PIAS3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PIAS3_MOUSE
• UniProt AC: O54714
• Protein Name: E3 SUMO-protein ligase PIAS3
• Gene Name: Pias3
• Organism: Mus musculus (Mouse).
• Sequence Length: 628
• Subcellular Localization: Cytoplasm . Nucleus . Nucleus speckle . Colocalizes with MITF in the nucleus (PubMed:11709556). Colocalizes with GFI1 in nuclear dots (PubMed:11060035). Colocalizes with SUMO1 in nuclear granules (PubMed:12077349).
• Protein Description: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Repressor of STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Repressor of MITF transcriptional activity. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. Sumoylates CCAR2 which promotes its interaction with SIRT1 (By similarity). Diminishes the sumoylation of ZFHX3 by preventing the colocalization of ZFHX3 with SUMO1 in the nucleus (By similarity)..
• Protein Sequence: MAELGELKHMVMSFRVSELQVLLGFAGRNKSGRKHELLAKALHLLKSSCAPSVQMKIKELYRRRFPRKTLGPSDLSLLSLPPGTSPVGSPGPLAPIPPTLLTPGTLLGPKREVDMHPPLPQPVHPDVTMKPLPFYEVYGELIRPTTLASTSSQRFEEAHFTFALTPQQLQQILTSREVLPGAKCDYTIQVQLRFCLCETSCPQEDYFPPNLFVKVNGKLCPLPGYLPPTKNGAEPKRPSRPINITPLARLSATVPNTIVVNWSSEFGRNYSLSVYLVRQLTAGTLLQKLRAKGIRNPDHSRALIKEKLTADPDSEVATTSLRVSLMCPLGKMRLTVPCRALTCAHLQSFDAALYLQMNEKKPTWTCPVCDKKAPYESLIIDGLFMEILNSCSDCDEIQFMEDGSWCPMKPKKEASEVCPPPGYGLDGLQYSAVQEGIQPESKKRVEVIDLTIESSSDEEDLPPTKKHCPVTSAAIPALPGSKGALTSGHQPSSVLRSPAMGTLGSDFLSSLPLHEYPPAFPLGADIQGLDLFSFLQTESQHYGPSVITSLDEQDTLGHFFQYRGTPSHFLGPLAPTLGSSHRSSTPAPPPGRVSSIVAPGSSLREGHGGPLPSGPSLTGCRSDVISLD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAELGELKH ------CCCHHHHHH	22.26	-
295	Asymmetric dimethylarginine	KLRAKGIRNPDHSRA HHHHCCCCCCHHHHH	58.24	-
404	Phosphorylation	IQFMEDGSWCPMKPK EEECCCCCCCCCCCC	37.51	-
423	Phosphorylation	EVCPPPGYGLDGLQY CCCCCCCCCCCCHHH	21.93	29514104
430	Phosphorylation	YGLDGLQYSAVQEGI CCCCCHHHHHHHCCC	12.02	29514104
454	Phosphorylation	VIDLTIESSSDEEDL EEEEEECCCCCCCCC	31.15	22817900
455	Phosphorylation	IDLTIESSSDEEDLP EEEEECCCCCCCCCC	29.08	-
456	Phosphorylation	DLTIESSSDEEDLPP EEEECCCCCCCCCCC	59.32	-
472	Phosphorylation	KKHCPVTSAAIPALP CCCCCCCCCCCCCCC	18.88	-
492	Phosphorylation	LTSGHQPSSVLRSPA CCCCCCCCHHHCCCC	26.89	-
583	Phosphorylation	TLGSSHRSSTPAPPP CCCCCCCCCCCCCCC	32.89	23527152
585	Phosphorylation	GSSHRSSTPAPPPGR CCCCCCCCCCCCCCC	25.39	24759943

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PIAS3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PIAS3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PIAS3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PIAS3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.