dbPTM

SFSWA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SFSWA_HUMAN
UniProt AC	Q12872
Protein Name	Splicing factor, suppressor of white-apricot homolog
Gene Name	SFSWAP
Organism	Homo sapiens (Human).
Sequence Length	951
Subcellular Localization	Nucleus .
Protein Description	Plays a role as an alternative splicing regulator. Regulate its own expression at the level of RNA processing. Also regulates the splicing of fibronectin and CD45 genes. May act, at least in part, by interaction with other R/S-containing splicing factors. Represses the splicing of MAPT/Tau exon 10..
Protein Sequence	MYGASGGRAKPERKSGAKEEAGPGGAGGGGSRVELLVFGYACKLFRDDERALAQEQGQHLIPWMGDHKILIDRYDGRGHLHDLSEYDAEYSTWNRDYQLSEEEARIEALCDEERYLALHTDLLEEEARQEEEYKRLSEALAEDGSYNAVGFTYGSDYYDPSEPTEEEEPSKQREKNEAENLEENEEPFVAPLGLSVPSDVELPPTAKMHAIIERTASFVCRQGAQFEIMLKAKQARNSQFDFLRFDHYLNPYYKFIQKAMKEGRYTVLAENKSDEKKKSGVSSDNEDDDDEEDGNYLHPSLFASKKCNRLEELMKPLKVVDPDHPLAALVRKAQADSSTPTPHNADGAPVQPSQVEYTADSTVAAMYYSYYMLPDGTYCLAPPPPGIDVTTYYSTLPAGVTVSNSPGVTTTAPPPPGTTPLPPPTTAETSSGATSTTTTTSALAPVAAIIPPPPDVQPVIDKLAEYVARNGLKFETSVRAKNDQRFEFLQPWHQYNAYYEFKKQFFLQKEGGDSMQAVSAPEEAPTDSAPEKPSDAGEDGAPEDAAEVGARAGSGGKKEASSSKTVPDGKLVKASFAPISFAIKAKENDLLPLEKNRVKLDDDSDDDEESKEGQESSSSAANTNPAVAPPCVVVEEKKPQLTQEELEAKQAKQKLEDRLAAAAREKLAQASKESKEKQLQAERKRKAALFLQTLKNPLPEAEAGKIEESPFSVEESSTTPCPLLTGGRPLPTLEVKPPDRPSSKSKDPPREEEKEKKKKKHKKRSRTRSRSPKYHSSSKSRSRSHSKAKHSLPSAYRTVRRSRSRSRSPRRRAHSPERRREERSVPTAYRVSRSPGASRKRTRSRSPHEKKKKRRSRSRTKSKARSQSVSPSKQAAPRPAAPAAHSAHSASVSPVESRGSSQERSRGVSQEKEAQISSAIVSSVQSKITQDLMAKVRAMLAASKNLQTSAS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	RAKPERKSGAKEEAG CCCCCCCCCCCCCCC	50.64	21712546
18	Acetylation	PERKSGAKEEAGPGG CCCCCCCCCCCCCCC	60.66	26051181
90	Phosphorylation	LSEYDAEYSTWNRDY CHHHHHHHCCCCCCC	17.08	-
97	Phosphorylation	YSTWNRDYQLSEEEA HCCCCCCCCCCHHHH	14.23	27642862
100	Phosphorylation	WNRDYQLSEEEARIE CCCCCCCCHHHHHHH	27.69	-
133	Phosphorylation	EARQEEEYKRLSEAL HHHHHHHHHHHHHHH	12.51	28796482
157	Phosphorylation	GFTYGSDYYDPSEPT EEEECCCCCCCCCCC	16.09	-
164	Phosphorylation	YYDPSEPTEEEEPSK CCCCCCCCCCCCCHH	52.56	28787133
217	Phosphorylation	AIIERTASFVCRQGA HHHHHHHHHHHHCCC	20.01	24719451
238	Phosphorylation	KAKQARNSQFDFLRF EHHHHHHCCCCHHHH	27.03	21815630
248	Phosphorylation	DFLRFDHYLNPYYKF CHHHHHHHCCHHHHH	15.26	-
252	Phosphorylation	FDHYLNPYYKFIQKA HHHHCCHHHHHHHHH	20.43	-
253	Phosphorylation	DHYLNPYYKFIQKAM HHHCCHHHHHHHHHH	10.73	-
254	Acetylation	HYLNPYYKFIQKAMK HHCCHHHHHHHHHHH	30.10	26051181
273	Phosphorylation	TVLAENKSDEKKKSG EEEEECCCHHHHHCC	63.68	25849741
279	Phosphorylation	KSDEKKKSGVSSDNE CCHHHHHCCCCCCCC	53.99	22167270
282	Phosphorylation	EKKKSGVSSDNEDDD HHHHCCCCCCCCCCC	35.18	22167270
283	Phosphorylation	KKKSGVSSDNEDDDD HHHCCCCCCCCCCCC	41.89	22167270
296	Phosphorylation	DDEEDGNYLHPSLFA CCCCCCCCCCHHHHH	16.36	30266825
300	Phosphorylation	DGNYLHPSLFASKKC CCCCCCHHHHHCHHC	25.93	30266825
304	Phosphorylation	LHPSLFASKKCNRLE CCHHHHHCHHCCHHH	25.88	23403867
315	Acetylation	NRLEELMKPLKVVDP CHHHHHHCCCCCCCC	60.88	19608861
318	Ubiquitination	EELMKPLKVVDPDHP HHHHCCCCCCCCCCH	49.06	-
473	Ubiquitination	YVARNGLKFETSVRA HHHHCCCEEEEEECC	42.42	-
554	Phosphorylation	EVGARAGSGGKKEAS HHHHCCCCCCCCCCC	43.30	26074081
561	Phosphorylation	SGGKKEASSSKTVPD CCCCCCCCCCCCCCC	35.91	26546556
562	Phosphorylation	GGKKEASSSKTVPDG CCCCCCCCCCCCCCC	42.79	26546556
563	Phosphorylation	GKKEASSSKTVPDGK CCCCCCCCCCCCCCC	29.83	-
564	Acetylation	KKEASSSKTVPDGKL CCCCCCCCCCCCCCE	56.33	25953088
565	Phosphorylation	KEASSSKTVPDGKLV CCCCCCCCCCCCCEE	38.94	26546556
570	Acetylation	SKTVPDGKLVKASFA CCCCCCCCEEEEEEC	58.44	25953088
604	Phosphorylation	RVKLDDDSDDDEESK CCCCCCCCCCHHHHH	50.35	29255136
610	Phosphorylation	DSDDDEESKEGQESS CCCCHHHHHCHHHCC	33.68	30278072
616	Phosphorylation	ESKEGQESSSSAANT HHHCHHHCCCCCCCC	27.86	23927012
617	Phosphorylation	SKEGQESSSSAANTN HHCHHHCCCCCCCCC	27.79	30278072
618	Phosphorylation	KEGQESSSSAANTNP HCHHHCCCCCCCCCC	33.02	30278072
619	Phosphorylation	EGQESSSSAANTNPA CHHHCCCCCCCCCCC	33.09	30278072
623	Phosphorylation	SSSSAANTNPAVAPP CCCCCCCCCCCCCCC	37.54	30278072
642	Phosphorylation	EEKKPQLTQEELEAK ECCCCCCCHHHHHHH	28.78	17525332
649	Acetylation	TQEELEAKQAKQKLE CHHHHHHHHHHHHHH	41.22	18603005
693	Phosphorylation	KAALFLQTLKNPLPE HHHHHHHHHCCCCCH	41.67	20068231
709	Phosphorylation	EAGKIEESPFSVEES HCCCCCCCCCCCCCC	20.60	21406692
712	Phosphorylation	KIEESPFSVEESSTT CCCCCCCCCCCCCCC	31.81	27080861
716	Phosphorylation	SPFSVEESSTTPCPL CCCCCCCCCCCCCCC	21.34	27080861
717	Phosphorylation	PFSVEESSTTPCPLL CCCCCCCCCCCCCCC	39.31	26074081
718	Phosphorylation	FSVEESSTTPCPLLT CCCCCCCCCCCCCCC	44.00	27080861
719	Phosphorylation	SVEESSTTPCPLLTG CCCCCCCCCCCCCCC	25.49	26074081
725	Phosphorylation	TTPCPLLTGGRPLPT CCCCCCCCCCEECCC	45.32	27080861
732	Phosphorylation	TGGRPLPTLEVKPPD CCCEECCCCCCCCCC	43.14	30576142
742	Phosphorylation	VKPPDRPSSKSKDPP CCCCCCCCCCCCCCC	51.82	23401153
743	Phosphorylation	KPPDRPSSKSKDPPR CCCCCCCCCCCCCCH	43.56	29255136
769	Phosphorylation	KKRSRTRSRSPKYHS HHHHHHHCCCCCCCC	36.18	26657352
774	Phosphorylation	TRSRSPKYHSSSKSR HHCCCCCCCCCCCCC	15.43	-
778	Phosphorylation	SPKYHSSSKSRSRSH CCCCCCCCCCCCCCC	37.35	26657352
780	Phosphorylation	KYHSSSKSRSRSHSK CCCCCCCCCCCCCHH	37.12	26657352
786	Phosphorylation	KSRSRSHSKAKHSLP CCCCCCCHHHHHCHH	35.24	-
791	Phosphorylation	SHSKAKHSLPSAYRT CCHHHHHCHHHHHHH	41.07	28555341
794	Phosphorylation	KAKHSLPSAYRTVRR HHHHCHHHHHHHHHH	43.13	28555341
796	Phosphorylation	KHSLPSAYRTVRRSR HHCHHHHHHHHHHHH	15.91	-
802	Phosphorylation	AYRTVRRSRSRSRSP HHHHHHHHHHCCCCC	24.84	-
804	Phosphorylation	RTVRRSRSRSRSPRR HHHHHHHHCCCCCCH	35.54	22468782
805 (in isoform 2)	Phosphorylation	-	34.67	22985185
806	Phosphorylation	VRRSRSRSRSPRRRA HHHHHHCCCCCCHHC	38.05	20068231
807	Phosphorylation	RRSRSRSRSPRRRAH HHHHHCCCCCCHHCC	49.96	27251275
807 (in isoform 2)	Phosphorylation	-	49.96	30108239
808	Phosphorylation	RSRSRSRSPRRRAHS HHHHCCCCCCHHCCC	24.81	20068231
810 (in isoform 2)	Phosphorylation	-	41.80	27732954
815	Phosphorylation	SPRRRAHSPERRREE CCCHHCCCHHHHHHH	27.72	30576142
824	Phosphorylation	ERRREERSVPTAYRV HHHHHHCCCCCHHHH	35.41	23403867
827	Phosphorylation	REERSVPTAYRVSRS HHHCCCCCHHHHCCC	33.88	23403867
829	Phosphorylation	ERSVPTAYRVSRSPG HCCCCCHHHHCCCCC	17.64	23403867
832	Phosphorylation	VPTAYRVSRSPGASR CCCHHHHCCCCCCCC	20.31	23401153
834	Phosphorylation	TAYRVSRSPGASRKR CHHHHCCCCCCCCCC	21.85	23401153
838	Phosphorylation	VSRSPGASRKRTRSR HCCCCCCCCCCCCCC	44.22	23403867
844	Phosphorylation	ASRKRTRSRSPHEKK CCCCCCCCCCHHHHH	36.18	28176443
846	Phosphorylation	RKRTRSRSPHEKKKK CCCCCCCCHHHHHHH	31.67	28176443
862	Phosphorylation	RSRSRTKSKARSQSV HHHHHHHHHHHHHCC	30.82	20068231
866	Phosphorylation	RTKSKARSQSVSPSK HHHHHHHHHCCCCCC	31.50	28176443
868	Phosphorylation	KSKARSQSVSPSKQA HHHHHHHCCCCCCCC	26.30	28176443
870	Phosphorylation	KARSQSVSPSKQAAP HHHHHCCCCCCCCCC	28.80	28176443
872	Phosphorylation	RSQSVSPSKQAAPRP HHHCCCCCCCCCCCC	29.87	28176443
876	Phosphorylation	VSPSKQAAPRPAAPA CCCCCCCCCCCCCCC	9.72	27251275
884	Phosphorylation	PRPAAPAAHSAHSAS CCCCCCCCHHCCCCC	8.98	27251275
886	Phosphorylation	PAAPAAHSAHSASVS CCCCCCHHCCCCCCC	23.97	23898821
889	Phosphorylation	PAAHSAHSASVSPVE CCCHHCCCCCCCCCC	23.19	23401153
891	Phosphorylation	AHSAHSASVSPVESR CHHCCCCCCCCCCCC	26.58	29255136
893	Phosphorylation	SAHSASVSPVESRGS HCCCCCCCCCCCCCC	22.26	23401153
897	Phosphorylation	ASVSPVESRGSSQER CCCCCCCCCCCHHHH	42.02	29255136
900	Phosphorylation	SPVESRGSSQERSRG CCCCCCCCHHHHHCC	27.95	25159151
901	Phosphorylation	PVESRGSSQERSRGV CCCCCCCHHHHHCCC	38.59	21082442
905	Phosphorylation	RGSSQERSRGVSQEK CCCHHHHHCCCCHHH	32.41	30108239
909	Phosphorylation	QERSRGVSQEKEAQI HHHHCCCCHHHHHHH	35.13	22167270
917	Phosphorylation	QEKEAQISSAIVSSV HHHHHHHHHHHHHHH	11.13	30278072
918	Phosphorylation	EKEAQISSAIVSSVQ HHHHHHHHHHHHHHH	24.52	30278072
922	Phosphorylation	QISSAIVSSVQSKIT HHHHHHHHHHHHHHH	20.76	28302921
923	Phosphorylation	ISSAIVSSVQSKITQ HHHHHHHHHHHHHHH	17.18	23927012
926	Phosphorylation	AIVSSVQSKITQDLM HHHHHHHHHHHHHHH	24.70	28111955
927	Ubiquitination	IVSSVQSKITQDLMA HHHHHHHHHHHHHHH	32.45	-
935	Acetylation	ITQDLMAKVRAMLAA HHHHHHHHHHHHHHH	20.49	23954790
935	Ubiquitination	ITQDLMAKVRAMLAA HHHHHHHHHHHHHHH	20.49	-
941	Phosphorylation	AKVRAMLAASKNLQT HHHHHHHHHHHHHCC	9.15	27251275
943	Phosphorylation	VRAMLAASKNLQTSA HHHHHHHHHHHCCCC	19.23	27251275
944	Ubiquitination	RAMLAASKNLQTSAS HHHHHHHHHHCCCCC	57.88	-
945	Phosphorylation	AMLAASKNLQTSAS- HHHHHHHHHCCCCC-	34.58	27251275
961	Phosphorylation	----------------- -----------------		27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SFSWA_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SFSWA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SFSWA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of SFSWA_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SFSWA_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-315, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-283 AND SER-909, ANDMASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-282 AND SER-283, ANDMASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-283; SER-604 ANDSER-909, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry."; Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.; Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-604, AND MASSSPECTROMETRY.	17287340 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-604 AND SER-834, ANDMASS SPECTROMETRY.	17081983 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-834; SER-866 ANDSER-870, AND MASS SPECTROMETRY.	15302935 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-642, AND MASSSPECTROMETRY.	17525332 [Abstract]