TF2AA_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TF2AA_MOUSE
• UniProt AC: Q99PM3
• Protein Name: Transcription initiation factor IIA subunit 1
• Gene Name: Gtf2a1
• Organism: Mus musculus (Mouse).
• Sequence Length: 378
• Subcellular Localization: Nucleus.
• Protein Description: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity (By similarity)..
• Protein Sequence: MANSANTNTVPKLYRSVIEDVINDVRDIFLDDGVDEQVLMELKTLWENKLMQSRAVDGFHSEEQQLLLQVQQQHQPQQQQHHHHHHQHQQAQPQQTVPQQAQTQQVLIPASQQATAPQVIVPDSKLLQHMNASSITSAAATAATLALPAGVTPVQQLLTNSGQLLQVVRAANGAQYILQPQQSVVLQQQVIPQMQPGGVQAPVIQQVLAPLPGGISPQTGVIIQPQQILFTGNKTQVIPTTVAAPAPAQAPMPAAGQQQPQAQPAQQQAPLVLQVDGTGDTSSEEDEDEEEDYDDDEEEDKEKDGAEDGQVEEEPLNSEDDVSDEEGQELFDTENVVVCQYDKIHRSKNKWKFHLKDGIMNLNGRDYIFSKAIGDAEW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MANSANTNT ------CCCCCCCCH	20.77	-
282	Phosphorylation	VDGTGDTSSEEDEDE ECCCCCCCCCCCCCC	40.26	-
283	Phosphorylation	DGTGDTSSEEDEDEE CCCCCCCCCCCCCCC	47.28	-
318	Phosphorylation	VEEEPLNSEDDVSDE CCCCCCCCCCCCCHH	50.51	26525534
323	Phosphorylation	LNSEDDVSDEEGQEL CCCCCCCCHHHHHCH	46.42	26525534
333	Phosphorylation	EGQELFDTENVVVCQ HHHCHHCCCCEEEEE	23.33	26525534

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
282	S	Phosphorylation	Kinase	TAF1	Q80UV9	Uniprot
283	S	Phosphorylation	Kinase	TAF1	Q80UV9	Uniprot
318	S	Phosphorylation	Kinase	TAF1	Q80UV9	Uniprot
323	S	Phosphorylation	Kinase	TAF1	Q80UV9	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TF2AA_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TF2AA_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SNPC4_MOUSE	Snapc4	physical	20211142

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.