorylationASSPSVLTTPSKIEP
CCCCCCCCCCCCCCC		34.2126239621
554PhosphorylationSSPSVLTTPSKIEPM
CCCCCCCCCCCCCCC		22.7726239621
556PhosphorylationPSVLTTPSKIEPMKA
CCCCCCCCCCCCCCH		44.1423984901
566PhosphorylationEPMKAFDSRFTERSK
CCCCHHCCHHHCHHC		23.88-
572PhosphorylationDSRFTERSKATPGAP
CCHHHCHHCCCCCCC		22.02-
575PhosphorylationFTERSKATPGAPSLT
HHCHHCCCCCCCCHH		26.45-
580PhosphorylationKATPGAPSLTSVIPT
CCCCCCCCHHHHCHH		43.69-
582PhosphorylationTPGAPSLTSVIPTAV
CCCCCCHHHHCHHHH		25.86-
583PhosphorylationPGAPSLTSVIPTAVE
CCCCCHHHHCHHHHH		24.28-
599AcetylationLKEQNLVKELRSREL
HHHCCHHHHHHHCCC		54.9522826441
608PhosphorylationLRSRELESSSDSDEK
HHHCCCCCCCCCCCC		48.0128066266
609PhosphorylationRSRELESSSDSDEKV
HHCCCCCCCCCCCCE		28.8728066266
610PhosphorylationSRELESSSDSDEKVH
HCCCCCCCCCCCCEE		50.8728066266
612PhosphorylationELESSSDSDEKVHLA
CCCCCCCCCCCEEEC		50.0128066266
623PhosphorylationVHLAKPSSLSKRKLE
EEECCCCHHCHHEEE		45.2329514104
648PhosphorylationKGRPRKDSRLLPMSL
CCCCCCCCCCCCCCC		28.0625266776
654PhosphorylationDSRLLPMSLSVQSPA
CCCCCCCCCEECCCC		18.6226239621
656PhosphorylationRLLPMSLSVQSPAAL
CCCCCCCEECCCCCC		15.7126239621
659PhosphorylationPMSLSVQSPAALSTE
CCCCEECCCCCCCCH		17.8526239621
664PhosphorylationVQSPAALSTEKEAMC
ECCCCCCCCHHHHHH		29.7829472430
665PhosphorylationQSPAALSTEKEAMCL
CCCCCCCCHHHHHHH		52.5029472430
673PhosphorylationEKEAMCLSAPALALK
HHHHHHHCCCHHHHC		27.55-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HIRA_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
554TPhosphorylation

11238922
554TPhosphorylation

11238922
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HIRA_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
HIRP3_MOUSEHirip3physical
9731536
PAX3_MOUSEPax3physical
9731536
PAX7_MOUSEPax7physical
9731536
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HIRA_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"HIRA, the human homologue of yeast Hir1p and Hir2p, is a novelcyclin-cdk2 substrate whose expression blocks S-phase progression.";
Hall C., Nelson D.M., Ye X., Baker K., DeCaprio J.A., Seeholzer S.,Lipinski M., Adams P.D.;
Mol. Cell. Biol. 21:1854-1865(2001).
Cited for: PHOSPHORYLATION AT THR-554.

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