HCFC1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HCFC1_MOUSE
• UniProt AC: Q61191
• Protein Name: Host cell factor 1
• Gene Name: Hcfc1 {ECO:0000312|MGI:MGI:105942}
• Organism: Mus musculus (Mouse).
• Sequence Length: 2045
• Subcellular Localization: Nucleus . Cytoplasm . HCFC1R1 modulates its subcellular localization and overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm (By similarity). Localizes to cytoplasm in trigeminal ganglia (PubMed:9990006). Non-processed HCFC1 ass
• Protein Description: Involved in control of the cell cycle. [PubMed: 9334261]
• Protein Sequence: MASAVSPANLPAVLLQPRWKRVVGWSGPVPRPRHGHRAVAIKELIVVFGGGNEGIVDELHVYNTATNQWFIPAVRGDIPPGCAAYGFVCDGTRLLVFGGMVEYGKYSNDLYELQASRWEWKRLKAKTPKNGPPPCPRLGHSFSLVGNKCYLFGGLANDSEDPKNNIPRYLNDLYILELRPGSGVVAWDIPITYGVLPPPRESHTAVVYTEKDNKKSKLVIYGGMSGCRLGDLWTLDIETLTWNKPSLSGVAPLPRSLHSATTIGNKMYVFGGWVPLVMDDVKVATHEKEWKCTNTLACLNLDTMAWETILMDTLEDNIPRARAGHCAVAINTRLYIWSGRDGYRKAWNNQVCCKDLWYLETEKPPPPARVQLVRANTNSLEVSWGAVATADSYLLQLQKYDIPATAATATSPTPNPVPSVPANPPKSPAPAAAAPAVQPLTQVGITLVPQAATAPPSTTTIQVLPTVPGSSISVPTAARTQGVPAVLKVTGPQATTGTPLVTMRPASQAGKAPVTVTSLPASVRMVVPTQSAQGTVIGSNPQMSGMAALAAAAAATQKIPPSSAPTVLSVPAGTTIVKTVAVTPGTTTLPATVKVASSPVMVSNPATRMLKTAAAQVGTSVSSAANTSTRPIITVHKSGTVTVAQQAQVVTTVVGGVTKTITLVKSPISVPGGSALISNLGKVMSVVQTKPVQTSAVTGQASTGPVTQIIQTKGPLPAGTILKLVTSADGKPTTIITTTQASGAGTKPTILGISSVSPSTTKPGTTTIIKTIPMSAIITQAGATGVTSSPGIKSPITIITTKVMTSGTGAPAKIITAVPKIATGHGQQGVTQVVLKGAPGQPGTILRTVPMGGVRLVTPVTVSAVKPAVTTLVVKGTTGVTTLGTVTGTVSTSLAGAGAHSTSASLATPITTLGTIATLSSQVINPTAITVSAAQTTLTAAGGLTTPTITMQPVSQPTQVTLITAPSGVEAQPVHDLPVSILASPTTEQPTATVTIADSGQGDVQPGTVTLVCSNPPCETHETGTTNTATTTVVANLGGHPQPTQVQFVCDRQETAASLVTSAVGQQNGNVVRVCSNPPCETHETGTTNTATTATSNMAGQHGCSNPPCETHETGTTSTATTAMSSMGTGQQRDTRRTTNTPTVVRITVAPGALERVQGTVKPQCQTQQTNMTTTTMTVQATGAPCSAGPLLRPSVALESGSHSPAFVQLALPSVRVGLSGPSSKDMPTGRQPETYHTYTTNTPTTTRSIMVAGELGAARVVPTSTYESLQASSPSSTMTMTALEALLCPSATVTQVCSNPPCETHETGTTNTATTSNAGSAQRVCSNPPCETHETGTTHTATTATSNGGAGQPEGGQQPASGHPCETHQTTSTGTTMSVSVGTLIPDATSSHGTLESGLEVVAVPTVTSQAGSTLLASFPTQRVCSNPPCETHETGTTHTATTVTSNMSSNQDPPPAASDQGEVASTQGDSTNITSASAITTSVSSTLPRAVTTVTQSTPVPGPSVPPPEELQVSPGPRQQLPPRQLLQSASTPLMGESTEVLSASQTPELQAAVDLSSTGDPSSGQEPTTSAVVATVVVQPPPPTQSEVDQLSLPQELMAEAQAGTTTLMVTGLTPEELAVTAAAEAAAQAAATEEAQALAIQAVLQAAQQAVMGTGEPMDTSEAAAAVTQAELGHLSAEGQEGQATTIPIVLTQQELAALVQQQQQLQEAQAQAQQQHHLPTEALAPADSLNDPSIESNCLNELASAVPSTVALLPSTATESLAPSNTFVAPQPVVASPAKMQAAATLTEVANGIESLGVKPDLPPPPSKAPVKKENQWFDVGVIKGTSVMVTHYFLPPDDAVQSDDDSGTVPDYNQLKKQELQPGTAYKFRVAGINACGRGPFSEISAFKTCLPGFPGAPCAIKISKSPDGAHLTWEPPSVTSGKIIEYSVYLAIQSSQASGEPKSSTPAQLAFMRVYCGPSPSCLVQSSSLSNAHIDYTTKPAIIFRIAARNEKGYGPATQVRWLQETSKDSSGTKPASKRPMSSPEMKSAPKKSKADGQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MASAVSPAN ------CCCCCCCCC	19.94	-
3	Phosphorylation	-----MASAVSPANL -----CCCCCCCCCC	40.85	27180971
6	Phosphorylation	--MASAVSPANLPAV --CCCCCCCCCCCCE	20.29	26824392
26	Phosphorylation	WKRVVGWSGPVPRPR HHEECCCCCCCCCCC	27.56	28066266
225	Phosphorylation	LVIYGGMSGCRLGDL EEEECCCCCCCCCCE	37.71	22871156
288	Acetylation	VKVATHEKEWKCTNT EEHHCCCCCCCCCCE	62.36	23806337
345	Acetylation	SGRDGYRKAWNNQVC ECCCCHHHHHCCCEE	49.63	22826441
354	Acetylation	WNNQVCCKDLWYLET HCCCEEEEEEEEEEC	51.21	22826441
363	Ubiquitination	LWYLETEKPPPPARV EEEEECCCCCCCCCE	70.96	-
400	Phosphorylation	YLLQLQKYDIPATAA HHHHHHCCCCCCCCC	13.22	25619855
405	O-linked_Glycosylation	QKYDIPATAATATSP HCCCCCCCCCCCCCC	16.09	55412177
405	Phosphorylation	QKYDIPATAATATSP HCCCCCCCCCCCCCC	16.09	25619855
408	Phosphorylation	DIPATAATATSPTPN CCCCCCCCCCCCCCC	28.18	22942356
410	Phosphorylation	PATAATATSPTPNPV CCCCCCCCCCCCCCC	30.77	27087446
411	Phosphorylation	ATAATATSPTPNPVP CCCCCCCCCCCCCCC	25.06	27087446
413	Phosphorylation	AATATSPTPNPVPSV CCCCCCCCCCCCCCC	35.15	27087446
419	Phosphorylation	PTPNPVPSVPANPPK CCCCCCCCCCCCCCC	40.75	25619855
427	Phosphorylation	VPANPPKSPAPAAAA CCCCCCCCCCCCCCC	31.87	23384938
480	O-linked_Glycosylation	SVPTAARTQGVPAVL ECCCCHHCCCCCEEE	25.58	37821623
490	O-linked_Glycosylation	VPAVLKVTGPQATTG CCEEEEEECCCCCCC	41.37	21540332
490	Phosphorylation	VPAVLKVTGPQATTG CCEEEEEECCCCCCC	41.37	29895711
495	O-linked_Glycosylation	KVTGPQATTGTPLVT EEECCCCCCCCCEEE	22.10	29406809
495	Phosphorylation	KVTGPQATTGTPLVT EEECCCCCCCCCEEE	22.10	29895711
496	O-linked_Glycosylation	VTGPQATTGTPLVTM EECCCCCCCCCEEEE	41.91	21580483
496	Phosphorylation	VTGPQATTGTPLVTM EECCCCCCCCCEEEE	41.91	29895711
498	Phosphorylation	GPQATTGTPLVTMRP CCCCCCCCCEEEEEE	16.03	29895711
504	Methylation	GTPLVTMRPASQAGK CCCEEEEEEHHHCCC	17.80	24129315
515	O-linked_Glycosylation	QAGKAPVTVTSLPAS HCCCCCEEEEECCCE	19.60	46224425
524	Methylation	TSLPASVRMVVPTQS EECCCEEEEEEECCC	15.07	24129315
563	O-linked_Glycosylation	TQKIPPSSAPTVLSV HCCCCCCCCCEEEEE	44.00	21540332
574	O-linked_Glycosylation	VLSVPAGTTIVKTVA EEEECCCCEEEEEEE	18.56	34871595
579	O-linked_Glycosylation	AGTTIVKTVAVTPGT CCCEEEEEEEECCCC	11.64	21540332
583	O-linked_Glycosylation	IVKTVAVTPGTTTLP EEEEEEECCCCCCCC	13.28	34871611
586	Phosphorylation	TVAVTPGTTTLPATV EEEECCCCCCCCEEE	20.15	26026062
587	Phosphorylation	VAVTPGTTTLPATVK EEECCCCCCCCEEEE	32.05	26026062
588	O-linked_Glycosylation	AVTPGTTTLPATVKV EECCCCCCCCEEEEE	30.49	55412169
588	Phosphorylation	AVTPGTTTLPATVKV EECCCCCCCCEEEEE	30.49	26026062
597	Phosphorylation	PATVKVASSPVMVSN CEEEEECCCCEEECC	37.86	22942356
598	Phosphorylation	ATVKVASSPVMVSNP EEEEECCCCEEECCH	16.27	23527152
603	Phosphorylation	ASSPVMVSNPATRML CCCCEEECCHHHHHH	20.99	28833060
607	Phosphorylation	VMVSNPATRMLKTAA EEECCHHHHHHHHHH	20.19	28833060
620	O-linked_Glycosylation	AAAQVGTSVSSAANT HHHHHCCCHHHHCCC	17.67	51588099
622	O-linked_Glycosylation	AQVGTSVSSAANTST HHHCCCHHHHCCCCC	17.64	21540332
623	O-linked_Glycosylation	QVGTSVSSAANTSTR HHCCCHHHHCCCCCC	29.28	21540332
629	Phosphorylation	SSAANTSTRPIITVH HHHCCCCCCCEEEEE	38.12	28576409
651	O-linked_Glycosylation	AQQAQVVTTVVGGVT HEECEEEEEEECCEE	18.28	51588091
652	O-linked_Glycosylation	QQAQVVTTVVGGVTK EECEEEEEEECCEEE	11.11	51588139
652	Phosphorylation	QQAQVVTTVVGGVTK EECEEEEEEECCEEE	11.11	22705319
660	Phosphorylation	VVGGVTKTITLVKSP EECCEEEEEEEECCC	15.16	26643407
662	Phosphorylation	GGVTKTITLVKSPIS CCEEEEEEEECCCCC	30.63	26239621
665	Ubiquitination	TKTITLVKSPISVPG EEEEEEECCCCCCCC	54.34	-
666	Phosphorylation	KTITLVKSPISVPGG EEEEEECCCCCCCCH	21.71	27087446
669	Phosphorylation	TLVKSPISVPGGSAL EEECCCCCCCCHHHH	26.16	25521595
674	Phosphorylation	PISVPGGSALISNLG CCCCCCHHHHHHCHH	26.30	21659605
678	Phosphorylation	PGGSALISNLGKVMS CCHHHHHHCHHHEEE	27.18	25777480
685	O-linked_Glycosylation	SNLGKVMSVVQTKPV HCHHHEEEEEECCCC	23.32	21540332
685	Phosphorylation	SNLGKVMSVVQTKPV HCHHHEEEEEECCCC	23.32	25777480
689	Phosphorylation	KVMSVVQTKPVQTSA HEEEEEECCCCCCCC	26.21	25777480
690	Acetylation	VMSVVQTKPVQTSAV EEEEEECCCCCCCCC	26.54	22826441
694	Phosphorylation	VQTKPVQTSAVTGQA EECCCCCCCCCCCCC	20.91	25777480
695	Phosphorylation	QTKPVQTSAVTGQAS ECCCCCCCCCCCCCC	12.03	25777480
698	Phosphorylation	PVQTSAVTGQASTGP CCCCCCCCCCCCCCC	24.24	25777480
702	Phosphorylation	SAVTGQASTGPVTQI CCCCCCCCCCCCEEE	26.47	25777480
703	Phosphorylation	AVTGQASTGPVTQII CCCCCCCCCCCEEEE	48.82	25777480
707	Phosphorylation	QASTGPVTQIIQTKG CCCCCCCEEEEEECC	19.72	25777480
712	Phosphorylation	PVTQIIQTKGPLPAG CCEEEEEECCCCCCC	27.79	25777480
779	O-linked_Glycosylation	IPMSAIITQAGATGV EEHHHEEECCCCCCC	13.27	21540332
787	Phosphorylation	QAGATGVTSSPGIKS CCCCCCCCCCCCCCC	25.49	26643407
788	Phosphorylation	AGATGVTSSPGIKSP CCCCCCCCCCCCCCC	31.93	26643407
789	Phosphorylation	GATGVTSSPGIKSPI CCCCCCCCCCCCCCE	20.13	26643407
794	O-linked_Glycosylation	TSSPGIKSPITIITT CCCCCCCCCEEEEEE	21.44	21778773
794	Phosphorylation	TSSPGIKSPITIITT CCCCCCCCCEEEEEE	21.44	27841257
797	O-linked_Glycosylation	PGIKSPITIITTKVM CCCCCCEEEEEEEEE	15.09	21778777
800	O-linked_Glycosylation	KSPITIITTKVMTSG CCCEEEEEEEEECCC	19.40	30059200
801	O-linked_Glycosylation	SPITIITTKVMTSGT CCEEEEEEEEECCCC	15.95	30059200
802	Acetylation	PITIITTKVMTSGTG CEEEEEEEEECCCCC	22.74	22826441
805	O-linked_Glycosylation	IITTKVMTSGTGAPA EEEEEEECCCCCCCC	27.30	8527405
806	O-linked_Glycosylation	ITTKVMTSGTGAPAK EEEEEECCCCCCCCE	19.09	8527411
808	O-linked_Glycosylation	TKVMTSGTGAPAKII EEEECCCCCCCCEEE	29.91	30059200
813	Acetylation	SGTGAPAKIITAVPK CCCCCCCEEEEECCE	33.31	23806337
820	Acetylation	KIITAVPKIATGHGQ EEEEECCEECCCCCC	38.07	22826441
831	O-linked_Glycosylation	GHGQQGVTQVVLKGA CCCCCCEEEEEECCC	23.59	55412185
836	Acetylation	GVTQVVLKGAPGQPG CEEEEEECCCCCCCC	41.22	22826441
836	Ubiquitination	GVTQVVLKGAPGQPG CEEEEEECCCCCCCC	41.22	-
847	Methylation	GQPGTILRTVPMGGV CCCCCEEEEEECCCE	29.81	-
848	Phosphorylation	QPGTILRTVPMGGVR CCCCEEEEEECCCEE	26.05	27180971
861	O-linked_Glycosylation	VRLVTPVTVSAVKPA EEEEECEEHHHCCCE	15.22	29406875
870	O-linked_Glycosylation	SAVKPAVTTLVVKGT HHCCCEEEEEEEECC	19.27	51588131
1139	O-linked_Glycosylation	QRDTRRTTNTPTVVR CCCCCCCCCCCEEEE	34.97	51588083
1139	Phosphorylation	QRDTRRTTNTPTVVR CCCCCCCCCCCEEEE	34.97	26060331
1141	Phosphorylation	DTRRTTNTPTVVRIT CCCCCCCCCEEEEEE	20.46	27149854
1143	Phosphorylation	RRTTNTPTVVRITVA CCCCCCCEEEEEEEC	29.60	28066266
1148	O-linked_Glycosylation	TPTVVRITVAPGALE CCEEEEEEECCCHHH	10.47	21540332
1148	Phosphorylation	TPTVVRITVAPGALE CCEEEEEEECCCHHH	10.47	-
1204	Phosphorylation	ALESGSHSPAFVQLA ECCCCCCCCHHHHEE	21.44	-
1216	Asymmetric dimethylarginine	QLALPSVRVGLSGPS HEECCCCEEECCCCC	22.56	-
1216	Methylation	QLALPSVRVGLSGPS HEECCCCEEECCCCC	22.56	24129315
1220	Phosphorylation	PSVRVGLSGPSSKDM CCCEEECCCCCCCCC	42.61	28059163
1223	Phosphorylation	RVGLSGPSSKDMPTG EEECCCCCCCCCCCC	54.25	-
1238	O-linked_Glycosylation	RQPETYHTYTTNTPT CCCCCEEEEECCCCC	16.49	21540332
1240	O-linked_Glycosylation	PETYHTYTTNTPTTT CCCEEEEECCCCCCC	18.09	21540332
1241	O-linked_Glycosylation	ETYHTYTTNTPTTTR CCEEEEECCCCCCCC	27.04	21540332
1243	Phosphorylation	YHTYTTNTPTTTRSI EEEEECCCCCCCCEE	21.66	25338131
1246	O-linked_Glycosylation	YTTNTPTTTRSIMVA EECCCCCCCCEEEEC	22.78	51588067
1247	O-linked_Glycosylation	TTNTPTTTRSIMVAG ECCCCCCCCEEEECC	25.54	51588075
1494	Phosphorylation	STLPRAVTTVTQSTP CCCCCCEEEEEECCC	17.98	25619855
1495	Phosphorylation	TLPRAVTTVTQSTPV CCCCCEEEEEECCCC	18.24	25619855
1497	Phosphorylation	PRAVTTVTQSTPVPG CCCEEEEEECCCCCC	18.08	25619855
1499	Phosphorylation	AVTTVTQSTPVPGPS CEEEEEECCCCCCCC	25.88	25619855
1500	Phosphorylation	VTTVTQSTPVPGPSV EEEEEECCCCCCCCC	20.63	25619855
1506	Phosphorylation	STPVPGPSVPPPEEL CCCCCCCCCCCCHHH	53.85	25619855
1516	Phosphorylation	PPEELQVSPGPRQQL CCHHHCCCCCCHHCC	15.92	25521595
1781	Phosphorylation	APQPVVASPAKMQAA CCCCCCCCHHHHHHH	17.49	-
1818	Ubiquitination	PSKAPVKKENQWFDV CCCCCCCCCCCCEEE	63.23	-
1831	Phosphorylation	DVGVIKGTSVMVTHY EEEEEECCEEEEEEE	17.10	28833060
1832	Phosphorylation	VGVIKGTSVMVTHYF EEEEECCEEEEEEEE	19.51	28833060
1836	Phosphorylation	KGTSVMVTHYFLPPD ECCEEEEEEEECCCH	7.86	28833060
1838	Phosphorylation	TSVMVTHYFLPPDDA CEEEEEEEECCCHHC	9.46	28833060
1848	Phosphorylation	PPDDAVQSDDDSGTV CCHHCCCCCCCCCCC	36.09	27087446
1852	Phosphorylation	AVQSDDDSGTVPDYN CCCCCCCCCCCCCHH	43.27	27087446
1854	Phosphorylation	QSDDDSGTVPDYNQL CCCCCCCCCCCHHHH	32.58	27087446
1858	Phosphorylation	DSGTVPDYNQLKKQE CCCCCCCHHHHHHCC	9.95	28833060
1873	Acetylation	LQPGTAYKFRVAGIN CCCCCCEEEEEEEEC	24.99	22826441
1873	Ubiquitination	LQPGTAYKFRVAGIN CCCCCCEEEEEEEEC	24.99	-
1911	Acetylation	PCAIKISKSPDGAHL CEEEEEEECCCCCEE	70.27	22826441
1952	Phosphorylation	SGEPKSSTPAQLAFM CCCCCCCCHHHHEEE	29.72	22006019
1999	Acetylation	RIAARNEKGYGPATQ EEECCCCCCCCCHHH	62.07	23806337
2015	Acetylation	RWLQETSKDSSGTKP HHHHHCCCCCCCCCC	69.88	-
2017	Phosphorylation	LQETSKDSSGTKPAS HHHCCCCCCCCCCCC	34.11	25338131
2029	Phosphorylation	PASKRPMSSPEMKSA CCCCCCCCCHHHHCC	45.48	25521595
2030	Phosphorylation	ASKRPMSSPEMKSAP CCCCCCCCHHHHCCC	20.73	25521595

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HCFC1_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
48	K	ubiquitylation	Lys-1817 and Lys-1818 are ubiquitinated both via 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.	-
1817	K	ubiquitylation	Lys-1817 and Lys-1818 are ubiquitinated both via 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.	-
1818	K	ubiquitylation	Lys-1817 and Lys-1818 are ubiquitinated both via 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HCFC1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of HCFC1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.