GUC2E_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GUC2E_MOUSE
• UniProt AC: P52785
• Protein Name: Guanylyl cyclase GC-E
• Gene Name: Gucy2e
• Organism: Mus musculus (Mouse).
• Sequence Length: 1108
• Subcellular Localization: Membrane; Single-pass type I membrane protein.
• Protein Sequence: MSAWLLPAGGLPGAGFCVPARQSPSSFSRVLRWPRPGLPGLLLLLLLPSPSALSAVFKVGVLGPWACDPIFARARPDLAARLAANRLNRDFALDGGPRFEVALLPEPCLTPGSLGAVSSALSRVSGLVGPVNPAACRPAELLAQEAGVALVPWGCPGTRAAGTTAPAVTPAADALYVLLRAFRWARVALITAPQDLWVEAGRALSTALRARGLPVALVTSMETSDRSGAREALGRIRDGPRVRVVIMVMHSVLLGGEEQRYLLEAAEELALTDGSLVFLPFDTLHYALSPGPEALAAFVNSSQLRRAHDAVLTLTRRCPPGGSVQDSLRRAQEHQELPLDLNLKQVSPLFGTIYDAVFLLAGGVKRARTAVGGGWVSGASVARQVREAQVSGFCGVLGRTEEPSFVLLDTDASGEQLFATHLLDPVLGSLRSAGTPMHFPRGGPAPGPDPSCWFDPDVICNGGVEPGLVFVGFLLVIGMGLTGAFLAHYLRHRLLHMQMASGPNKIILTLEDVTFLHPPGGSSRKVVQGSRSSLATRSASDIRSVPSQPQESTNVGLYEGDWVWLKKFPGEHHMAIRPATKTAFSKLRELRHENVALYLGLFLAGTADSPATPGEGILAVVSEHCARGSLHDLLAQREIKLDWMFKSSLLLDLIKGMRYLHHRGVAHGRLKSRNCVVDGRFVLKVTDHGHGRLLEAQRVLPEPPSAEDQLWTAPELLRDPSLERRGTLAGDVFSLAIIMQEVVCRSTPYAMLELTPEEVIQRVRSPPPLCRPLVSMDQAPMECIQLMTQCWAEHPELRPSMDLTFDLFKSINKGRKTNIIDSMLRMLEQYSSNLEDLIRERTEELEQEKQKTDRLLTQMLPPSVAEALKMGTSVEPEYFEEVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGAHDVYKVETIGDAYMVASGLPQRNGQRHAAEIANMSLDILSAVGSFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVNMSTVRILRALDQGFQMECRGRTELKGKGIEDTYWLVGRLGFNKPIPKPPDLQPGASNHGISLQEIPPERRKKLEKARPGQFTGK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
163	Phosphorylation	PGTRAAGTTAPAVTP CCCCCCCCCCCCCCH	18.30	23140645
164	Phosphorylation	GTRAAGTTAPAVTPA CCCCCCCCCCCCCHH	29.71	23140645
169	Phosphorylation	GTTAPAVTPAADALY CCCCCCCCHHHHHHH	14.87	23140645
176	Phosphorylation	TPAADALYVLLRAFR CHHHHHHHHHHHHHH	7.26	23140645
300	N-linked_Glycosylation	EALAAFVNSSQLRRA HHHHHHHCHHHHHHH	29.50	-
530	Phosphorylation	SRKVVQGSRSSLATR CCCCCCCCHHHCCCC	16.34	22817900
532	Phosphorylation	KVVQGSRSSLATRSA CCCCCCHHHCCCCCH	31.25	22817900
533	Phosphorylation	VVQGSRSSLATRSAS CCCCCHHHCCCCCHH	22.40	22817900
538	Phosphorylation	RSSLATRSASDIRSV HHHCCCCCHHHHCCC	27.98	22817900
558	Phosphorylation	ESTNVGLYEGDWVWL CCCCCCEECCCEEEE	16.37	28576409
810	Phosphorylation	LTFDLFKSINKGRKT CCHHHHHHHCCCCCC	24.86	30387612
852	Phosphorylation	LEQEKQKTDRLLTQM HHHHHHHHHHHHHHH	24.69	25195567
857	Phosphorylation	QKTDRLLTQMLPPSV HHHHHHHHHHCCHHH	19.27	25195567
863	Phosphorylation	LTQMLPPSVAEALKM HHHHCCHHHHHHHHC	31.83	25195567

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
530	S	Phosphorylation	Kinase	GUCY2D	P52785	PSP
532	S	Phosphorylation	Kinase	GUCY2D	P52785	PSP
533	S	Phosphorylation	Kinase	GUCY2D	P52785	PSP
538	S	Phosphorylation	Kinase	GUCY2D	P52785	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GUC2E_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GUC2E_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of GUC2E_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.