TF2B_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TF2B_MOUSE
• UniProt AC: P62915
• Protein Name: Transcription initiation factor IIB
• Gene Name: Gtf2b
• Organism: Mus musculus (Mouse).
• Sequence Length: 316
• Subcellular Localization: Nucleus.
• Protein Description: General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II..
• Protein Sequence: MASTSRLDALPRVTCPNHPDAILVEDYRAGDMICPECGLVVGDRVIDVGSEWRTFSNDKATKDPSRVGDSQNPLLSDGDLSTMIGKGTGAASFDEFGNSKYQNRRTMSSSDRAMMNAFKEITTMADRINLPRNIVDRTNNLFKQVYEQKSLKGRANDAIASACLYIACRQEGVPRTFKEICAVSRISKKEIGRCFKLILKALETSVDLITTGDFMSRFCSNLCLPKQVQMAATHIARKAVELDLVPGRSPISVAAAAIYMASQASAEKRTQKEIGDIAGVADVTIRQSYRLIYPRAPDLFPSDFKFDTPVDKLPQL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MASTSRLDAL -----CCCCCCCCCC	26.14	26745281
4	Phosphorylation	----MASTSRLDALP ----CCCCCCCCCCC	14.34	26745281
5	Phosphorylation	---MASTSRLDALPR ---CCCCCCCCCCCC	28.49	26745281
70	Phosphorylation	DPSRVGDSQNPLLSD CHHHCCCCCCCCCCC	26.40	23984901
76	Phosphorylation	DSQNPLLSDGDLSTM CCCCCCCCCCCHHHH	47.43	27087446
81	Phosphorylation	LLSDGDLSTMIGKGT CCCCCCHHHHCCCCC	22.22	26745281
82	Phosphorylation	LSDGDLSTMIGKGTG CCCCCHHHHCCCCCC	21.80	26745281
88	Phosphorylation	STMIGKGTGAASFDE HHHCCCCCCCCCHHH	27.42	29899451
92	Phosphorylation	GKGTGAASFDEFGNS CCCCCCCCHHHCCCC	32.47	26643407
100	Ubiquitination	FDEFGNSKYQNRRTM HHHCCCCHHCCCCCC	55.65	-
119	Ubiquitination	RAMMNAFKEITTMAD HHHHHHHHHHHHHHH	45.88	22790023
178	Acetylation	EGVPRTFKEICAVSR CCCCCCHHHHHHHHC	45.62	22826441
238	Acetylation	AATHIARKAVELDLV HHHHHHHHHHHCCCC	48.00	-
249	Phosphorylation	LDLVPGRSPISVAAA CCCCCCCCHHHHHHH	32.28	26745281
252	Phosphorylation	VPGRSPISVAAAAIY CCCCCHHHHHHHHHH	14.75	26745281

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TF2B_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
238	K	Acetylation	Autoacetylated; autoacetylation at Lys-238 stimulates transcription activation.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TF2B_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
T2FA_HUMAN	GTF2F1	physical	26496610
T2FB_HUMAN	GTF2F2	physical	26496610
RPB1_HUMAN	POLR2A	physical	26496610
RPB2_HUMAN	POLR2B	physical	26496610
RPB3_HUMAN	POLR2C	physical	26496610
RPB9_HUMAN	POLR2I	physical	26496610
RPB11_HUMAN	POLR2J	physical	26496610
UBL4A_HUMAN	UBL4A	physical	26496610
CTDP1_HUMAN	CTDP1	physical	26496610
EFR3A_HUMAN	EFR3A	physical	26496610
CDK12_HUMAN	CDK12	physical	26496610
4ET_HUMAN	EIF4ENIF1	physical	26496610
CHD8_HUMAN	CHD8	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.