SNPC4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SNPC4_MOUSE
• UniProt AC: Q8BP86
• Protein Name: snRNA-activating protein complex subunit 4
• Gene Name: Snapc4 {ECO:0000312|MGI:MGI:2443935}
• Organism: Mus musculus (Mouse).
• Sequence Length: 1333
• Subcellular Localization: Nucleus .
• Protein Description: Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box (By similarity)..
• Protein Sequence: MDIDAEREKITQEIQELERILYPGSTSVHFEVSESSLSSDSEADSLPDEDLETAGAPILEEEGSSESSNDEEDPKDKALPEDPETCLQLNMVYQEVIREKLAEVSQLLAQNQEQQEEILFDLSGTKCPKVKDGRSLPSYMYIGHFLKPYFKDKVTGVGPPANEETREKATQGIKAFEQLLVTKWKHWEKALLRKSVVSDRLQRLLQPKLLKLEYLHEKQSRVSSELERQALEKQIKEAEKEIQDINQLPEEALLGNRLDSHDWEKISNINFEGARSAEEIRKFWQSSEHPSISKQEWSTEEVERLKAIAATHGHLEWHLVAEELGTSRSAFQCLQKFQQYNKTLKRKEWTEEEDHMLTQLVQEMRVGNHIPYRKIVYFMEGRDSMQLIYRWTKSLDPSLKRGFWAPEEDAKLLQAVAKYGAQDWFKIREEVPGRSDAQCRDRYIRRLHFSLKKGRWNAKEEQQLIQLIEKYGVGHWARIASELPHRSGSQCLSKWKILARKKQHLQRKRGQRPRHSSQWSSSGSSSSSSEDYGSSSGSDGSSGSENSDVELEASLEKSRALTPQQYRVPDIDLWVPTRLITSQSQREGTGCYPQHPAVSCCTQDASQNHHKEGSTTVSAAEKNQLQVPYETHSTVPRGDRFLHFSDTHSASLKDPACKSHTLMKERPKQPLLPSSRSGSDPGNNTAGPHLRQLWHGTYQNKQRRKRQALHRRLLKHRLLLAVIPWVGDINLACTQAPRRPATVQTKADSIRMQLECARLASTPVFTLLIQLLQIDTAGCMEVVRERKSQPPALLQPGTRNTQPHLLQASSNAKNNTGCLPSMTGEQTAKRASHKGRPRLGSCRTEATPFQVPVAAPRGLRPKPKTVSELLREKRLRESHAKKATQALGLNSQLLVSSPVILQPPLLPVPHGSPVVGPATSSVELSVPVAPVMVSSSPSGSWPVGGISATDKQPPNLQTISLNPPHKGTQVAAPAAFRSLALAPGQVPTGGHLSTLGQTSTTSQKQSLPKVLPILRAAPSLTQLSVQPPVSGQPLATKSSLPVNWVLTTQKLLSVQVPAVVGLPQSVMTPETIGLQAKQLPSPAKTPAFLEQPPASTDTEPKGPQGQEIPPTPGPEKAALDLSLLSQESEAAIVTWLKGCQGAFVPPLGSRMPYHPPSLCSLRALSSLLLQKQDLEQKASSLAASQAAGAQPDPKAGALQASLELVQRQFRDNPAYLLLKTRFLAIFSLPAFLATLPPNSIPTTLSPDVAVVSESDSEDLGDLELKDRARQLDCMACRVQASPAAPDPVQSHLVSPGQRAPSPGEVSAPSPLDASDGLDDLNVLRTRRARHSRR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
68	Phosphorylation	EEGSSESSNDEEDPK CCCCCCCCCCCCCCC	44.22	-
389	Phosphorylation	RDSMQLIYRWTKSLD CCHHHHHHHHHHCCC	14.53	25521595
558	Phosphorylation	LEASLEKSRALTPQQ HHHHHHHHHCCCCCH	17.26	28059163
562	Phosphorylation	LEKSRALTPQQYRVP HHHHHCCCCCHHCCC	20.33	28833060
664	Acetylation	CKSHTLMKERPKQPL HHCCCCCCCCCCCCC	54.40	7721313
841	Phosphorylation	KGRPRLGSCRTEATP CCCCCCCCCCCCCCC	12.67	25266776
1179	Phosphorylation	QDLEQKASSLAASQA CCHHHHHHHHHHHHH	32.68	24719451
1180	Phosphorylation	DLEQKASSLAASQAA CHHHHHHHHHHHHHH	27.21	24719451
1191 (in isoform 3)	Phosphorylation	-	60.38	28066266
1203 (in isoform 3)	Phosphorylation	-	44.38	22817900
1211 (in isoform 3)	Phosphorylation	-	67.75	29514104
1252	Phosphorylation	SPDVAVVSESDSEDL CCCEEEECCCCCCCC	25.45	-
1254	Phosphorylation	DVAVVSESDSEDLGD CEEEECCCCCCCCCC	38.64	-
1281 (in isoform 2)	Phosphorylation	-	9.66	28066266
1293 (in isoform 2)	Phosphorylation	-	5.63	22817900
1301 (in isoform 2)	Phosphorylation	-	44.55	29514104
1301	Phosphorylation	SPGQRAPSPGEVSAP CCCCCCCCCCCCCCC	44.55	26824392
1306	Phosphorylation	APSPGEVSAPSPLDA CCCCCCCCCCCCCCC	30.11	25619855
1309	Phosphorylation	PGEVSAPSPLDASDG CCCCCCCCCCCCCCC	37.50	25619855
1314	Phosphorylation	APSPLDASDGLDDLN CCCCCCCCCCCCHHH	31.70	25619855

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SNPC4_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SNPC4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SNPC4_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SNPC4_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.