TLE4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TLE4_MOUSE
• UniProt AC: Q62441
• Protein Name: Transducin-like enhancer protein 4
• Gene Name: Tle4
• Organism: Mus musculus (Mouse).
• Sequence Length: 773
• Subcellular Localization: Nucleus .
• Protein Description: Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression..
• Protein Sequence: MIRDLSKMYPQTRHPAPHQPAQPFKFTISESCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLNAICAQVIPFLSQEHQQQVVQAVERAKQVTMAELNAIIGQQLQAQHLSHGHGLPVPLTPHPSGLQPPAIPPIGSSAGLLALSSALGGQSHLPIKDEKKHHDNDHQRDRDSIKSSSVSPSASFRGSEKHRNSTDYSSESKKQKTEEKEIAARYDSDGEKSDDNLVVDVSNEDPSSPRGSPAHSPRENGLDKTRLLKKDAPISPASVASSSSTPSSKSKELSLNEKSTTPVSKSNTPTPRTDAPTPGSNSTPGLRPVPGKPPGVDPLASSLRTPMAVPCPYPTPFGIVPHAGMNGELTSPGAAYAGLHNISPQMSAAAAAAAAAAAYGRSPVVGFDPHHHMRVPAIPPNLTGIPGGKPAYSFHVSADGQMQPVPFPPDALIGPGIPRHARQINTLNHGEVVCAVTISNPTRHVYTGGKGCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCRLLPDGRTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMENSNVEVLHVTKPDKYQLHLHESCVLSLKFAHCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISVDDKYIVTGSGDKKATVYEVIY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	Phosphorylation	PAQPFKFTISESCDR CCCCCEEEECHHHHH	24.96	21183079
201	Phosphorylation	DHQRDRDSIKSSSVS CCCCCHHHHHHCCCC	32.58	22942356
204	Phosphorylation	RDRDSIKSSSVSPSA CCHHHHHHCCCCCCH	26.61	23527152
205	Phosphorylation	DRDSIKSSSVSPSAS CHHHHHHCCCCCCHH	29.74	23527152
206	Phosphorylation	RDSIKSSSVSPSASF HHHHHHCCCCCCHHC	33.43	22942356
208	Phosphorylation	SIKSSSVSPSASFRG HHHHCCCCCCHHCCC	18.32	25521595
210	Phosphorylation	KSSSVSPSASFRGSE HHCCCCCCHHCCCCH	29.10	20469934
212	Phosphorylation	SSVSPSASFRGSEKH CCCCCCHHCCCCHHC	21.58	28833060
216	Phosphorylation	PSASFRGSEKHRNST CCHHCCCCHHCCCCC	38.93	-
222	Phosphorylation	GSEKHRNSTDYSSES CCHHCCCCCCCCCHH	23.70	25266776
223	Phosphorylation	SEKHRNSTDYSSESK CHHCCCCCCCCCHHH	42.37	29550500
226	Phosphorylation	HRNSTDYSSESKKQK CCCCCCCCCHHHHHH	30.36	29550500
227	Phosphorylation	RNSTDYSSESKKQKT CCCCCCCCHHHHHHC	39.39	25266776
229	Phosphorylation	STDYSSESKKQKTEE CCCCCCHHHHHHCHH	47.29	25266776
237	Acetylation	KKQKTEEKEIAARYD HHHHCHHHHHHHHCC	48.46	23954790
243	Phosphorylation	EKEIAARYDSDGEKS HHHHHHHCCCCCCCC	18.31	21149613
245	Phosphorylation	EIAARYDSDGEKSDD HHHHHCCCCCCCCCC	38.28	21149613
250	Phosphorylation	YDSDGEKSDDNLVVD CCCCCCCCCCCEEEE	45.99	21149613
259	Phosphorylation	DNLVVDVSNEDPSSP CCEEEECCCCCCCCC	30.00	25293948
264	Phosphorylation	DVSNEDPSSPRGSPA ECCCCCCCCCCCCCC	66.35	21149613
265	Phosphorylation	VSNEDPSSPRGSPAH CCCCCCCCCCCCCCC	24.81	21149613
269	Phosphorylation	DPSSPRGSPAHSPRE CCCCCCCCCCCCCCC	21.86	21149613
273	Phosphorylation	PRGSPAHSPRENGLD CCCCCCCCCCCCCCC	27.97	21149613
281	Acetylation	PRENGLDKTRLLKKD CCCCCCCHHHHCCCC	40.36	-
292	Phosphorylation	LKKDAPISPASVASS CCCCCCCCHHHHHCC	17.22	25521595
295	Phosphorylation	DAPISPASVASSSST CCCCCHHHHHCCCCC	22.92	22942356
298	Phosphorylation	ISPASVASSSSTPSS CCHHHHHCCCCCCCC	28.70	25619855
299	Phosphorylation	SPASVASSSSTPSSK CHHHHHCCCCCCCCC	20.69	25619855
300	Phosphorylation	PASVASSSSTPSSKS HHHHHCCCCCCCCCC	35.42	25619855
301	Phosphorylation	ASVASSSSTPSSKSK HHHHCCCCCCCCCCC	46.41	25619855
302	Phosphorylation	SVASSSSTPSSKSKE HHHCCCCCCCCCCCC	29.19	25619855
304	Phosphorylation	ASSSSTPSSKSKELS HCCCCCCCCCCCCCC	50.95	25619855
305	Phosphorylation	SSSSTPSSKSKELSL CCCCCCCCCCCCCCC	42.00	25619855
318	Phosphorylation	SLNEKSTTPVSKSNT CCCCCCCCCCCCCCC	28.87	19060867
321	Phosphorylation	EKSTTPVSKSNTPTP CCCCCCCCCCCCCCC	31.41	19060867
323	Phosphorylation	STTPVSKSNTPTPRT CCCCCCCCCCCCCCC	38.13	30635358
325	Phosphorylation	TPVSKSNTPTPRTDA CCCCCCCCCCCCCCC	35.31	19060867
327	Phosphorylation	VSKSNTPTPRTDAPT CCCCCCCCCCCCCCC	24.30	30635358
330	Phosphorylation	SNTPTPRTDAPTPGS CCCCCCCCCCCCCCC	37.40	-
330	O-linked_Glycosylation	SNTPTPRTDAPTPGS CCCCCCCCCCCCCCC	37.40	51587809
334	Phosphorylation	TPRTDAPTPGSNSTP CCCCCCCCCCCCCCC	41.84	-
340	Phosphorylation	PTPGSNSTPGLRPVP CCCCCCCCCCCCCCC	26.15	-
419	Phosphorylation	AAAAYGRSPVVGFDP HHHHHCCCCCCCCCC	20.06	-
706	Phosphorylation	LHESCVLSLKFAHCG EECHHHHEEEECCCC	14.76	30387612
721	Ubiquitination	KWFVSTGKDNLLNAW CEEEECCCCHHHHHH	43.46	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
250	S	Phosphorylation	Kinase	CK2	-	Uniprot
265	S	Phosphorylation	Kinase	CDK1	P11440	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TLE4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TLE4_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SIX3_MOUSE	Six3	physical	12050133
SIX6_MOUSE	Six6	physical	12050133
OPTIX_DROME	Optix	physical	12050133
PAX3_MOUSE	Pax3	physical	15729346
TLE4_MOUSE	Tle4	physical	16002402
AES_MOUSE	Aes	physical	16002402
MSX1_MOUSE	Msx1	physical	16002402
PO2F1_MOUSE	Pou2f1	physical	16002402

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.