SIX3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SIX3_MOUSE
• UniProt AC: Q62233
• Protein Name: Homeobox protein SIX3
• Gene Name: Six3
• Organism: Mus musculus (Mouse).
• Sequence Length: 333
• Subcellular Localization: Nucleus .
• Protein Description: Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on these target genes. During forebrain development represses WNT1 expression allowing zona limitans intrathalamica formation and thereby ensuring proper anterio-posterior patterning of the diencephalon and formation of the rostral diencephalon. [PubMed: 18094027 Acts as a direct upstream activator of SHH expression in the rostral diencephalon ventral midline and that in turn SHH maintains its expression]
• Protein Sequence: MVFRSPLDLYSSHFLLPNFADSHHCSLLLASSGGGSGASGGGGGAGGGGGGNRAGGGGAGGAGGGSGGGGSRAPPEELSMFQLPTLNFSPEQVASVCETLEETGDIERLGRFLWSLPVAPGACEAINKHESILRARAVVAFHTGNFRDLYHILENHKFTKESHGKLQAMWLEAHYQEAEKLRGRPLGPVDKYRVRKKFPLPRTIWDGEQKTHCFKERTRSLLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQRDRAAAAKNRLQHQAIGPSGMRSLAEPGCPTHGSAESPSTAASPTTSVSSLTERADTGTSILSVTSSDSECDV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
66	Phosphorylation	AGGAGGGSGGGGSRA CCCCCCCCCCCCCCC	37.22	-
291	Phosphorylation	LAEPGCPTHGSAESP HCCCCCCCCCCCCCC	42.84	24759943
297	Phosphorylation	PTHGSAESPSTAASP CCCCCCCCCCCCCCC	24.70	24759943
303	Phosphorylation	ESPSTAASPTTSVSS CCCCCCCCCCCCHHH	21.95	21183079
307	Phosphorylation	TAASPTTSVSSLTER CCCCCCCCHHHHHHC	23.60	21183079
309	Phosphorylation	ASPTTSVSSLTERAD CCCCCCHHHHHHCCC	21.28	24759943
310	Phosphorylation	SPTTSVSSLTERADT CCCCCHHHHHHCCCC	36.84	24759943

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SIX3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SIX3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SIX3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AES_MOUSE	Aes	physical	12050133
GROU_DROME	gro	physical	12050133

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.