NFYB_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NFYB_HUMAN
• UniProt AC: P25208
• Protein Name: Nuclear transcription factor Y subunit beta
• Gene Name: NFYB
• Organism: Homo sapiens (Human).
• Sequence Length: 207
• Subcellular Localization: Nucleus.
• Protein Description: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors..
• Protein Sequence: MTMDGDSSTTDASQLGISADYIGGSHYVIQPHDDTEDSMNDHEDTNGSKESFREQDIYLPIANVARIMKNAIPQTGKIAKDAKECVQECVSEFISFITSEASERCHQEKRKTINGEDILFAMSTLGFDSYVEPLKLYLQKFREAMKGEKGIGGAVTATDGLSEELTEEAFTNQLPAGLITTDGQQQNVMVYTTSYQQISGVQQIQFS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTMDGDSST ------CCCCCCCCC	24.78	-
58	Phosphorylation	SFREQDIYLPIANVA HHHHCCCEECHHHHH	18.08	28674419
77	Ubiquitination	NAIPQTGKIAKDAKE HCCCCCCCHHHHHHH	42.76	-
112	Phosphorylation	CHQEKRKTINGEDIL HHHHHCCCCCHHHHH	24.57	-
140	Ubiquitination	PLKLYLQKFREAMKG HHHHHHHHHHHHHCC	43.74	21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NFYB_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
121	K	Methylation	Monoubiquitination at Lys-140 plays an important role in transcriptional activation by allowing the deposition of histone H3 methylations as well as histone H2B monoubiquitination at 'Lys-121'.	-
121	K	ubiquitylation	Monoubiquitination at Lys-140 plays an important role in transcriptional activation by allowing the deposition of histone H3 methylations as well as histone H2B monoubiquitination at 'Lys-121'.	-
140	K	Methylation	Monoubiquitination at Lys-140 plays an important role in transcriptional activation by allowing the deposition of histone H3 methylations as well as histone H2B monoubiquitination at 'Lys-121'.	23332751
140	K	ubiquitylation	Monoubiquitination at Lys-140 plays an important role in transcriptional activation by allowing the deposition of histone H3 methylations as well as histone H2B monoubiquitination at 'Lys-121'.	23332751

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NFYB_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NC2A_HUMAN	DRAP1	physical	16189514
MYC_HUMAN	MYC	physical	11282029
CEBPZ_HUMAN	CEBPZ	physical	11306579
P73_HUMAN	TP73	physical	12167641
TAF12_HUMAN	TAF12	physical	11689552
TAF11_HUMAN	TAF11	physical	11689552
TAF6_HUMAN	TAF6	physical	11689552
EP300_HUMAN	EP300	physical	15454570
P73_HUMAN	TP73	physical	15454570
KAT2B_HUMAN	KAT2B	physical	15454570
HDAC1_HUMAN	HDAC1	physical	20072153
SP1_HUMAN	SP1	physical	20072153
CDK2_HUMAN	CDK2	physical	12857729
CCNA2_HUMAN	CCNA2	physical	12857729
CCNE1_HUMAN	CCNE1	physical	12857729
NFYC_HUMAN	NFYC	physical	21988832
SMYD3_HUMAN	SMYD3	physical	21988832
NC2A_HUMAN	DRAP1	physical	25416956
DPOE4_HUMAN	POLE4	physical	25416956
ATRAP_HUMAN	AGTRAP	physical	25416956
COR1B_HUMAN	CORO1B	physical	26344197
LAGE3_HUMAN	LAGE3	physical	26344197
DPOE4_HUMAN	POLE4	physical	21516116
NFYA_HUMAN	NFYA	physical	26496610
NFYC_HUMAN	NFYC	physical	26496610

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.