| UniProt ID | TAF1A_MOUSE | |
|---|---|---|
| UniProt AC | P97357 | |
| Protein Name | TATA box-binding protein-associated factor RNA polymerase I subunit A | |
| Gene Name | Taf1a | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 453 | |
| Subcellular Localization | Nucleus. | |
| Protein Description | Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits (By similarity).. | |
| Protein Sequence | MMSDFGEELTKLAVAEDNPETSVLSKTGMHFPWLHKHVEAVVTGGKKRKDFAQTTSACLSFIQEALLKHQWQQAAEYMHSYLQTLEDSDTDKRQAAPEIIWKLGSEILFYHPKSNVETFNSFADRMKNIGVLNYLKISLQHALYLLHHGMLDDANRNLSKAETWRYGEKSSSQEVLINLVQAYKGLLQYYTWTRKKMELSKLDEDDYAYAAKTRTMLSQSCKTSTNICALVKTPGVWDPFVKSYVEMLEFYGDQDGAREMLTNYAYDEKFPSNPNAHVYLYEFLKREKAPRAKLISVLKILHEIVPSHTLMLEFHTLLRKSDTEEHQKLGLSVLFEVLDFAGCNKNITAWKYLAKYLKQILVGSHHEWVEEEWKSRRNWWPAFHFSFFWAKSDWKADTDLACEKAFVAGVLLGKGCKYFRYILKQDHETLKKKIKRMKKSVKKYTIVNPGVHT | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | Phosphorylation | -----MMSDFGEELT -----CCCCHHHHHH | 28.61 | 29514104 | |
| 105 | Phosphorylation | EIIWKLGSEILFYHP HHHHHHCCEEEEECC | 31.72 | - | |
| 110 | Phosphorylation | LGSEILFYHPKSNVE HCCEEEEECCCCCHH | 17.48 | - | |
| 121 | Phosphorylation | SNVETFNSFADRMKN CCHHHHHHHHHHHHH | 20.02 | 29899451 | |
| 251 | Phosphorylation | YVEMLEFYGDQDGAR HHHHHHHHCCCCHHH | 15.49 | - | |
| 264 | Phosphorylation | AREMLTNYAYDEKFP HHHHHHHHHCCCCCC | 10.99 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TAF1A_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TAF1A_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TAF1A_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| TBP_MOUSE | Tbp | physical | 20211142 | |
| TBP_MOUSE | Tbp | physical | 9050847 | |
| TAF1B_MOUSE | Taf1b | physical | 9050847 | |
| TAF1C_MOUSE | Taf1c | physical | 9050847 | |
| TBP_HUMAN | TBP | physical | 9050847 | |
| TAF1B_HUMAN | TAF1B | physical | 9050847 | |
| TAF1C_HUMAN | TAF1C | physical | 9050847 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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