UniProt ID | EED_MOUSE | |
---|---|---|
UniProt AC | Q921E6 | |
Protein Name | Polycomb protein EED | |
Gene Name | Eed | |
Organism | Mus musculus (Mouse). | |
Sequence Length | 441 | |
Subcellular Localization | Nucleus. Chromosome. Localizes to the inactive X chromosome in cells of the early embryo and in stem cells of the extraembryonic trophectoderm lineage. Recruitment to the inactive X-chromosome requires XIST. | |
Protein Description | Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark (By similarity). The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (By similarity). Genes repressed by the PRC2/EED-EZH2 complex include HOXA7, HOXB6 and HOXC8. Plays a role in X chromosome inactivation (XCI), in which one of the two X chromosomes in female mammals is transcriptionally silenced to equalize X-linked gene dosage with XY males. Required for stable maintenance of XCI in both embryonic and extraembryonic tissues. May prevent transcriptional activation of facultative heterochromatin during differentiation. Required for development of secondary trophoblast giant cells during placental development. May regulate hippocampal synaptic plasticity in the developing brain.. | |
Protein Sequence | MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
2 | Phosphorylation | ------MSEREVSTA ------CCCCCCCCC | 45.41 | 25266776 | |
2 | Acetylation | ------MSEREVSTA ------CCCCCCCCC | 45.41 | - | |
8 | Phosphorylation | MSEREVSTAPAGTDM CCCCCCCCCCCCCCC | 41.66 | 26643407 | |
13 | Phosphorylation | VSTAPAGTDMPAAKK CCCCCCCCCCCHHHH | 31.09 | 26643407 | |
24 | Phosphorylation | AAKKQKLSSDENSNP HHHHHCCCCCCCCCC | 42.66 | 25159016 | |
25 | Phosphorylation | AKKQKLSSDENSNPD HHHHCCCCCCCCCCC | 60.42 | 25159016 | |
29 | Phosphorylation | KLSSDENSNPDLSGD CCCCCCCCCCCCCCC | 47.92 | 21149613 | |
34 | Phosphorylation | ENSNPDLSGDENDDA CCCCCCCCCCCCCCC | 52.13 | 21082442 | |
43 | Phosphorylation | DENDDAVSIESGTNT CCCCCCEEECCCCCC | 23.51 | 25159016 | |
46 | Phosphorylation | DDAVSIESGTNTERP CCCEEECCCCCCCCC | 49.61 | 25159016 | |
48 | Phosphorylation | AVSIESGTNTERPDT CEEECCCCCCCCCCC | 48.52 | 25159016 | |
50 | Phosphorylation | SIESGTNTERPDTPT EECCCCCCCCCCCCC | 32.96 | 25159016 | |
55 | Phosphorylation | TNTERPDTPTNTPNA CCCCCCCCCCCCCCC | 34.39 | 25159016 | |
56 (in isoform 2) | Methylation | - | 30.91 | - | |
57 | Phosphorylation | TERPDTPTNTPNAPG CCCCCCCCCCCCCCC | 54.54 | 25159016 | |
57 (in isoform 2) | Methylation | - | 54.54 | - | |
58 (in isoform 2) | Methylation | - | 55.53 | - | |
59 | Phosphorylation | RPDTPTNTPNAPGRK CCCCCCCCCCCCCCC | 22.01 | 25777480 | |
61 (in isoform 2) | Phosphorylation | - | 57.64 | 24453211 | |
66 | Methylation | TPNAPGRKSWGKGKW CCCCCCCCCCCCCCC | 57.38 | - | |
66 (in isoform 2) | Phosphorylation | - | 57.38 | 29895711 | |
66 | "N6,N6,N6-trimethyllysine" | TPNAPGRKSWGKGKW CCCCCCCCCCCCCCC | 57.38 | - | |
67 (in isoform 2) | Phosphorylation | - | 39.43 | 24759943 | |
197 | Methylation | GNAINELKFHPRDPN CHHHCEECCCCCCCC | 35.13 | - | |
197 | "N6,N6,N6-trimethyllysine" | GNAINELKFHPRDPN CHHHCEECCCCCCCC | 35.13 | - | |
208 | Phosphorylation | RDPNLLLSVSKDHAL CCCCEEEEEEHHHHH | 25.06 | 22006019 | |
211 | Acetylation | NLLLSVSKDHALRLW CEEEEEEHHHHHHHH | 51.91 | 6569317 | |
250 | Acetylation | DYDLLGEKIMSCGMD CHHHHHHHHHHCCCC | 41.74 | 19857279 | |
261 | Acetylation | CGMDHSLKLWRINSK CCCCHHHHHHHCCHH | 49.36 | 19857287 | |
268 | Methylation | KLWRINSKRMMNAIK HHHHCCHHHHHHHHH | 39.56 | - | |
268 | "N6,N6,N6-trimethyllysine" | KLWRINSKRMMNAIK HHHHCCHHHHHHHHH | 39.56 | - | |
284 | Methylation | SYDYNPNKTNRPFIS HHCCCCCCCCCCCCC | 48.73 | - | |
284 | "N6,N6,N6-trimethyllysine" | SYDYNPNKTNRPFIS HHCCCCCCCCCCCCC | 48.73 | - |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of EED_MOUSE !! |
Modified Location | Modified Residue | Modification | Function | Reference |
---|---|---|---|---|
26 | K | Methylation |
| - |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of EED_MOUSE !! |
Kegg Drug | ||||||
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DrugBank | ||||||
There are no disease associations of PTM sites. |
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