SIX6_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SIX6_MOUSE
• UniProt AC: Q9QZ28
• Protein Name: Homeobox protein SIX6
• Gene Name: Six6
• Organism: Mus musculus (Mouse).
• Sequence Length: 246
• Subcellular Localization: Nucleus .
• Protein Description: May be involved in eye development..
• Protein Sequence: MFQLPILNFSPQQVAGVCETLEESGDVERLGRFLWSLPVAPAACEALNKNESVLRARAIVAFHGGNYRELYHILENHKFTKESHAKLQALWLEAHYQEAEKLRGRPLGPVDKYRVRKKFPLPRTIWDGEQKTHCFKERTRHLLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQRDRAAAAKNRLQQQVLSQGPGRVLRSEGEGTPEVLGVASSPAASLSSKAATSAISITSSDSECDI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
212	Phosphorylation	LRSEGEGTPEVLGVA EECCCCCCCCCEEEE	16.39	-
221	Phosphorylation	EVLGVASSPAASLSS CCEEEECCCCHHCCC	14.60	-
225	Phosphorylation	VASSPAASLSSKAAT EECCCCHHCCCCCCC	30.78	-
227	Phosphorylation	SSPAASLSSKAATSA CCCCHHCCCCCCCCC	27.57	-
228	Phosphorylation	SPAASLSSKAATSAI CCCHHCCCCCCCCCC	31.44	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SIX6_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SIX6_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SIX6_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VAX2_MOUSE	Vax2	physical	20211142
TF2AY_MOUSE	Gtf2a1l	physical	20211142

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.