dbPTM

HIRP3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	HIRP3_MOUSE
UniProt AC	Q8BLH7
Protein Name	HIRA-interacting protein 3
Gene Name	Hirip3 {ECO:0000312\|MGI:MGI:2142364}
Organism	Mus musculus (Mouse).
Sequence Length	601
Subcellular Localization	Nucleus . Nuclear throughout the cell cycle and is excluded from condensed chromatin during mitosis.
Protein Description	May play a role in chromatin function and histone metabolism via its interaction with HIRA and histones..
Protein Sequence	MAPGDEMRKFTRSFFRACPDLSSVTHAIVRQKFLIHVGRDHLEPEEKQALKRLVEEELPKMQADAGTREGKPDFIKVKRSPAPCSDPKKKRFRFNSESESSSSPSSPDGSGPSTKNRTTKKTCLRRALKKAVESTDEDHQTDLDAKMGLEESSEGEAEGSVRSGKVTEEEEDMKQEQKGQVRKQAGAKDKQVPLKADRKQVREESGSSEEEAVLQRAKVEGSTGANCQEESEESGEESPAKKKELSEPRSRSNRAERTARERKSYKQKSRPGRPTGGLRDSEAEKEGGTVGSGDSSEEGEAEKEGGTVGSGDSSEKGEAEKEEGTVGSGDSSEEGEEHSVKRKSKVRTQTESGRRQNTSSRDDSNSTQEQAAAQGTTKSGSLGSSNGDSDTEREVSDSQAGQNTKEERKSRSSNKSSKNGQARSCSSSSDSSPEPTGQKGKARSSSSSSDSGPEPTGRKAASRCGEDHPAVARLKRYIRACGAHRNYKKLLGSCSSHKARLSVLRAELEALGMKGNPSLEKCRALKLQREEAAEVAALDVANIISSTGRPRRRNAWNPSGEGTSPGETYRRTLDSEEEQPRQAPPDWSHMRDIISSDGDSS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Glutathionylation	TRSFFRACPDLSSVT HHHHHHHCCCHHHHH	2.04	24333276
47	Ubiquitination	DHLEPEEKQALKRLV HHCCHHHHHHHHHHH	38.93	-
80	Phosphorylation	DFIKVKRSPAPCSDP CCEEECCCCCCCCCC	21.50	25521595
85	Phosphorylation	KRSPAPCSDPKKKRF CCCCCCCCCCCCCCC	56.75	25159016
96	Phosphorylation	KKRFRFNSESESSSS CCCCCCCCCCCCCCC	39.52	22942356
98	Phosphorylation	RFRFNSESESSSSPS CCCCCCCCCCCCCCC	42.47	25619855
100	Phosphorylation	RFNSESESSSSPSSP CCCCCCCCCCCCCCC	44.81	25619855
101	Phosphorylation	FNSESESSSSPSSPD CCCCCCCCCCCCCCC	30.68	26643407
102	Phosphorylation	NSESESSSSPSSPDG CCCCCCCCCCCCCCC	56.39	23970565
103	Phosphorylation	SESESSSSPSSPDGS CCCCCCCCCCCCCCC	30.65	26745281
105	Phosphorylation	SESSSSPSSPDGSGP CCCCCCCCCCCCCCC	57.35	26643407
106	Phosphorylation	ESSSSPSSPDGSGPS CCCCCCCCCCCCCCC	30.32	25619855
110	Phosphorylation	SPSSPDGSGPSTKNR CCCCCCCCCCCCCCC	55.71	22802335
113	Phosphorylation	SPDGSGPSTKNRTTK CCCCCCCCCCCCCCH	56.38	22802335
114	Phosphorylation	PDGSGPSTKNRTTKK CCCCCCCCCCCCCHH	35.16	25619855
134	Phosphorylation	ALKKAVESTDEDHQT HHHHHHHCCCCCHHH	34.26	27087446
135	Phosphorylation	LKKAVESTDEDHQTD HHHHHHCCCCCHHHH	29.87	27087446
141	Phosphorylation	STDEDHQTDLDAKMG CCCCCHHHHHHHHCC	34.80	25521595
152	Phosphorylation	AKMGLEESSEGEAEG HHCCCCCCCCCCCCC	25.06	27087446
153	Phosphorylation	KMGLEESSEGEAEGS HCCCCCCCCCCCCCC	53.56	27087446
160	Phosphorylation	SEGEAEGSVRSGKVT CCCCCCCCCCCCCCC	13.08	22802335
163	Phosphorylation	EAEGSVRSGKVTEEE CCCCCCCCCCCCHHH	40.59	23684622
167	Phosphorylation	SVRSGKVTEEEEDMK CCCCCCCCHHHHHHH	40.96	23684622
205	Phosphorylation	RKQVREESGSSEEEA HHHHHHHCCCCHHHH	38.94	27087446
207	Phosphorylation	QVREESGSSEEEAVL HHHHHCCCCHHHHHH	43.80	27087446
208	Phosphorylation	VREESGSSEEEAVLQ HHHHCCCCHHHHHHH	53.18	27087446
222	Phosphorylation	QRAKVEGSTGANCQE HHHHHCCCCCCCCHH	15.34	25619855
223	Phosphorylation	RAKVEGSTGANCQEE HHHHCCCCCCCCHHH	51.69	25619855
231	Phosphorylation	GANCQEESEESGEES CCCCHHHHHHCCCCC	46.00	25521595
234	Phosphorylation	CQEESEESGEESPAK CHHHHHHCCCCCHHH	47.67	25521595
238	Phosphorylation	SEESGEESPAKKKEL HHHCCCCCHHHHHHC	26.34	27087446
246	Phosphorylation	PAKKKELSEPRSRSN HHHHHHCCCCCHHHH	46.80	22817900
264	Phosphorylation	RTARERKSYKQKSRP HHHHHHHHHHCCCCC	43.73	24719451
265	Phosphorylation	TARERKSYKQKSRPG HHHHHHHHHCCCCCC	22.07	24719451
269	Phosphorylation	RKSYKQKSRPGRPTG HHHHHCCCCCCCCCC	41.01	25777480
281	Phosphorylation	PTGGLRDSEAEKEGG CCCCCCCHHHHHCCC	32.07	29233185
289	Phosphorylation	EAEKEGGTVGSGDSS HHHHCCCCCCCCCCC	32.33	21149613
292	Phosphorylation	KEGGTVGSGDSSEEG HCCCCCCCCCCCCCC	34.78	21149613
295	Phosphorylation	GTVGSGDSSEEGEAE CCCCCCCCCCCCCCC	43.08	27087446
296	Phosphorylation	TVGSGDSSEEGEAEK CCCCCCCCCCCCCCC	44.39	27087446
307	Phosphorylation	EAEKEGGTVGSGDSS CCCCCCCCCCCCCCC	32.33	29550500
310	Phosphorylation	KEGGTVGSGDSSEKG CCCCCCCCCCCCCCC	34.78	23375375
313	Phosphorylation	GTVGSGDSSEKGEAE CCCCCCCCCCCCCCC	43.87	27087446
314	Phosphorylation	TVGSGDSSEKGEAEK CCCCCCCCCCCCCCC	48.33	24899341
325	Phosphorylation	EAEKEEGTVGSGDSS CCCCCCCCCCCCCCC	25.60	21149613
328	Phosphorylation	KEEGTVGSGDSSEEG CCCCCCCCCCCCCCC	34.78	25521595
331	Phosphorylation	GTVGSGDSSEEGEEH CCCCCCCCCCCCCCC	43.08	25521595
332	Phosphorylation	TVGSGDSSEEGEEHS CCCCCCCCCCCCCCC	44.39	27087446
339	Phosphorylation	SEEGEEHSVKRKSKV CCCCCCCCCCHHHCC	32.39	21743459
359	Phosphorylation	SGRRQNTSSRDDSNS CCCCCCCCCCCCCCC	30.81	-
360	Phosphorylation	GRRQNTSSRDDSNST CCCCCCCCCCCCCCH	37.38	28285833
364	Phosphorylation	NTSSRDDSNSTQEQA CCCCCCCCCCHHHHH	36.65	22006019
366	Phosphorylation	SSRDDSNSTQEQAAA CCCCCCCCHHHHHHH	35.11	25266776
379	Phosphorylation	AAQGTTKSGSLGSSN HHHCCCCCCCCCCCC	31.36	25619855
381	Phosphorylation	QGTTKSGSLGSSNGD HCCCCCCCCCCCCCC	36.33	25619855
384	Phosphorylation	TKSGSLGSSNGDSDT CCCCCCCCCCCCCCC	26.39	21082442
385	Phosphorylation	KSGSLGSSNGDSDTE CCCCCCCCCCCCCCC	42.93	21082442
389	Phosphorylation	LGSSNGDSDTEREVS CCCCCCCCCCCHHCC	48.07	27087446
391	Phosphorylation	SSNGDSDTEREVSDS CCCCCCCCCHHCCHH	40.68	21082442
396	Phosphorylation	SDTEREVSDSQAGQN CCCCHHCCHHHHCCC	27.13	21082442
398	Phosphorylation	TEREVSDSQAGQNTK CCHHCCHHHHCCCHH	17.90	22802335
404	Phosphorylation	DSQAGQNTKEERKSR HHHHCCCHHHHHHHH	31.76	25619855
424	Phosphorylation	SKNGQARSCSSSSDS CCCCCCCCCCCCCCC	22.74	27149854
426	Phosphorylation	NGQARSCSSSSDSSP CCCCCCCCCCCCCCC	34.20	27149854
427	Phosphorylation	GQARSCSSSSDSSPE CCCCCCCCCCCCCCC	37.88	27149854
428	Phosphorylation	QARSCSSSSDSSPEP CCCCCCCCCCCCCCC	23.13	27149854
429	Phosphorylation	ARSCSSSSDSSPEPT CCCCCCCCCCCCCCC	43.38	27149854
431	Phosphorylation	SCSSSSDSSPEPTGQ CCCCCCCCCCCCCCC	50.14	27149854
432	Phosphorylation	CSSSSDSSPEPTGQK CCCCCCCCCCCCCCC	37.97	27149854
436	Phosphorylation	SDSSPEPTGQKGKAR CCCCCCCCCCCCCCC	51.05	27149854
444	Phosphorylation	GQKGKARSSSSSSDS CCCCCCCCCCCCCCC	39.16	23375375
445	Phosphorylation	QKGKARSSSSSSDSG CCCCCCCCCCCCCCC	28.78	23375375
446	Phosphorylation	KGKARSSSSSSDSGP CCCCCCCCCCCCCCC	35.17	29550500
447	Phosphorylation	GKARSSSSSSDSGPE CCCCCCCCCCCCCCC	35.49	29550500
448	Phosphorylation	KARSSSSSSDSGPEP CCCCCCCCCCCCCCC	39.86	23375375
449	Phosphorylation	ARSSSSSSDSGPEPT CCCCCCCCCCCCCCC	37.43	29550500
451	Phosphorylation	SSSSSSDSGPEPTGR CCCCCCCCCCCCCCH	59.19	29550500
502	Phosphorylation	SSHKARLSVLRAELE HHHHHHHHHHHHHHH	17.35	24719451
545	Phosphorylation	LDVANIISSTGRPRR HHHHHHHHCCCCCCC	20.32	26643407
546	Phosphorylation	DVANIISSTGRPRRR HHHHHHHCCCCCCCC	25.19	25266776
547	Phosphorylation	VANIISSTGRPRRRN HHHHHHCCCCCCCCC	30.35	25777480
559	Phosphorylation	RRNAWNPSGEGTSPG CCCCCCCCCCCCCCC	46.38	23684622
563	Phosphorylation	WNPSGEGTSPGETYR CCCCCCCCCCCCCCC	27.69	23684622
564	Phosphorylation	NPSGEGTSPGETYRR CCCCCCCCCCCCCCC	41.59	23684622
568	Phosphorylation	EGTSPGETYRRTLDS CCCCCCCCCCCCCCC	28.39	23684622
569	Phosphorylation	GTSPGETYRRTLDSE CCCCCCCCCCCCCCC	8.19	25619855
572	Phosphorylation	PGETYRRTLDSEEEQ CCCCCCCCCCCCCCC	26.39	25159016
575	Phosphorylation	TYRRTLDSEEEQPRQ CCCCCCCCCCCCCCC	50.44	27087446
595	Phosphorylation	SHMRDIISSDGDSS- HHHHHHHCCCCCCC-	23.78	23737553
596	Phosphorylation	HMRDIISSDGDSS-- HHHHHHCCCCCCC--	34.89	23737553
600	Phosphorylation	IISSDGDSS------ HHCCCCCCC------	43.40	23737553
601	Phosphorylation	ISSDGDSS------- HCCCCCCC-------	49.32	23737553

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of HIRP3_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of HIRP3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of HIRP3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of HIRP3_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of HIRP3_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-141; SER-152; SER-153;SER-231 AND SER-234, AND MASS SPECTROMETRY.	17242355 [Abstract]
"A differential phosphoproteomic analysis of retinoic acid-treated P19cells."; Smith J.C., Duchesne M.A., Tozzi P., Ethier M., Figeys D.; J. Proteome Res. 6:3174-3186(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-205; SER-207; SER-208;THR-289; SER-295 AND SER-296, AND MASS SPECTROMETRY.	17622165 [Abstract]