dbPTM

H12_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	H12_MOUSE
UniProt AC	P15864
Protein Name	Histone H1.2
Gene Name	Hist1h1c
Organism	Mus musculus (Mouse).
Sequence Length	212
Subcellular Localization	Nucleus. Chromosome. Mainly localizes in euchromatin..
Protein Description	Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity)..
Protein Sequence	MSEAAPAAPAAAPPAEKAPAKKKAAKKPAGVRRKASGPPVSELITKAVAASKERSGVSLAALKKALAAAGYDVEKNNSRIKLGLKSLVSKGILVQTKGTGASGSFKLNKKAASGEAKPQAKKAGAAKAKKPAGAAKKPKKATGAATPKKAAKKTPKKAKKPAAAAVTKKVAKSPKKAKVTKPKKVKSASKAVKPKAAKPKVAKAKKVAAKKK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSEAAPAAP ------CCCCCCCCC	35.62	23806337
2	Phosphorylation	------MSEAAPAAP ------CCCCCCCCC	35.62	23527152
17	Acetylation	AAAPPAEKAPAKKKA CCCCHHHHCCHHHHH	62.87	23806337
17	Methylation	AAAPPAEKAPAKKKA CCCCHHHHCCHHHHH	62.87	22693562
17	Succinylation	AAAPPAEKAPAKKKA CCCCHHHHCCHHHHH	62.87	23806337
17	Ubiquitination	AAAPPAEKAPAKKKA CCCCHHHHCCHHHHH	62.87	-
21	Ubiquitination	PAEKAPAKKKAAKKP HHHHCCHHHHHCCCC	54.47	-
22	Methylation	AEKAPAKKKAAKKPA HHHCCHHHHHCCCCC	50.15	22693562
23	Acetylation	EKAPAKKKAAKKPAG HHCCHHHHHCCCCCC	53.52	19737024
23	Hydroxylation	EKAPAKKKAAKKPAG HHCCHHHHHCCCCCC	53.52	24681537
23	Other	EKAPAKKKAAKKPAG HHCCHHHHHCCCCCC	53.52	24681537
26	Acetylation	PAKKKAAKKPAGVRR CHHHHHCCCCCCCCC	65.24	-
26	Hydroxylation	PAKKKAAKKPAGVRR CHHHHHCCCCCCCCC	65.24	24681537
26	Methylation	PAKKKAAKKPAGVRR CHHHHHCCCCCCCCC	65.24	22693562
26	Other	PAKKKAAKKPAGVRR CHHHHHCCCCCCCCC	65.24	24681537
26	Ubiquitination	PAKKKAAKKPAGVRR CHHHHHCCCCCCCCC	65.24	-
27	Hydroxylation	AKKKAAKKPAGVRRK HHHHHCCCCCCCCCC	35.06	24681537
27	Other	AKKKAAKKPAGVRRK HHHHHCCCCCCCCCC	35.06	24681537
27	Ubiquitination	AKKKAAKKPAGVRRK HHHHHCCCCCCCCCC	35.06	-
34	N6-crotonyl-L-lysine	KPAGVRRKASGPPVS CCCCCCCCCCCCCHH	36.02	-
34	Acetylation	KPAGVRRKASGPPVS CCCCCCCCCCCCCHH	36.02	23806337
34	Crotonylation	KPAGVRRKASGPPVS CCCCCCCCCCCCCHH	36.02	21925322
34	Hydroxylation	KPAGVRRKASGPPVS CCCCCCCCCCCCCHH	36.02	24681537
34	Malonylation	KPAGVRRKASGPPVS CCCCCCCCCCCCCHH	36.02	26320211
34	Methylation	KPAGVRRKASGPPVS CCCCCCCCCCCCCHH	36.02	22693562
34	Other	KPAGVRRKASGPPVS CCCCCCCCCCCCCHH	36.02	-
34	Succinylation	KPAGVRRKASGPPVS CCCCCCCCCCCCCHH	36.02	23806337
34	Ubiquitination	KPAGVRRKASGPPVS CCCCCCCCCCCCCHH	36.02	-
36	Phosphorylation	AGVRRKASGPPVSEL CCCCCCCCCCCHHHH	55.67	27087446
41	Phosphorylation	KASGPPVSELITKAV CCCCCCHHHHHHHHH	32.24	24068923
45	Phosphorylation	PPVSELITKAVAASK CCHHHHHHHHHHHCH	26.10	24068923
46	Acetylation	PVSELITKAVAASKE CHHHHHHHHHHHCHH	33.59	22826441
46	Other	PVSELITKAVAASKE CHHHHHHHHHHHCHH	33.59	24681537
46	Succinylation	PVSELITKAVAASKE CHHHHHHHHHHHCHH	33.59	23806337
46	Ubiquitination	PVSELITKAVAASKE CHHHHHHHHHHHCHH	33.59	-
52	Acetylation	TKAVAASKERSGVSL HHHHHHCHHCCCCCH	53.04	17043054
52	Crotonylation	TKAVAASKERSGVSL HHHHHHCHHCCCCCH	53.04	22693562
52	Hydroxylation	TKAVAASKERSGVSL HHHHHHCHHCCCCCH	53.04	24681537
52	Methylation	TKAVAASKERSGVSL HHHHHHCHHCCCCCH	53.04	22693562
52	Other	TKAVAASKERSGVSL HHHHHHCHHCCCCCH	53.04	24681537
52	Ubiquitination	TKAVAASKERSGVSL HHHHHHCHHCCCCCH	53.04	-
54	Citrullination	AVAASKERSGVSLAA HHHHCHHCCCCCHHH	42.31	-
54	Citrullination	AVAASKERSGVSLAA HHHHCHHCCCCCHHH	42.31	24463520
55	Phosphorylation	VAASKERSGVSLAAL HHHCHHCCCCCHHHH	44.64	24899341
58	Phosphorylation	SKERSGVSLAALKKA CHHCCCCCHHHHHHH	18.80	26745281
63	Acetylation	GVSLAALKKALAAAG CCCHHHHHHHHHHCC	31.13	23806337
63	Hydroxylation	GVSLAALKKALAAAG CCCHHHHHHHHHHCC	31.13	24681537
63	Malonylation	GVSLAALKKALAAAG CCCHHHHHHHHHHCC	31.13	26320211
63	Other	GVSLAALKKALAAAG CCCHHHHHHHHHHCC	31.13	24681537
63	Ubiquitination	GVSLAALKKALAAAG CCCHHHHHHHHHHCC	31.13	-
64	N6-crotonyl-L-lysine	VSLAALKKALAAAGY CCHHHHHHHHHHCCC	49.86	-
64	Crotonylation	VSLAALKKALAAAGY CCHHHHHHHHHHCCC	49.86	21925322
64	Malonylation	VSLAALKKALAAAGY CCHHHHHHHHHHCCC	49.86	26320211
64	Other	VSLAALKKALAAAGY CCHHHHHHHHHHCCC	49.86	24681537
64	Ubiquitination	VSLAALKKALAAAGY CCHHHHHHHHHHCCC	49.86	-
71	Phosphorylation	KALAAAGYDVEKNNS HHHHHCCCCCHHCCC	16.46	26026062
75	Acetylation	AAGYDVEKNNSRIKL HCCCCCHHCCCCHHH	62.37	22826441
75	Hydroxylation	AAGYDVEKNNSRIKL HCCCCCHHCCCCHHH	62.37	24681537
75	Other	AAGYDVEKNNSRIKL HCCCCCHHCCCCHHH	62.37	24681537
75	Succinylation	AAGYDVEKNNSRIKL HCCCCCHHCCCCHHH	62.37	23806337
75	Ubiquitination	AAGYDVEKNNSRIKL HCCCCCHHCCCCHHH	62.37	-
78	Phosphorylation	YDVEKNNSRIKLGLK CCCHHCCCCHHHHHH	44.79	29176673
81	Hydroxylation	EKNNSRIKLGLKSLV HHCCCCHHHHHHHHH	35.08	24681537
81	Other	EKNNSRIKLGLKSLV HHCCCCHHHHHHHHH	35.08	24681537
85	N6-crotonyl-L-lysine	SRIKLGLKSLVSKGI CCHHHHHHHHHHCCE	39.69	-
85	Acetylation	SRIKLGLKSLVSKGI CCHHHHHHHHHHCCE	39.69	23806337
85	Crotonylation	SRIKLGLKSLVSKGI CCHHHHHHHHHHCCE	39.69	21925322
85	Hydroxylation	SRIKLGLKSLVSKGI CCHHHHHHHHHHCCE	39.69	24681537
85	Malonylation	SRIKLGLKSLVSKGI CCHHHHHHHHHHCCE	39.69	26320211
85	Other	SRIKLGLKSLVSKGI CCHHHHHHHHHHCCE	39.69	24681537
85	Ubiquitination	SRIKLGLKSLVSKGI CCHHHHHHHHHHCCE	39.69	-
86	Phosphorylation	RIKLGLKSLVSKGIL CHHHHHHHHHHCCEE	38.76	24704852
90	N6-crotonyl-L-lysine	GLKSLVSKGILVQTK HHHHHHHCCEEEEEC	42.35	-
90	Acetylation	GLKSLVSKGILVQTK HHHHHHHCCEEEEEC	42.35	23806337
90	Crotonylation	GLKSLVSKGILVQTK HHHHHHHCCEEEEEC	42.35	-
90	Other	GLKSLVSKGILVQTK HHHHHHHCCEEEEEC	42.35	24681537
90	Ubiquitination	GLKSLVSKGILVQTK HHHHHHHCCEEEEEC	42.35	-
97	N6-crotonyl-L-lysine	KGILVQTKGTGASGS CCEEEEECCCCCCCC	37.07	-
97	Acetylation	KGILVQTKGTGASGS CCEEEEECCCCCCCC	37.07	23806337
97	Crotonylation	KGILVQTKGTGASGS CCEEEEECCCCCCCC	37.07	-
97	Hydroxylation	KGILVQTKGTGASGS CCEEEEECCCCCCCC	37.07	24681537
97	Methylation	KGILVQTKGTGASGS CCEEEEECCCCCCCC	37.07	22693562
97	Other	KGILVQTKGTGASGS CCEEEEECCCCCCCC	37.07	24681537
97	Succinylation	KGILVQTKGTGASGS CCEEEEECCCCCCCC	37.07	23806337
97	Ubiquitination	KGILVQTKGTGASGS CCEEEEECCCCCCCC	37.07	-
99	Phosphorylation	ILVQTKGTGASGSFK EEEEECCCCCCCCEE	31.00	29899451
102	Phosphorylation	QTKGTGASGSFKLNK EECCCCCCCCEECCH	35.99	26824392
104	Phosphorylation	KGTGASGSFKLNKKA CCCCCCCCEECCHHH	19.40	25521595
106	Acetylation	TGASGSFKLNKKAAS CCCCCCEECCHHHCC	53.50	23806337
106	Malonylation	TGASGSFKLNKKAAS CCCCCCEECCHHHCC	53.50	26320211
106	Other	TGASGSFKLNKKAAS CCCCCCEECCHHHCC	53.50	-
106	Succinylation	TGASGSFKLNKKAAS CCCCCCEECCHHHCC	53.50	23806337
106	Ubiquitination	TGASGSFKLNKKAAS CCCCCCEECCHHHCC	53.50	-
109	Ubiquitination	SGSFKLNKKAASGEA CCCEECCHHHCCCCC	54.98	-
110	Acetylation	GSFKLNKKAASGEAK CCEECCHHHCCCCCC	48.38	7612937
110	Hydroxylation	GSFKLNKKAASGEAK CCEECCHHHCCCCCC	48.38	24681537
110	Methylation	GSFKLNKKAASGEAK CCEECCHHHCCCCCC	48.38	22693562
110	Other	GSFKLNKKAASGEAK CCEECCHHHCCCCCC	48.38	24681537
113	Phosphorylation	KLNKKAASGEAKPQA ECCHHHCCCCCCHHH	41.86	23684622
117	Hydroxylation	KAASGEAKPQAKKAG HHCCCCCCHHHHHHC	33.10	24681537
117	Other	KAASGEAKPQAKKAG HHCCCCCCHHHHHHC	33.10	24681537
121	Acetylation	GEAKPQAKKAGAAKA CCCCHHHHHHCHHHC	37.60	23806337
121	Hydroxylation	GEAKPQAKKAGAAKA CCCCHHHHHHCHHHC	37.60	24681537
121	Other	GEAKPQAKKAGAAKA CCCCHHHHHHCHHHC	37.60	24681537
121	Succinylation	GEAKPQAKKAGAAKA CCCCHHHHHHCHHHC	37.60	23806337
127	Acetylation	AKKAGAAKAKKPAGA HHHHCHHHCCCCCCC	61.27	19737024
129	Acetylation	KAGAAKAKKPAGAAK HHCHHHCCCCCCCCC	59.59	165971
129	Hydroxylation	KAGAAKAKKPAGAAK HHCHHHCCCCCCCCC	59.59	24681537
129	Other	KAGAAKAKKPAGAAK HHCHHHCCCCCCCCC	59.59	24681537
130	Acetylation	AGAAKAKKPAGAAKK HCHHHCCCCCCCCCC	44.98	165975
136	Acetylation	KKPAGAAKKPKKATG CCCCCCCCCCCCCCC	69.90	19737024
136	Hydroxylation	KKPAGAAKKPKKATG CCCCCCCCCCCCCCC	69.90	24681537
136	Other	KKPAGAAKKPKKATG CCCCCCCCCCCCCCC	69.90	24681537
137	Acetylation	KPAGAAKKPKKATGA CCCCCCCCCCCCCCC	58.29	19737024
146	Phosphorylation	KKATGAATPKKAAKK CCCCCCCCHHHHHCC	34.80	26824392
148	Hydroxylation	ATGAATPKKAAKKTP CCCCCCHHHHHCCCC	51.17	24681537
148	Other	ATGAATPKKAAKKTP CCCCCCHHHHHCCCC	51.17	24681537
154	Phosphorylation	PKKAAKKTPKKAKKP HHHHHCCCCCCCCCH	39.37	-
157	Ubiquitination	AAKKTPKKAKKPAAA HHCCCCCCCCCHHHH	67.64	-
159	N6-crotonyl-L-lysine	KKTPKKAKKPAAAAV CCCCCCCCCHHHHHH	69.07	-
159	Acetylation	KKTPKKAKKPAAAAV CCCCCCCCCHHHHHH	69.07	22902405
159	Crotonylation	KKTPKKAKKPAAAAV CCCCCCCCCHHHHHH	69.07	21925322
159	Hydroxylation	KKTPKKAKKPAAAAV CCCCCCCCCHHHHHH	69.07	24681537
159	Malonylation	KKTPKKAKKPAAAAV CCCCCCCCCHHHHHH	69.07	26320211
159	Other	KKTPKKAKKPAAAAV CCCCCCCCCHHHHHH	69.07	24681537
159	Ubiquitination	KKTPKKAKKPAAAAV CCCCCCCCCHHHHHH	69.07	-
160	Acetylation	KTPKKAKKPAAAAVT CCCCCCCCHHHHHHH	44.76	17043054
160	Malonylation	KTPKKAKKPAAAAVT CCCCCCCCHHHHHHH	44.76	26320211
160	Ubiquitination	KTPKKAKKPAAAAVT CCCCCCCCHHHHHHH	44.76	-
168	N6-crotonyl-L-lysine	PAAAAVTKKVAKSPK HHHHHHHHHHHCCCC	38.36	-
168	Acetylation	PAAAAVTKKVAKSPK HHHHHHHHHHHCCCC	38.36	22693562
168	Crotonylation	PAAAAVTKKVAKSPK HHHHHHHHHHHCCCC	38.36	21925322
168	Hydroxylation	PAAAAVTKKVAKSPK HHHHHHHHHHHCCCC	38.36	24681537
168	Other	PAAAAVTKKVAKSPK HHHHHHHHHHHCCCC	38.36	24681537
168	Ubiquitination	PAAAAVTKKVAKSPK HHHHHHHHHHHCCCC	38.36	-
173	Phosphorylation	VTKKVAKSPKKAKVT HHHHHHCCCCCCCCC	32.01	23684622
175	Acetylation	KKVAKSPKKAKVTKP HHHHCCCCCCCCCCC	72.89	22826441
176	Acetylation	KVAKSPKKAKVTKPK HHHCCCCCCCCCCCH	57.75	22826441
178	Acetylation	AKSPKKAKVTKPKKV HCCCCCCCCCCCHHH	60.35	17043054
180	Phosphorylation	SPKKAKVTKPKKVKS CCCCCCCCCCHHHCC	40.71	27149854
186	Methylation	VTKPKKVKSASKAVK CCCCHHHCCCCCCCC	49.54	-
187	ADP-ribosylation	TKPKKVKSASKAVKP CCCHHHCCCCCCCCC	40.54	-
187	Phosphorylation	TKPKKVKSASKAVKP CCCHHHCCCCCCCCC	40.54	-
189	Phosphorylation	PKKVKSASKAVKPKA CHHHCCCCCCCCCCC	28.39	28059163
212	Hydroxylation	KKVAAKKK------- HHHHCCCC-------	65.94	24681537
212	Other	KKVAAKKK------- HHHHCCCC-------	65.94	24681537

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
104	S	Phosphorylation	Kinase	PKC	-	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
54	R	Citrullination		24463520
Citrullination at Arg-54 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of H12_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of H12_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of H12_MOUSE

Related Literatures of Post-Translational Modification

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