SAM50_MOUSE - dbPTM
SAM50_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SAM50_MOUSE
UniProt AC Q8BGH2
Protein Name Sorting and assembly machinery component 50 homolog
Gene Name Samm50
Organism Mus musculus (Mouse).
Sequence Length 469
Subcellular Localization Mitochondrion outer membrane
Multi-pass membrane protein. Cytoplasm . Mitochondrion .
Protein Description Plays a crucial role in the maintenance of the structure of mitochondrial cristae and the proper assembly of the mitochondrial respiratory chain complexes. Required for the assembly of TOMM40 into the TOM complex..
Protein Sequence MGTVHARSLEPLPSSGTDFGALGEEAEFVEVEPEAKQEILENKDVVVQHVHFDGLGRTKDDIIICEIGEVFKAKNLIEVMRRSHEAREKLLRLGIFRQVDVLIDTCHGEDALPNGLDVTFEVTELRRLTGSYNTMVGNNEGSMVLGLKLPNLLGRAEKVTFQFSYGTKETSYGLSFFKPQPGNFERNFSVNLYKVTGQFPWSSLRETDRGVSAEYSFPLWKTSHTVKWEGVWRELGCLSRTASFAVRKESGHSLKSSLSHAMVIDSRNSSILPRRGALFKVNQELAGYTGGDVSFIKEDFELQLNKPLALDSVFSTSLWGGMLVPIGDKPSSIADRFYLGGPTSVRGFSMHSIGPQSEGDYLGGEAYWAGGLHLYTPLPFRPGQGGFGELFRTHFFLNAGNLCNLNYGEGPKAHIRKLAECIRWSYGAGVVLRLGNIARLELNYCIPMGVQGGDRICDGVQFGAGIRFL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MGTVHARSLE
-----CCCEECCCCC		14.0728059163
36UbiquitinationVEVEPEAKQEILENK
EEECHHHHHHHHHCC		46.96-
65S-nitrosocysteineTKDDIIICEIGEVFK
CCCCEEEEECHHHHH		1.88-
65S-palmitoylationTKDDIIICEIGEVFK
CCCCEEEEECHHHHH		1.8828526873
65GlutathionylationTKDDIIICEIGEVFK
CCCCEEEEECHHHHH		1.8824333276
65S-nitrosylationTKDDIIICEIGEVFK
CCCCEEEEECHHHHH		1.8821278135
178UbiquitinationSYGLSFFKPQPGNFE
EEEEEEECCCCCCCC		40.5122790023
237S-nitrosocysteineGVWRELGCLSRTASF
HHHHHHHCEEEEEEE		4.95-
237S-nitrosylationGVWRELGCLSRTASF
HHHHHHHCEEEEEEE		4.9521278135
239PhosphorylationWRELGCLSRTASFAV
HHHHHCEEEEEEEEE		31.49-
243PhosphorylationGCLSRTASFAVRKES
HCEEEEEEEEEEHHH		17.0829176673
248MethylationTASFAVRKESGHSLK
EEEEEEEHHHCCCCC		50.02-
250PhosphorylationSFAVRKESGHSLKSS
EEEEEHHHCCCCCHH		44.8627841257
255MethylationKESGHSLKSSLSHAM
HHHCCCCCHHCCEEE		40.80-
270PhosphorylationVIDSRNSSILPRRGA
EEECCCCCCCCCCCC		31.5219854140
344PhosphorylationFYLGGPTSVRGFSMH
EECCCCCCCCCEECC		16.9824719451
403S-nitrosocysteineFLNAGNLCNLNYGEG
EEECCCCCCCCCCCC		6.71-
403S-nitrosylationFLNAGNLCNLNYGEG
EEECCCCCCCCCCCC		6.7120925432
417MalonylationGPKAHIRKLAECIRW
CCHHHHHHHHHHHHH		51.9926320211
421S-nitrosylationHIRKLAECIRWSYGA
HHHHHHHHHHHHCCC		1.8121278135
421S-nitrosocysteineHIRKLAECIRWSYGA
HHHHHHHHHHHHCCC		1.81-
445S-nitrosylationARLELNYCIPMGVQG
EEEEEEEEEECCCCC		2.4721278135
445S-palmitoylationARLELNYCIPMGVQG
EEEEEEEEEECCCCC		2.4728526873
445S-nitrosocysteineARLELNYCIPMGVQG
EEEEEEEEEECCCCC		2.47-
457S-nitrosocysteineVQGGDRICDGVQFGA
CCCCCCCCCCCCCCC		3.77-
457S-nitrosylationVQGGDRICDGVQFGA
CCCCCCCCCCCCCCC		3.7721278135
457S-palmitoylationVQGGDRICDGVQFGA
CCCCCCCCCCCCCCC		3.7728526873
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SAM50_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SAM50_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SAM50_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
AT5F1_HUMANATP5F1physical
26496610
CAZA2_HUMANCAPZA2physical
26496610
TCPZ_HUMANCCT6Aphysical
26496610
CLK3_HUMANCLK3physical
26496610
CLH1_HUMANCLTCphysical
26496610
DREB_HUMANDBN1physical
26496610
GELS_HUMANGSNphysical
26496610
MYO1B_HUMANMYO1Bphysical
26496610
MYH9_HUMANMYH9physical
26496610
RFA1_HUMANRPA1physical
26496610
S10A4_HUMANS100A4physical
26496610
SPTN1_HUMANSPTAN1physical
26496610
TAF2_HUMANTAF2physical
26496610
TAF6_HUMANTAF6physical
26496610
TCPA_HUMANTCP1physical
26496610
PRDX2_HUMANPRDX2physical
26496610
TPM1_HUMANTPM1physical
26496610
TPM2_HUMANTPM2physical
26496610
TCPG_HUMANCCT3physical
26496610
FXR1_HUMANFXR1physical
26496610
LRRF2_HUMANLRRFIP2physical
26496610
MED17_HUMANMED17physical
26496610
AKA12_HUMANAKAP12physical
26496610
RPP38_HUMANRPP38physical
26496610
TCPH_HUMANCCT7physical
26496610
TCPD_HUMANCCT4physical
26496610
TCPB_HUMANCCT2physical
26496610
EBP_HUMANEBPphysical
26496610
TCPQ_HUMANCCT8physical
26496610
PRDX3_HUMANPRDX3physical
26496610
STIP1_HUMANSTIP1physical
26496610
MIC60_HUMANIMMTphysical
26496610
XPOT_HUMANXPOTphysical
26496610
TCPE_HUMANCCT5physical
26496610
CYTSA_HUMANSPECC1Lphysical
26496610
PRDX5_HUMANPRDX5physical
26496610
RT17_HUMANMRPS17physical
26496610
DGCR8_HUMANDGCR8physical
26496610
MIC19_HUMANCHCHD3physical
26496610
ERBIN_HUMANERBB2IPphysical
26496610
KLHL7_HUMANKLHL7physical
26496610
KLH12_HUMANKLHL12physical
26496610
TFB2M_HUMANTFB2Mphysical
26496610
DCAKD_HUMANDCAKDphysical
26496610
FXRD2_HUMANFOXRED2physical
26496610
ARP5L_HUMANARPC5Lphysical
26496610
FA58A_HUMANFAM58Aphysical
26496610
OSBL5_HUMANOSBPL5physical
26496610
ZCH18_HUMANZC3H18physical
26496610
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SAM50_MOUSE

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Related Literatures of Post-Translational Modification

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