MSX1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MSX1_MOUSE
• UniProt AC: P13297
• Protein Name: Homeobox protein MSX-1
• Gene Name: Msx1
• Organism: Mus musculus (Mouse).
• Sequence Length: 303
• Subcellular Localization: Nucleus.
• Protein Description: Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis..
• Protein Sequence: MAPAAAMTSLPLGVKVEDSAFAKPAGGGVGQAPGAAAATATAMGTDEEGAKPKVPASLLPFSVEALMADHRKPGAKESVLVASEGAQAAGGSVQHLGTRPGSLGAPDAPSSPRPLGHFSVGGLLKLPEDALVKAESPEKLDRTPWMQSPRFSPPPARRLSPPACTLRKHKTNRKPRTPFTTAQLLALERKFRQKQYLSIAERAEFSSSLSLTETQVKIWFQNRRAKAKRLQEAELEKLKMAAKPMLPPAAFGLSFPLGGPAAVAAAAGASLYSASGPFQRAALPVAPVGLYTAHVGYSMYHLT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Sumoylation	TSLPLGVKVEDSAFA CCCCCCCEEECCCCC	11.84	-
133	Sumoylation	LPEDALVKAESPEKL CCHHHCEECCCHHHH	60.10	-
150	Dimethylation	TPWMQSPRFSPPPAR CCCCCCCCCCCCCHH	18.26	-
150	Methylation	TPWMQSPRFSPPPAR CCCCCCCCCCCCCHH	18.26	18962877
152	Phosphorylation	WMQSPRFSPPPARRL CCCCCCCCCCCHHHC	41.44	27180971
157	Dimethylation	RFSPPPARRLSPPAC CCCCCCHHHCCCCCC	11.43	-
157	Methylation	RFSPPPARRLSPPAC CCCCCCHHHCCCCCC	11.43	18962885

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MSX1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MSX1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MSX1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TBP_MOUSE	Tbp	physical	20211142
TLE4_MOUSE	Tle4	physical	16002402
AES_MOUSE	Aes	physical	16002402
MSX1_MOUSE	Msx1	physical	16002402
PO2F1_MOUSE	Pou2f1	physical	16002402
H15_MOUSE	Hist1h1b	physical	15192231
H11_MOUSE	Hist1h1a	physical	15192231
MSHR_MOUSE	Mc1r	physical	9454589
MC3R_MOUSE	Mc3r	physical	9454589
MC4R_MOUSE	Mc4r	physical	9454589

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Sumoylation

"Modification of Msx1 by SUMO-1.";
Gupta V., Bei M.;
Biochem. Biophys. Res. Commun. 345:74-77(2006).
Cited for: SUMOYLATION AT LYS-9 AND LYS-127, AND MUTAGENESIS OF LYS-9; LYS-47;LYS-66; LYS-119; LYS-127 AND LYS-133.
PubMed: 16678795