dbPTM

PRDM5_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PRDM5_MOUSE
UniProt AC	Q9CXE0
Protein Name	PR domain zinc finger protein 5
Gene Name	Prdm5
Organism	Mus musculus (Mouse).
Sequence Length	599
Subcellular Localization	Nucleus.
Protein Description	Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. Regulates hematopoiesis-associated protein-coding and microRNA (miRNA) genes (By similarity). May regulate the expression of proteins involved in extracellular matrix development and maintenance, connective tissue components and molecules regulating cell migration and adhesion. May caused G2/M arrest and apoptosis in cancer cells (By similarity)..
Protein Sequence	MLGMYVPDRFALKSSRVQDGMGLYTARRVRKGEKFGPFAGEKRMPEDLDENMDYRLMWEVRGSKGEVLYILDATNPRHSNWLRFVHEAPSQERKNLAAIQEGENIFYLAVDDIETDTELLIGYLDSDVEAEEEEQQALTMTKEGKVDHSKGQLAAGSKGHLGCEEDFACPQCESSFPSEEVLTEHLQSLHQKPTGEKEFKCENCGKKFPVRQALQRHFEQHRKACRGEARFVCKADSCGKRLKSKDALRRHQENVHTGDPKRKLICSVCNRKCTSVSSLQEHRKIHEIFDCQECMKKFISANQLKRHMITHSEKRPYNCEICNKSFKRLDQVGAHKVIHSEDKPYQCKLCGKGFAHRNVYKNHKKTHSEERPFQCDACKALFRTPFSLQRHLLIHNSERTFKCHHCDATFKRKDTLNVHVQVVHERHKKYRCELCNKAFVTPSVLRSHKKTHTGEKEKVCPYCGQKFASSGTLRVHIRSHTGERPYQCPYCEKGFSKNDGLKMHIRTHTREKPYQCSECSKAFSQKRGLDEHKRTHTGEKPFQCDVCDLAFSLKKMLIRHKMTHNPNRPMAECHFCHKKFTRNDYLKVHMDNIHGVADS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
453	Phosphorylation	RSHKKTHTGEKEKVC HHCCCCCCCCCCEEC	52.87	28059163
599	Phosphorylation	NIHGVADS------- CCCCCCCC-------	32.17	25338131

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PRDM5_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PRDM5_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PRDM5_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of PRDM5_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PRDM5_MOUSE

Related Literatures of Post-Translational Modification