| UniProt ID | SPA24_MOUSE | |
|---|---|---|
| UniProt AC | Q6P926 | |
| Protein Name | Spermatogenesis-associated protein 24 | |
| Gene Name | Spata24 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 205 | |
| Subcellular Localization | Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm. Associated with chromatin. | |
| Protein Description | Binds DNA with high affinity but does not bind to TATA boxes. Synergises with GMNN and TBP in activation of TATA box-containing promoters and with GMNN and TBPL1 in activation of the NF1 TATA-less promoter. May play a role in cytoplasm movement and removal during spermiogenesis.. | |
| Protein Sequence | MATPLGWSQGGSGSVCLAFDQLRDVIESQEELIHQLRNVMVLQDENFVSKEEFHEIEKKLVEEKAAHAKTKALLAKEEEKLQFALGEVEVLSKQLEKEKMAFEKALSSVKSRVLQESSKKDQLITKCNEIESHIIKQEDILNGKENEIKELQQVISQQKQNFRNHISDFRIQKQQETYMAQVLDQKRKKATGMRRARSRQCSREK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 76 | Acetylation | KTKALLAKEEEKLQF HHHHHHHHHHHHHHH | 66.67 | 15608107 | |
| 117 | Phosphorylation | KSRVLQESSKKDQLI HHHHHHHHCHHHHHH | 34.20 | 28285833 | |
| 118 | Phosphorylation | SRVLQESSKKDQLIT HHHHHHHCHHHHHHH | 42.86 | 28285833 | |
| 122 (in isoform 2) | Phosphorylation | - | 43.58 | - | |
| 148 | Phosphorylation | LNGKENEIKELQQVI HCCCHHHHHHHHHHH | 6.74 | 24719451 | |
| 148 (in isoform 3) | Phosphorylation | - | 6.74 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SPA24_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SPA24_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SPA24_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| GEMI_MOUSE | Gmnn | physical | 19515240 | |
| SCMH1_MOUSE | Scmh1 | physical | 19515240 | |
| PHC2_MOUSE | Phc2 | physical | 19515240 | |
| RING2_MOUSE | Rnf2 | physical | 19515240 | |
| TBPL1_MOUSE | Tbpl1 | physical | 19515240 | |
| TBP_MOUSE | Tbp | physical | 19515240 | |
| TF2B_MOUSE | Gtf2b | physical | 19515240 | |
| SPA24_MOUSE | Spata24 | physical | 19515240 | |
| PCGF2_MOUSE | Pcgf2 | physical | 19515240 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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