TAF7L_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TAF7L_MOUSE
• UniProt AC: Q9D3R9
• Protein Name: Transcription initiation factor TFIID subunit 7-like
• Gene Name: Taf7l
• Organism: Mus musculus (Mouse).
• Sequence Length: 471
• Subcellular Localization: Nucleus. Cytoplasm. Cytoplasmic in spermatogonia and early spermatocytes (preleptotene, leptotene, and zygotene); translocates into the nuclei of pachytene spermatocytes and round spermatids.
• Protein Description: Probably functions as a spermatogensis-specific component of the DNA-binding general transcription factor complex TFIID, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. May play a role in spermatogenesis..
• Protein Sequence: MERGEEAPTEGAPPEGALVEAKAPVIPEAPATDVSTTEEAGSKEPQVPSGPRPEGAGDTCDTRGARGPPTPGRAKSQKTPRQGTARCQTLESAMRSMSVRLECHDVEEQFILRLPPEQAYAVRKIIHSRNAAWKDKLKIDFSPDGHHAVVQVDNVSLPAKLVNLPCVIGSLKTIDRKTFYKTADVSQMLVCSPEGEPHSPPEEPVVSTGPTVIGISEGKAERKKYNWKHGITPPLKNVRKKRFRKTTKKLPDVKQVDEINFSEYTQSPSVEKEVKRLLYSDAEAVSVRWEVVDDDDAKEIESQGSMPTTPGISQMGGASLSDYDVFREMMGDSGSNSNDVEEKSNEGDDDDDEDEDDEDYGNEKEEEETDNSEEELEKELQAKFNEFSLHEADQDYSSITMAIQKLIFIKEKRLQMIYKKAQRQKELLRKVENLTLKRHFQNVLGKLNIMEKEKCEQIYHLQEQLKCFLKE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
75	Acetylation	PPTPGRAKSQKTPRQ CCCCCCCCCCCCCCC	52.65	22902405
78	Acetylation	PGRAKSQKTPRQGTA CCCCCCCCCCCCCCH	68.53	22902405
89	Phosphorylation	QGTARCQTLESAMRS CCCHHHHHHHHHHHH	35.80	26745281
92	Phosphorylation	ARCQTLESAMRSMSV HHHHHHHHHHHHCCE	30.40	26745281
96	Phosphorylation	TLESAMRSMSVRLEC HHHHHHHHCCEEEEE	11.43	26745281
98	Phosphorylation	ESAMRSMSVRLECHD HHHHHHCCEEEEEEC	12.82	26745281
182	Phosphorylation	DRKTFYKTADVSQML CCCCCCCCCCHHHEE	19.40	25293948
186	Phosphorylation	FYKTADVSQMLVCSP CCCCCCHHHEEEECC	15.49	25293948
192	Phosphorylation	VSQMLVCSPEGEPHS HHHEEEECCCCCCCC	20.64	25293948
199	Phosphorylation	SPEGEPHSPPEEPVV CCCCCCCCCCCCCCC	53.52	22817900
207	Phosphorylation	PPEEPVVSTGPTVIG CCCCCCCCCCCEEEE	28.07	25293948
208	Phosphorylation	PEEPVVSTGPTVIGI CCCCCCCCCCEEEEE	35.25	25293948
228	Acetylation	ERKKYNWKHGITPPL HHHHCCCCCCCCCCH	28.45	19851175
232	Phosphorylation	YNWKHGITPPLKNVR CCCCCCCCCCHHHHH	24.36	21183079
264	Phosphorylation	DEINFSEYTQSPSVE CCCCHHHCCCCCHHH	14.64	25293948
265	Phosphorylation	EINFSEYTQSPSVEK CCCHHHCCCCCHHHH	20.65	25293948
267	Phosphorylation	NFSEYTQSPSVEKEV CHHHCCCCCHHHHHH	16.02	25293948
269	Phosphorylation	SEYTQSPSVEKEVKR HHCCCCCHHHHHHHH	48.43	25293948
279	Phosphorylation	KEVKRLLYSDAEAVS HHHHHHHHCCCCEEE	14.75	-
286	Phosphorylation	YSDAEAVSVRWEVVD HCCCCEEEEEEEEEC	17.02	-
333	Phosphorylation	FREMMGDSGSNSNDV HHHHHCCCCCCCCCC	38.09	-
335	Phosphorylation	EMMGDSGSNSNDVEE HHHCCCCCCCCCCHH	40.82	-
337	Phosphorylation	MGDSGSNSNDVEEKS HCCCCCCCCCCHHHH	35.78	-
360	Phosphorylation	EDEDDEDYGNEKEEE CCCCCCCCCCHHHHH	21.58	21183079
369	Phosphorylation	NEKEEEETDNSEEEL CHHHHHHCCCCHHHH	43.70	21183079
372	Phosphorylation	EEEETDNSEEELEKE HHHHCCCCHHHHHHH	49.55	21183079
420	Succinylation	RLQMIYKKAQRQKEL HHHHHHHHHHHHHHH	32.55	24315375

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TAF7L_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TAF7L_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TAF7L_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of TAF7L_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.