TAF1B_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TAF1B_MOUSE
• UniProt AC: P97358
• Protein Name: TATA box-binding protein-associated factor RNA polymerase I subunit B
• Gene Name: Taf1b
• Organism: Mus musculus (Mouse).
• Sequence Length: 586
• Subcellular Localization: Nucleus, nucleolus.
• Protein Description: Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3..
• Protein Sequence: MDVEEVKAFRDRCSQCAAVSWGLTDEGKYYCTSCHNVTDRSEEVVSAADIPNTKINSINRGLRQRSKHEKGWDWYVCEGFQCILYHQAKALETLGVSPELKNEVLHNFWKRYLQKSKQAYCKNPVRTSGRKAKVLEDSVQSSDLGSDLELLSDTTCPLESEAEFQSDPQIPKPFPVTKGSPKSASVCSGSVDGVEYSERKEKGLVKMTVPRTLALCSLSLLWQRETITVSDLLRFVEEDHIPYINAFKLFPEEMKVYGRDKGIFAIESWPDYEDIYKNMIELAIFLDLPRFPDITEDCYLHPNTLCMKYLLEVNLPDEMHTLTCQVVKLTGIGEVDFLTFDPIAKTKRTVKYDVQAMAVIVVVLKLLFLLDDKLEWSYSDLAEAYNEQHREDTPQFDFRKWYQVMKKTFDEKRRKWEEARARYAWKTKRPLYRSHIDKSVAYKRRKMVENLQKQFSALVGSSPVVEKQAPSSFQFNWTEEGTDSPCFHGHSLQGLLIMKGQSMITKNSLYWLSTQKFCKSYCKHVTTYEESNFSLSYQFILNIFSFLLRIKTSALHEEVSLLEKKLFEKKYNESKKSSGSKKGRRH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDVEEVKA -------CCHHHHHH	13.54	-
202	Acetylation	EYSERKEKGLVKMTV CCCHHHHCCCEEECH	61.66	15608947
206	Acetylation	RKEKGLVKMTVPRTL HHHCCCEEECHHHHH	33.62	15608955
438	Acetylation	LYRSHIDKSVAYKRR HHHHCCCHHHHHHHH	46.34	-
461	Phosphorylation	QFSALVGSSPVVEKQ HHHHHHCCCCCCCCC	24.80	28066266
462	Phosphorylation	FSALVGSSPVVEKQA HHHHHCCCCCCCCCC	18.78	28066266
526	Phosphorylation	KSYCKHVTTYEESNF HHHCCCCCCCCCCCC	24.31	25367039
527	Phosphorylation	SYCKHVTTYEESNFS HHCCCCCCCCCCCCC	28.04	25367039
528	Phosphorylation	YCKHVTTYEESNFSL HCCCCCCCCCCCCCH	14.34	25367039
531	Phosphorylation	HVTTYEESNFSLSYQ CCCCCCCCCCCHHHH	31.10	25367039
534	Phosphorylation	TYEESNFSLSYQFIL CCCCCCCCHHHHHHH	22.21	25367039
536	Phosphorylation	EESNFSLSYQFILNI CCCCCCHHHHHHHHH	18.71	25367039
537	Phosphorylation	ESNFSLSYQFILNIF CCCCCHHHHHHHHHH	16.85	25367039
545	Phosphorylation	QFILNIFSFLLRIKT HHHHHHHHHHHHHHH	15.93	25367039

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TAF1B_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TAF1B_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TAF1B_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TBP_MOUSE	Tbp	physical	20211142
TFE2_MOUSE	Tcf3	physical	20211142
TBP_MOUSE	Tbp	physical	9050847
TAF1A_MOUSE	Taf1a	physical	9050847
TAF1C_MOUSE	Taf1c	physical	9050847
TBP_HUMAN	TBP	physical	9050847
TAF1A_HUMAN	TAF1A	physical	9050847
TAF1C_HUMAN	TAF1C	physical	9050847

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.