PO2F1_MOUSE - dbPTM
PO2F1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PO2F1_MOUSE
UniProt AC P25425
Protein Name POU domain, class 2, transcription factor 1
Gene Name Pou2f1
Organism Mus musculus (Mouse).
Sequence Length 770
Subcellular Localization Nucleus.
Protein Description Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity)..
Protein Sequence MNNPSETNKSSMESEDASTGTQTNGLDFQKQPVPVGGAISTAQAQAFLGHLHQVQLAGTSLQAAAQSLNVQSKSSEESGDSQQSSQPSSQPPSVQSAIPQTQLMLAGGQITGLTLTPAQQQLLLQQAQAQAQLLAAAVQQHSASQQHSAAGATISASAATPMTQIPLSQPIQIAQDLQQLQQLQQQNLNLQQFVLVHPTTNLQPAQFIISQTPQGQQGLLQAQNLLTQLPQQSQANLLQPQPSITLTSQPTTPTRTIAAASVQTLPQSQSTPKRIDTPSLEEPSDLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAENLSSDSTASSPSALNSPGLGAEGLNRRRKKRTSIETNIRVALEKSFMENQKPTSEDITLIAEQLNMEKEVIRVWFCNRRQKEKRINPPSSGGTSSSPIKAIFPSPASLVATTPSLVTSSTATTLTVNPVLPLTSAAVTNLSLTDQDLRRGCSWEVLRSLPDRVTTTAGTTDSTSNNNTATVISTAPPASSAVTSPSLSPSPSASASTSEASSASETNTTQTTSTPLPSPLGASQVMVTTPGLQTAAAALQGAAQLPANASLAAMAAAAGLSPGLMAPSQFAAGGALLSLSPGTLGSALSPALMSNSTLATIQALASSGSLPITSLDATGNLVFANAGGAPNIVTAPLFLNPQNLSLLTSNPVSLVSAAAASTGNSAPTASLHASSTSTESIQSSLFTVASASGPASTTTAASKAQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
8 (in isoform 12)Phosphorylation-37.8526643407
11 (in isoform 5)Phosphorylation-28.3329895711
11 (in isoform 4)Phosphorylation-28.3329895711
11 (in isoform 11)Phosphorylation-28.3329895711
12 (in isoform 12)Phosphorylation-9.4223984901
13 (in isoform 12)Phosphorylation-53.5823984901
17 (in isoform 5)Phosphorylation-12.6329895711
17 (in isoform 4)Phosphorylation-12.6329895711
17 (in isoform 11)Phosphorylation-12.6329895711
256PhosphorylationQPTTPTRTIAAASVQ
CCCCCCCEEEEEEEE		19.9025619855
264PhosphorylationIAAASVQTLPQSQST
EEEEEEECCCCCCCC		37.9525619855
268PhosphorylationSVQTLPQSQSTPKRI
EEECCCCCCCCCCCC		24.9425619855
270PhosphorylationQTLPQSQSTPKRIDT
ECCCCCCCCCCCCCC		52.5025619855
271PhosphorylationTLPQSQSTPKRIDTP
CCCCCCCCCCCCCCC		25.7825619855
277PhosphorylationSTPKRIDTPSLEEPS
CCCCCCCCCCCCCCC		16.6527180971
279PhosphorylationPKRIDTPSLEEPSDL
CCCCCCCCCCCCCCH		50.9726745281
284PhosphorylationTPSLEEPSDLEELEQ
CCCCCCCCCHHHHHH		59.09-
294 (in isoform 12)Ubiquitination-56.6422790023
294UbiquitinationEELEQFAKTFKQRRI
HHHHHHHHHHHHHHH		56.6422790023
325PhosphorylationYGNDFSQTTISRFEA
HCCCCCHHHHHHHHH		25.5423737553
326PhosphorylationGNDFSQTTISRFEAL
CCCCCHHHHHHHHHH		14.8723737553
328PhosphorylationDFSQTTISRFEALNL
CCCHHHHHHHHHHCC		28.9123737553
336PhosphorylationRFEALNLSFKNMCKL
HHHHHCCHHHHHHHC		32.8522006019
358PhosphorylationLNDAENLSSDSTASS
HHHHHHCCCCCCCCC		43.6226643407
359PhosphorylationNDAENLSSDSTASSP
HHHHHCCCCCCCCCH		38.4526643407
361PhosphorylationAENLSSDSTASSPSA
HHHCCCCCCCCCHHH		28.0226643407
362PhosphorylationENLSSDSTASSPSAL
HHCCCCCCCCCHHHH		35.2326643407
364PhosphorylationLSSDSTASSPSALNS
CCCCCCCCCHHHHCC		42.7626745281
365PhosphorylationSSDSTASSPSALNSP
CCCCCCCCHHHHCCC		22.0227087446
367PhosphorylationDSTASSPSALNSPGL
CCCCCCHHHHCCCCC		47.5427087446
371PhosphorylationSSPSALNSPGLGAEG
CCHHHHCCCCCCHHH		22.6126745281
387PhosphorylationNRRRKKRTSIETNIR
HHHHHCCCCHHHHHH		42.8326060331
388PhosphorylationRRRKKRTSIETNIRV
HHHHCCCCHHHHHHH		23.5924704852
391PhosphorylationKKRTSIETNIRVALE
HCCCCHHHHHHHHHH		33.9922345495
444PhosphorylationEKRINPPSSGGTSSS
CCCCCCCCCCCCCCC		42.7625619855
445PhosphorylationKRINPPSSGGTSSSP
CCCCCCCCCCCCCCC		47.1925619855
448PhosphorylationNPPSSGGTSSSPIKA
CCCCCCCCCCCCCCC		29.0323684622
449PhosphorylationPPSSGGTSSSPIKAI
CCCCCCCCCCCCCCC		31.9023684622
450PhosphorylationPSSGGTSSSPIKAIF
CCCCCCCCCCCCCCC		39.7223684622
451PhosphorylationSSGGTSSSPIKAIFP
CCCCCCCCCCCCCCC		30.3425521595
489PhosphorylationNPVLPLTSAAVTNLS
CCCCCCCCHHEECCC		23.16-
499 (in isoform 4)Phosphorylation-45.34-
505 (in isoform 2)Phosphorylation-11.90-
505 (in isoform 3)Phosphorylation-11.90-
517 (in isoform 5)Phosphorylation-26.24-
536PhosphorylationSNNNTATVISTAPPA
CCCCEEEEEECCCCC		2.7824719451
538PhosphorylationNNTATVISTAPPASS
CCEEEEEECCCCCHH		17.74-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PO2F1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PO2F1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PO2F1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PO2F1_MOUSEPou2f1physical
20211142
RPA1_MOUSEPolr1aphysical
20211142
PRDM5_MOUSEPrdm5physical
20211142
TLE4_MOUSETle4physical
16002402
AES_MOUSEAesphysical
16002402
MSX1_MOUSEMsx1physical
16002402
BRCA1_MOUSEBrca1physical
17700520
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PO2F1_MOUSE

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Related Literatures of Post-Translational Modification

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