| UniProt ID | TAF1C_MOUSE | |
|---|---|---|
| UniProt AC | Q6PDZ2 | |
| Protein Name | TATA box-binding protein-associated factor RNA polymerase I subunit C | |
| Gene Name | Taf1c | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 836 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3 (By similarity).. | |
| Protein Sequence | MDFPGTLRPSLFKAGPLGMTDGPDLSFMCSWRDALTLPGSQPQNCKDPTLSFAKNLLWEPSTPGPLPLLMPPDPDPWDPGVTAQDFLFRGGHCYQYQSQAVLDVTEQLSRFLWDHGDIAFAPLGRLMLENFRLEGNRGYSKKMTIVSAKKLLQDLGGHQPWGCPWASLSRRLRRFSIVGGPVLSRSVSLLMGKLLHEELAMRWEQLLMDEAFTGGALAWLPGRTARAGQLVYPSGGALDKLYFQEVSVTSGGNPRILENPGHVQLRGPVRQVVTSTVQGETLLAVRSDYHCATWKIDKQGPPALLQVMQVEKGATGISLSPHLSGELAICSRSGAVCLWTPQAGLQTIYKDTETLAFRDPSPWRWADFTAHPRVLTVGDRTGVKMVDIQGPPGCGLLLFRAGAEAACQKGERVLLAQYLGQPGQTPPSLHLICTQFSIYLMDERLPLVPMLKWDHGLPSAPLLARLLPPASPGHPRPLLLGGQGGQLQLLHITGEGTSMPQLAGPPQSLPSITESLSAFPLLEPKKQQLLQERLEAPVIGLAAVPLCASAPGLLLFQLSAAGDVFYQHLRLLQASSPRKVPEQATAPSVDQVSTPSWTPQASARCSRWLEDLMELSPTRPLWVAPTFSHRRFLGHMERQKSQETMPQKLRAAMAKGQLLRPGDLSTLPRAEPPPAPQCSQQDELTERLTEAWEGRVTAWWRRHRGETSETQTQSKRPKRRTQLSSTFSSFTSYLDSPDASSAPRSQDLSTSEARLQSPRVPPSQELTQEVWGQGVKRERRQTLRDHTDKLPLKRDTPGPVATPPSQASSLQTMSFRQQTPVHSGSQPPQKKPRMGF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 361 | Phosphorylation | TLAFRDPSPWRWADF EEECCCCCCCCCCCC | 41.19 | 22982522 | |
| 575 | Phosphorylation | HLRLLQASSPRKVPE HHHHHHCCCCCCCCC | 28.10 | 26824392 | |
| 576 | Phosphorylation | LRLLQASSPRKVPEQ HHHHHCCCCCCCCCC | 31.57 | 26824392 | |
| 679 | Phosphorylation | PPPAPQCSQQDELTE CCCCCCCCCCHHHHH | 26.15 | 28285833 | |
| 763 | Phosphorylation | QSPRVPPSQELTQEV CCCCCCCCHHHHHHH | 30.16 | 22006019 | |
| 802 | Phosphorylation | DTPGPVATPPSQASS CCCCCCCCCHHHCCC | 35.65 | 22006019 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TAF1C_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TAF1C_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TAF1C_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| TBP_MOUSE | Tbp | physical | 20211142 | |
| TBP_MOUSE | Tbp | physical | 9050847 | |
| TAF1A_MOUSE | Taf1a | physical | 9050847 | |
| TAF1B_MOUSE | Taf1b | physical | 9050847 | |
| TBP_HUMAN | TBP | physical | 9050847 | |
| TAF1A_HUMAN | TAF1A | physical | 9050847 | |
| TAF1B_HUMAN | TAF1B | physical | 9050847 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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